Mikroplasty a nanomateriály: Porozumění nově se objevujícím kontaminantům v environmentální analýze

Kyselina hyaluronová a&nbsp;sfingolipidy – dvě látky, které mají klíčový význam pro zdraví a&nbsp;funkci pokožky. Právě jejich propojení stálo v&nbsp;centru bádání Martina Juhaščika, absolventa FaF UK, který za svou disertační práci získal Mimořádnou cenu rektorky a&nbsp;také Zvláštní uznání poroty v&nbsp;soutěži Cena Sanofi za farmacii. Ocenění mu předal nositel Nobelovy ceny za chemii Jean-Marie Lehn.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_2_4b1562263b.jpg" alt="Forum: magazín Univerzity Karlovy/Michal Novotný: Společná cesta k patentu: Jak UK a Contipro tvoří inovace " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_2_4b1562263b.jpg 234w," sizes="100vw" width="1400" height="933">„Chtěli jsme vytvořit systém, který by dokázal efektivně dopravit účinné látky do pokožky, a&nbsp;přitom byl stabilní a&nbsp;šetrný. Kyselina hyaluronová je přirozeně hydratující a&nbsp;biokompatibilní (nevyvolává v&nbsp;těle nežádoucí reakce – pozn. red.), sfingolipidy zase posilují kožní bariéru. Spojením jejich vlastností vzniká kombinace s&nbsp;velkým aplikačním potenciálem,“ vysvětluje Martin Juhaščik.<h5>Začátky na kuchyňském robotu</h5>Na svém projektu pracoval v&nbsp;biotechnologické společnosti Contipro, s&nbsp;níž má Farmaceutická fakulta UK dlouhodobé vazby. Dnes zde působí jako vědecký pracovník. Firmu, která dnes patří mezi světovou špičku v&nbsp;oblasti výroby a&nbsp;zpracování kyseliny hyaluronové, založil v&nbsp;roce 1990 docent Vladimír Velebný, který se tehdy zabýval výzkumem pojivových tkání. Rozhodl se převést své poznatky z&nbsp;akademického prostředí do praxe a&nbsp;založil malé výrobní družstvo. Cesta za vysněnou výrobou kyseliny hyaluronové začala mícháním výživových doplňků pro sportovce na kuchyňském robotu určeném pro školní jídelny.Ze skromných začátků se firma rozrostla v&nbsp;moderní biotechnologické centrum se sídlem v&nbsp;Dolní Dobrouči, asi šedesát kilometrů od Hradce Králové ve směru na Orlické hory. Martin Juhaščik bydlí s&nbsp;manželkou kousek od ní. „Do práce většinou jezdím na kole. A&nbsp;nejsem sám. Celý region je protkán cyklostezkami, a&nbsp;když v&nbsp;zimě napadne sníh, pár kolegů přijíždí na běžkách. Je tu příjemná, přátelská atmosféra,“ popisuje.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_5_ba92fa8f8d.jpg" alt="Forum: magazín Univerzity Karlovy/Michal Novotný: Společná cesta k patentu: Jak UK a Contipro tvoří inovace " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_5_ba92fa8f8d.jpg 234w," sizes="100vw" width="1200" height="800"><h5>Když technologie nestačí, vyvineme si vlastní</h5>Ve firmě Contipro dnes vzniká široké spektrum produktů – od kyseliny hyaluronové v&nbsp;různé kvalitě a&nbsp;čistotě až po inovativní aplikační formy jako jsou tenké filmy, mikrovlákna a&nbsp;nanovlákna. Hned na počátku ale musela společnost čelit výzvě, protože vhodné technologie, které by umožňovaly vyrobit kyselinu hyaluronovou podle jejích potřeb, nebyly dostupné. Z&nbsp;této situace se zrodila vize, která dnes patří k&nbsp;jejím největším přednostem. Všechny klíčové technologie si Contipro vyvíjí samo. Firma má vlastní divizi, která navrhuje a&nbsp;vyrábí specializované přístroje, včetně linky na výrobu nanovláken ve velkém měřítku. „Díky tomu dokážeme všechny procesy dělat přímo u&nbsp;nás. Od produkce kyseliny hyaluronové až po její finální úpravu,“ vysvětluje Martin Juhaščik.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_6_98b4b12f4c.jpg" alt="Forum: magazín Univerzity Karlovy/Michal Novotný: Společná cesta k patentu: Jak UK a Contipro tvoří inovace " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_6_98b4b12f4c.jpg 235w," sizes="100vw" width="1200" height="799">Tuto tělu vlastní sloučeninu zajišťující hydrataci a&nbsp;pružnost tkání firma vyrábí biotechnologickou cestou, konkrétně fermentací. Jde o&nbsp;čistý a&nbsp;ekologický proces bez škodlivých odpadů. Výsledný produkt se pak dělí podle čistoty a&nbsp;použití – od kosmetické kvality pro pleťové krémy, přes potravinářskou pro doplňky stravy, až po farmaceutickou třeba pro oční kapky nebo injekční roztoky. Kromě vlastních produktů však firma dodává kyselinu hyaluronovou také farmaceutickým a&nbsp;kosmetickým společnostem po celém světě, a&nbsp;patří mezi pět největších světových producentů, kteří ji dokážou vyrábět v&nbsp;nejvyšší kvalitě. Firemní know-how chrání téměř sto třicet patentů. O&nbsp;jeden z&nbsp;nich se zasloužil díky svému doktorandskému výzkumu i&nbsp;Martin Juhaščik. Nyní se v&nbsp;Contipru zaměřuje na zkoumání vlivu samotné kyseliny hyaluronové na pokožku a&nbsp;sám také pomáhá vést nové studenty, kteří se vydávají podobnou cestou jako před pár lety on.<h5>Z&nbsp;mladých talentů vědci a&nbsp;vědkyně</h5>Důvodem, proč se firmě daří přitahovat špičkové výzkumníky do malé obce pod Orlickými horami, je podle Juhaščika promyšlený systém vzdělávání a&nbsp;podpory mladých talentů. Contipro působí v&nbsp;regionu už více než třicet let a&nbsp;během této doby zde vybudovalo vedle špičkových laboratoří i&nbsp;vlastní vzdělávací programy. Spolupracuje se středními školami a&nbsp;nabízí bakalářské i&nbsp;diplomové práce pro studenty vysokých škol. Mnoho zaměstnanců firmy pochází přímo z&nbsp;regionu, což vytváří silné komunitní prostředí. Mladí lidé tu začínají jako stážisté, postupně si zkoušejí různé pozice a&nbsp;často ve firmě zůstávají natrvalo. Contipro nabízí i&nbsp;takzvané Trainee programy pro absolventy, díky nimž mohou poznat různé části výzkumu a&nbsp;výroby a&nbsp;najít oblast, která jim nejvíc vyhovuje.„I já jsem původně přišel do Contipra v&nbsp;rámci disertační práce ve spolupráci s&nbsp;Farmaceutickou fakultou UK,“ vzpomíná Juhaščik. „Byla to skvělá příležitost propojit akademický výzkum s&nbsp;praxí – a&nbsp;vidět, jak se vědecký nápad může proměnit v&nbsp;hmatatelný výsledek,“ shrnuje vědec.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_4_e34a203649.jpg" alt="Forum: magazín Univerzity Karlovy/Michal Novotný: Společná cesta k patentu: Jak UK a Contipro tvoří inovace " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Forum_magazin_Univerzity_Karlovy_Michal_Novotny_Spolecna_cesta_k_patentu_Jak_UK_a_Contipro_tvori_inovace_4_e34a203649.jpg 234w," sizes="100vw" width="1200" height="800"><blockquote><h5>PharmDr. Martin Juhaščik, Ph.D.</h5>Absolvent Farmaceutické fakulty Univerzity Karlovy, kde vystudoval farmaceutickou technologii. Ve své disertační práci se zaměřil na konjugáty kyseliny hyaluronové se sfingolipidy určené pro topické použití, za kterou získal Mimořádnou cenu rektorky UK a Zvláštní uznání poroty v soutěži Cena Sanofi za farmacii. Dnes působí jako vědecký pracovník ve společnosti Contipro v Dolní Dobrouči, kde se věnuje vývoji biomateriálů a kosmetických surovin na bázi kyseliny hyaluronové. Je také spoluautorem českého patentu v této oblasti a podílí se na vedení mladých výzkumníků, kteří ve firmě získávají své první vědecké zkušenosti.</blockquote>

 Společná cesta k patentu: Jak UK a Contipro tvoří inovace 

<div><div>Náš imunitní systém je neuvěřitelně silný. Dokáže totiž mimo jiné sám rozpoznat a zničit rakovinné buňky. Nádorové buňky jsou ale na tento útok připravené: vytvářejí si vlastní „neviditelné štíty“, které je před imunitním systémem chrání.</div></div><div>Průlom v léčbě rakoviny přinesly látky, které dokážou imunitní buňky znovu aktivovat. Ty pak mohou proniknout neviditelným štítem nádoru a znovu proti němu zasáhnout. Bohužel je ale tato léčba účinná zatím jen u 20–50 % pacientů. Vědci a vědkyně proto hledají nové způsoby, jak imunitní buňky znovu aktivovat. Důležitou roli v tomto procesu hraje malá a dobře známá molekula zvaná adenosin.Když jsou nádorové buňky ve stresu nebo odumírají, uvolňují do svého okolí molekuly adenosintrifosfátu (ATP). Tím dávají imunitnímu systému najevo, že něco není v pořádku. Mikroprostředí nádoru však zároveň skrývá právě onen neviditelný štít, který uvolněné ATP rychle rozkládá na adenosin, a varovný signál tak zaniká. K této přeměně slouží dva enzymy označované CD39 a CD73.Uvolněný adenosin pak působí jako uklidňující chemický signál: váže se na imunitní buňky, zpomaluje je a snižuje jejich schopnost rozpoznávat a ničit rakovinné buňky. Pokud by se podařilo zablokovat enzym CD73, bylo by možné neviditelný štít nádoru vyřadit z provozu a otevřít tak novou cestu k léčbě rakoviny.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="ÚOCHB: Nové látky mohou podpořit imunitní systém v boji s rakovinou" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363">Mezioborové týmy z ÚOCHB vedené Janem Řezáčem, Janem Konvalinkou a Michalem Hockem využily novou metodu vysokokapacitního screeningu a otestovaly více než 5000 sloučenin. Díky tomu objevily dva deriváty ribonukleosidů, které se ukázaly jako slibné inhibitory enzymu CD73.Vědci pak jejich účinnost dál zvýšili úpravami základní chemické struktury, zejména přidáním prostorově objemných (hetero)arylových skupin. Následná optimalizace navíc zlepšila i jejich farmakokinetické vlastnosti, tedy jak se léčivá látka v organismu vstřebává, distribuuje, metabolizuje a vylučuje. Výsledkem jsou sloučeniny, které vydrží v organismu dostatečně dlouhou dobu, zároveň mají vysokou rozpustnost a také selektivitu vůči příbuzným enzymům, například právě CD39.Buněčné experimenty ukázaly, že tyto látky snižují produkci adenosinu v rakovinných buňkách, obnovují aktivaci imunitních T buněk a zároveň nepůsobí toxicky na lidské tkáňové buňky. Nejúčinnější ze zkoumaných látek dosáhla inhibiční konstanty v řádu jednotek pikomolů. Jedná se o hodnotu, která vyjadřuje, jak silně se inhibitor váže na cílový enzym nebo receptor a jak účinně ho blokuje. Čím nižší je tato hodnota, tím silněji a účinněji inhibitor na svůj cíl působí.Publikované výsledky představují důležitý výchozí bod pro navazující výzkum a další rozvoj této slibné třídy látek. Budoucí studie in vivo i kombinované experimenty nyní pomohou podrobněji prověřit účinnost těchto látek a ukázat, do jaké míry by mohly najít uplatnění v léčbě nádorových onemocnění.<blockquote><h4>Původní článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">Silné kompetitivní inhibitory ekto-5′-nukleotidázy (CD73) na bázi 6-(het)aryl-7-deazapurinových ribonukleosidových 5′-O-bisfosfonátů</a></h4>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal HocekACS Pharmacol. Transl. Sci. 2026, 9, 1, 191–213<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstrakt</h4>CD73 produkuje v mikroprostředí nádoru imunosupresivní adenosin a představuje slibný cíl pro imunoterapii nádorových onemocnění. Navrhli jsme a systematicky studovali rozmanité 2-substituované 7-deazapurinové ribonukleosidové 5′-O-bisfosfonáty nesoucí různé (het)arylové skupiny v poloze 6 a prokázali jsme jejich vysoce účinnou a selektivní inhibiční aktivitu vůči CD73. Nejaktivnější sloučeniny (s Ki v řádu jednotek pikomolů) obsahovaly v poloze 6 bicyklické (het)arylové skupiny v kombinaci s chlorem v poloze 2. Další optimalizace farmakokinetických vlastností vedla k identifikaci inhibitorů s nízkou clearance, dlouhým poločasem, vysokou rozpustností a vynikající selektivitou vůči CD39 a NTPDase3. Tyto sloučeniny účinně potlačovaly tvorbu adenosinu v buňkách MDA-MB-231, obnovovaly aktivaci CD8+ T lymfocytů a byly netoxické vůči lidským fibroblastům. Celkově se jejich profil příznivě srovnává s AB680, inhibitorem CD73, který je v současnosti ve fázi I/II klinických studií.</div>

Nové látky mohou podpořit imunitní systém v boji s rakovinou

Životní prostředí

Vědecký článek

Popularizace

Věda a výzkum

Článek

ÚOCHB AV ČR je přední mezinárodně uznávaná vědecká instituce, jejímž hlavním posláním je základní výzkum v oblasti chemické biologie a medicinální chemie, organické a materiálové chemie, chemie přírodních látek, biochemie a molekulární biologie, fyzikální chemie, teoretické chemie a analytické chemie.

Ústav organické chemie a biochemie AV ČR

Společnost Organomation, založená v roce 1959, navrhuje a vyrábí vysoce kvalitní dusíkové koncentrátory a extrakční systémy. Jejich laboratorní přístroje, známé svou inovativností a odolností, se používají po celém světě pro efektivní přípravu vzorků a jsou doprovázeny silnou zákaznickou podporou.

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Reportáže, rozhovory, zprávy o vědeckých projektech a studentských akcích ... Jsme online informační bránou Univerzity Karlovy.

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<h3>Solving Problems That Matter - a Waters webinar series featuring USP speakers</h3>
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Analyzing over-the-counter formulations can be overwhelming due to the wide range of APIs and excipients used in varying concentrations. These excipients can cause problematic matrix effects and coelutions, making the analysis of formulations complex. Our panelists will discuss how to leverage aQbD software to develop a single chromatographic method suitable to analyze multiple APIs in a variety of formulations.
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Dr. Fadi Alkhateeb is a Senior Scientist in the Scientific Operations Department at WatersCorporation HQ in Milford, MA USA. He joined Waters in 2017 and since then he has beenmainly focusing on exploring various approaches for analytical method development forpharmaceutical drugs. Prior to joining Waters, he was a postdoctoral fellow at the University ofCalgary (Calgary, AB, Canada), where he did research at Alberta Sulphur Research, one ofNorth America&#39;s leading Sulphur research institutes. He received his PhD from the University ofCalgary, focusing on the development of novel, rapid separation and sample preparationtechniques for the analysis of a wide range of chemical compounds. Dr. Alkhateeb publishedseveral peer-reviewed articles in top analytical journals.​
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Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With over 20 years of experience in providing chromatography and mass spectrometry solutions, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France.
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Waters Corporation: Solving Problems That Matter - a Waters webinar series featuring USP speakers

aQbD for OTC products

Solving Problems That Matter - a Waters webinar series featuring USP speakers. Episode 4: aQbD for OTC products.

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<h5>10:00 a.m. PT/ 1:00 p.m. ET - Excel strategies for mass spectrometry data analysis</h5>
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June 7th at 11:00 AM : RI &amp; dn/dc
<ul>
<li>A perfect match: MALS and RI</li>
<li>The importance of dn/dc and how to determine it</li>
</ul>
June 21st at 11:00 AM : DLS 
<ul>
<li>Benefits of measuring the Hydrodynamic Radius (Rh)</li>
<li>Dynamic Light Scattering in cuvette, high throughput and online</li>
</ul>
July 5th at 11:00 AM : Dynamics data processing tips &amp; tricks
<ul>
<li>Data interpretation and data filter</li>
<li>Use your Dyna Pro instrument to get: colloidal stability (kD/A2), thermal stability, viscosity or particle concentration</li>
</ul>
<blockquote>
Presenter: Dr. Christian Ackerschott
</blockquote>
<blockquote>
Dr. Christian Ackerschott studied Chemistry at the University of Cologne and finished with his diploma thesis in Biochemistry. He completed his studies with the PhD thesis “Characterization of Recombinant Flagelliform Spider Silk Proteins” at the Technische Universität München, where AF4-MALS was used as an essential characterization method.
</blockquote>
<blockquote>
Since 2007, Christian works at Wyatt Technology as Application Scientist and is now Head of Customer Service. His tasks also include customer trainings in Dernbach and onsite as well as education and training of the local Field Application Scientists.
</blockquote>

Waters Corporation: EU Live Interactive Web Series

SEC-MALS

SEC-MALS - Applications and data interpretation. Data analysis in ASTRA.

Listeria monocytogenes, a foodborne pathogen, poses a particular risk to vulnerable populations such as infants, the elderly, immunocompromised individuals, and pregnant women. Timely and accurate identification helps to prevent outbreaks of listeriosis and is essential for ensuring food safety and protection of public health.
In this webinar, Dr. Helene Oberreuter, food microbiologist and senior government councilor, will highlight a validated workflow for the differentiation of Listeria monocytogenes serogroups by FT-IR spectroscopy. The workflow consists of species identification by MALDI-TOF mass spectrometry (MALDI Biotyper®) followed by serogroup differentiation with the IR Biotyper® using a classifier which is based on an artificial neural network.
Key learning objectives
<ul>
<li>Explore the use of FT-IR spectroscopy in food pathogen detection
</li>
<li>Discover a validated workflow for serogroup differentiation
</li>
<li>Learn how to apply an artificial neural network to pathogen classification
</li>
<li>Gain insights into the preselection of samples by FT-IR for whole genome sequencing
</li>
</ul>
<blockquote>
Presenter: Dr. Helene Oberreuter (Food Microbiologist and Senior Government Councilor, CVUA Stuttgart, Germany)
</blockquote>
<blockquote>
Presenter: Lawrence Howes (SelectScience)
</blockquote>
Who should attend?
Those working in food microbiology laboratories, reference laboratories and centers for food pathogens, state and public health laboratories, and centers for disease control and prevention
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Bruker - Validated differentiation of Listeria monocytogenes by FT-IR spectroscopy using an artificial neural network based classifier

Validated differentiation of Listeria monocytogenes by FT-IR spectroscopy using an artificial neural network based classifier

Validated workflow for the differentiation of Listeria monocytogenes serogroups by FT-IR spectroscopy.

Differentiation of Listeria monocytogenes-FT-IR spectroscopy

In this training session, the METTLER TOLEDO product managers will address the questions that are most commonly asked in the field. They will talk about weight handling, maintenance of mass comparators, selection of products, elevation dependence of measurements, and many more topics. Additionally, you will have the opportunity to ask your own questions in an open Q&amp;A session at the end.
Key Takeaways
This is a great opportunity for all mass metrologists, as those questions that many others ask might also be of relevance to you. 
Program
<ul>
<li>Discover answers to the most frequently asked questions in mass metrology
</li>
<li>Learn more about weight handling, mass comparator maintenance, etc.
</li>
<li>Ask our experts your own questions
</li>
</ul>
<blockquote>
Speaker: Dr. Frederik Eiler (METTLER TOLEDO, Product Manager Metrology Solutions)
</blockquote>
<blockquote>
Speaker: Mark Kliebenschädel (METTLER TOLEDO, Product Manager Metrology Solutions)
</blockquote>

Mettler-Toledo: Mass Calibration – Most Frequently Asked Questions

Mass Calibration – Most Frequently Asked Questions

Opportunity for all mass metrologists, as those questions that many others ask might also be of relevance to you.

Laboratories are constantly trying to manage their efficiency. When it comes to ion chromatography, increasing the speed of the analysis is often the first thing that comes to mind to achieve this goal. But what are the tradeoffs?
In this webinar, we’ll take a dive into the influencing factors for chromatographic separation, what levers you have when trying to speed analysis up, what you gain and what you might give up for the compressed run time. We’ll try to help you decide where to draw the line for your lab while sharing some method examples that benefit from fast run times. Lastly, we’ll look at other strategies for efficiency like automated sample prep. 
Key Learning Points:
<ul>
<li>Learn about speeding up IC methods, including factors influencing chromatographic separation</li>
<li>Understand the trade-offs and things to consider when speeding up your analysis</li>
<li>Learn about alternatives to increase sample throughput when the tradeoff for speed is too much</li>
</ul>
Who Should Attend?
<ul>
<li>People developing IC methods </li>
<li>Anyone using ion chromatography</li>
<li>Lab managers and directors interested in strategies for faster lab results</li>
<li>Students and researchers looking to expand their fundamental understanding of IC</li>
</ul>
<blockquote>
Presenter: Bikash Chouhan, PhD (Applications Specialist, Ion Chromatography, Metrohm USA)
</blockquote>
<blockquote>
Bikash Chouhan is an Applications Specialist for Ion Chromatography at Metrohm USA. He completed his PhD in Analytical Chemistry from the University of Texas at Arlington (UTA). His area of research during his PhD was in Capillary Scale Ion Chromatography. He has worked as a Post Doc at Department of Chemistry and Biochemistry, UTA and as a Senior Scientist in IC at Eurofins, before joining Metrohm USA. He is currently involved in expanding IC applications to more unique and challenging sample matrices.
</blockquote>
<blockquote>
presenter: Linx Waclaski (Product Manager Ion Chromatography, Metrohm USA)
</blockquote>
<blockquote>
Linx Waclaski is the Product Manager for Ion Chromatography at Metrohm USA in Riverview, Florida. He has years of experience in multiple chromatographic techniques, including ion chromatography, gas chromatography, liquid chromatography, and mass spectrometry, with extensive experience in R&amp;D and applications development. His chromatography applications experience extends across environmental, food safety, and life sciences industries. He has an M.S. in Forensic Science from Duquesne University.
</blockquote>

Metrohm: Speeding up Your IC: Is Faster Always Better?

Speeding up Your IC: Is Faster Always Better?

Influencing factors for chromatographic separation, levers to speed analysis up, gains and losses of the compressed run time.

Per- and poly-fluorinated substances (PFAS) are synthetic organic compounds widely used in products and processes because of their hydrophobic and non-stick properties. Known as ‘forever chemicals’ due to their persistence in the environment, PFAS are identified as a class of environmental contaminants of high concern. Increasingly, environmental and regulatory agencies are taking action to address PFAS contamination, setting sub-parts-per-billion (ppb) tolerance thresholds to limit exposure and protect public health.
While targeted techniques can detect these compounds at low levels, the number of current targets is limited. Consequently, the use of non-targeted High Resolution Mass Spectrometry (HRMS) is becoming important for the analysis of PFAS. This is due to the rapid rate of detection of novel PFAS in samples and a lack of analytical standards.
Join us for these short two-part series (30 min) to take your PFAS analysis to the next level, where we will demonstrate the benefit of using HRMS workflows for advanced discovery, identification and quantitation of PFAS. 
Learn about recent LC developments and how the Xevo™ G3 QTof, and a SELECT SERIES™ Cyclic™ Ion Mobility Spectrometry (IMS) rise to this analytical challenge. 
Gain practical insights on workflows used by our scientists for your own PFAS investigations; see the range of inlet options available, how to run samples, experience the latest software for data acquisition and interpretation.
Register for:
Part 1 – 16th May (10:30-11:00 BST | 11:30-12:00 CEST)
LC developments and using Xevo G3 QTof for quantitation and screening of PFAS 
Part 2 – 23rd May (10:30- 11:00 BST | 11:30-12:00 CEST)
Advanced non-target approaches using Ion mobility
Key learning topics:
<ul>
<li>Recent developments in LC and why selection of column chemistries is critical for PFAS analysis </li>
<li>Learn about HRMS and IMS in the quest to discover new PFAS compounds and enhance confidence in identification of PFAS </li>
<li>See our chemists in action in the lab and gain practical insights on workflows</li>
</ul>
Who should attend?
<ul>
<li>Researchers and scientists actively addressing the PFAS issue using Liquid Chromatography or Mass Spectrometry.</li>
<li>PFAS Program Managers</li>
<li>Laboratory Managers</li>
</ul>
<blockquote>
Presenter: Stuart Adams (Consulting Scientist, Testing &amp; Lab Services, Food and Environmental, Waters Corporation)
</blockquote>
<blockquote>
Stuart started his career by attending the University of Glasgow studying for an honours degree in Food and Environmental Chemistry where his passion for solving analytical challenges started. He furthered his education with a doctorate from the University of Leeds in analytical chemist. Subsequently he spent 17 years working at Fera on a variety of projects looking at the detection of chemicals in challenging food and environmental samples using a variety of detection techniques. Whilst at Fera he has represented the UK at several European Union Reference Laboratory meetings for pesticide analysis and is a recognised international expert in his field. Stuart joined Waters Corporation in 2018 and currently works as a Consulting Scientist where he still loves to work on solving the analytical challenges that matter.
</blockquote>
<blockquote>
Presenter: Dr. Hania Khoury-Hollins (Principal Scientist, Waters Corporation)
</blockquote>
<blockquote>
Hania Khoury-Hollins is a scientist and researcher at Waters Corporation. She holds a bachelor’s degree in science, which laid the foundation for her scientific pursuits. In 2001, Hania earned her master’s degree in Toxicology, deepening her understanding of the impact of chemicals on living organisms. In 2005 she successfully defended her Ph.D. in physical chemistry from University René Descartes - Paris V (France). After undertaking several different projects in academia Hania spent some time working at Agilent before joining Waters.
</blockquote>
<blockquote>
At Waters, her work revolves around developing cutting-edge analytical techniques and their applications with a focus on Liquid Chromatography Coupled with High-Resolution Mass Spectrometry (LC-HRMS). Her expertise encompasses a diverse range of applications, including drug development, proteomics, metabolomics, and lipidomics. More recently, Hania has been developing applications strategies for per- and polyfluoroalkyl substances (PFAS).
</blockquote>

Waters Corporation: Take your PFAS Analysis to the Next Level (1) with Advanced MS for Non-Targeted Analysis

LC developments and using Xevo G3 QTof for quantitation and screening of PFAS

Learn about HRMS and IMS in the quest to discover new PFAS compounds and enhance confidence in identification of PFAS.

LC developments and using Xevo G3 QTof for PFAS

Whether the goal is to obtain enough intermediate for the next step in a synthetic scheme or to polish a final product, preparative liquid chromatography is one of the primary techniques for isolation compounds from complex mixtures. Despite this fact, purification often seems difficult with many opportunities for undesirable outcomes, such as poor compound purity, low yield, or target loss. All these unfortunate results require time-consuming rework, a detriment to the all-to-familiar compressed timelines evident in so many workplaces today.
The uncertainty and fear associated with scaling up a separation can be mitigated by adopting simple suggestions which help to ensure success. Practical and easily implemented tips for predictable scaleup and successful compound isolation will be the focus of this webinar.
<h5>Key Learning Objectives:</h5>
<ul>
<li>Learn to scale your analytical – prep methods predictably.</li>
<li>Gain knowledge from practical guidance shared for first-time purification success when scaling your LC separation.</li>
<li>Discover how following the rules of scaling PREP LC simplifies the process</li>
<li>Learn how to better control LC scale-up outcomes and boost both target purity and recovery.</li>
</ul>
<blockquote>
Presenter: Jo-Ann Jablonski (Principal Scientist, Waters Corporation)
</blockquote>
<blockquote>
Jo-Ann Jablonski is a Principal Scientist in the Consumables and Lab Automation Group at Waters Corporation. Prior to joining Waters, she worked in biotechnology synthesizing, characterizing, and purifying biomolecules for research and development. She later transitioned to developing a process for the manufacture of a therapeutic peptide product. Since joining Waters, Jo-Ann has provided technical support, training, and application assistance to customers using Waters’ chemistry products and instrumentation, with an emphasis on purification technologies.
</blockquote>

Waters Corporation: Tips for Getting to Predictable Scaleup in Prep LC

Tips for Getting to Predictable Scaleup in Prep LC

Practical and easily implemented tips for predictable scaleup and successful compound isolation.

<h4>LC-MS/MS fundamentals webinar series 2.0</h4>
Advanced techniques for data acquisition and processing
Elevate your analytical expertise with advanced techniques and workflows
Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.
Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.
<h4>This webinar:</h4>
May 21, 2024 11:00 a.m. - 11:30 a.m. CET - Advanced MS/MS method building 
Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.
<h4>Other webinars from the series:</h4>
May 7, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3820">Beyond the fundamentals</a>
June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853">Mastering chromatography</a>
Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.
June 18, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3854">It&#39;s a TRAP! Getting the most out of your QTRAP system</a>
Learn when to utilize QTRAP functionality to create more selective and sensitive methods. July 2, 2024
11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3855">Troubleshooting at the source</a>
Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.
July 16, 2024 11:00 a.m. - 11:30 a.m. CET <a href="https://lcms.labrulez.com/webinar/3856">Automating data processing</a>
Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.
July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3857">Excel strategies for mass spectrometry data analysis</a>
Take an in-depth look at when and how to use Excel to increase your productivity.

SCIEX: LC-MS/MS fundamentals webinar series 2.0

Advanced MS/MS method building

Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series.

The new Thermo Scientific Orbitrap Astral mass spectrometer is setting a new standard for mass spectrometry performance, redefining what is possible and unlocking additional insights into biology and disease mechanisms.
The ability to conduct large cohort protein analysis with faster throughput, deeper coverage, higher sensitivity and accurate and precise quantitation enables a better understanding of the dynamic, temporal and spatial complexities of biology.
In this interactive webinar, we will briefly introduce underlying technology of the Orbitrap Astral mass spectrometry platform before opening the floor to a group of renowned cancer researchers who will describe their own early experiences with the system and their hopes and ambitions for advancing their own researches in this important and rapidly-advancing field.
As a participants in this webinar, you will have the opportunity to engage in an interactive panel discussion with these key opinion leaders and ask questions to further enhance your understanding of the current and future state of mass spectrometry-driven proteome analysis of cancer samples and how that can identify differentially expressed proteins, protein-protein interactions and post-translational modifications that may be associated with cancer development, progression, or response to treatment.
What you will learn:
<ul>
<li>View the latest research in protein profiling</li>
<li>Learn about the Orbitrap mass spectrometry solutions</li>
<li>Discover how your cancer research can be empowered</li>
</ul>
Who should attend?
<ul>
<li>Scientific researchers in the field of cancer proteomics</li>
<li>Mass spectrometrists working in core labs in cancer institutes</li>
<li>Laboratory managers in cancer institutes</li>
</ul>
If you have questions for our experts, please submit them during registrations or send them anytime in advance via email to analyze.eu@thermofisher.com
Live questions will be handled during the webinar in our Q&amp;A chat. 
Short notice: Can&#39;t attend the live broadcast? No problem! Register anyway and you will automatically receive the link to the webinar recording.
<blockquote>
Presenter: Dr. Christian Hock (Senior Manager Instrument Development, Thermo Fisher Scientific)
</blockquote>
<blockquote>
The Orbitrap Astral development team is led by Dr. Christian Hock, who joined the Research team of Dr. Alexander Makarov as Lead Scientist in early 2013. With a strong passion for science and an innate curiosity, Dr. Hock has been involved in all aspects of Astral technology development, from its initial stages of basic research to its successful transition into serial production.
</blockquote>
<blockquote>
In 2017, Dr. Hock transferred to the Bremen R&amp;D organization, where he took the initiative to establish a dedicated R&amp;D team which has been instrumental in bringing the Orbitrap Astral product to fruition. His overarching goal is to exceed customer expectations by delivering cutting-edge products that enable researchers worldwide to accelerate their scientific output. Through his leadership and expertise, he continuously pushes the boundaries of science &amp; technology and strives for excellence in every stage of product development.
</blockquote>
<blockquote>
Presenter: Prof. Michiel Vermeulen (Senior Group Leader, Netherlands Cancer Institure NKI)
</blockquote>
<blockquote>
Presenter: Dr. Harmjan Vos (Head of the Proteomics Facility, University Medical Centre Utrecht)
</blockquote>
<blockquote>
Started his proteomics career as a postdoc in a project of Jeroen Krijgsveld in the lab of Albert Heck at the UU. Then he moved to the lab of Boudewijn Burgering at the Center for Molecular Medicine (CMM) at the UMC Utrecht, trying to understand the intricate connections between cellular signaling pathways and metabolic processes. Since 2014 he is heading the Proteomics facility at CMM, which is involved in the research infrastructure of the Oncode Institute, with an emphasis on single cell proteomics.
</blockquote>
<blockquote>
Presenter: Prof. Jyoti Choudhary (Group Leader, The Institute of Cancer Research)
</blockquote>
<blockquote>
Professor Jyoti Choudhary&#39;s research focuses on the development and implementation of novel mass spectrometry and data analysis approaches for proteome discovery. She is Head of the Proteomics Core Facility and Career Faculty Leader of the Functional Proteomics Research Group.
</blockquote>
<blockquote>
Presenter: Dr. Joanna Kirkpatrick (Technical Sales Specialist, Proteomics, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Jo has a degree in Chemistry from the University of York and a PhD in analytical chemistry from the University of Reading. Following a post-doc in mass spectrometry in the Chemistry department at Oxford, and working as an application scientist at Waters, she has worked in and ran Proteomics Core Facilities in the UK and Germany, including the EMBL in Heidelberg, the Leibniz Institute on Aging in Jena, The Francis Crick Institute in London and CRUK Cambridge.
</blockquote>
<blockquote>
After many years as an experienced Thermo customer, Jo joined the company last year as a Technical Sales Specialist, supporting the whole of the UK/Ireland, Benelux and Nordic regions, in all things proteomics.
</blockquote>
<blockquote>
When she&#39;s not talking about proteomics and mass spectrometry, Jo enjoys ceroc dancing, tennis, scuba diving, travelling, and spending time with her cats, who like to join in on Teams meetings whenever she works from home.
</blockquote>

ThermoFisher Scientific: High throughput protein profiling for cancer research by Orbitrap Astral MS