<p><strong>Třetí ročník pracovního setkání odborníků na vodní ekosystémy pomalu získává na významu. Jedná se o mezioborové setkání, jehož cílem je spojovat informace, projekty a odborníky na vybraná témata ochrany vod.</strong></p><p>Setkání proběhne ve dnech 5. až 6. 2. 2026 v&nbsp;prostorách UJEP, budova CTPO, Pasteurova 15, Ústí nad Labem.</p><blockquote><p><strong>Další informace včetně přednášek z předchozích dvou ročníků konference k dispozici na </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/297"><strong>profilu SeBiChem</strong></a><strong>.</strong></p></blockquote><h3><strong>Program</strong></h3><h4><strong>Čtvrtek 5. února</strong></h4><h5><strong>10:00 – 12:00 Registrace, ubytování – CPTO přízemí</strong></h5><h5><strong>12:00 – 13:00 </strong>Oběd</h5><h5><strong>13:00 – 14:00 Znečištění systému voda/půda ve vztahu k organismům, které v(z) nich žijí</strong></h5><ul><li>Roman Grabic a kol., FROV JČU</li></ul><h5><strong>14:00 – 14:30 Following the Mixtures of Organic Micropollutants with In Vitro Bioassays in Labe/Elbe from Source to Sea</strong></h5><ul><li>Elena Hommel et all, Helmholtz Centre for Environmental Research</li></ul><h5><strong>14:30 – 14:50 Mechorosty na toxických výsypkách v oblasti Sokolova: předběžné výsledky</strong></h5><ul><li>Lucie Fatková a kol., Ústav pro životní prostředí PřFUK</li></ul><h5><strong>14:50 – 15:00 Krátké komerční sdělení</strong></h5><ul><li>František Laštovička, AMEDIS, s.r.o.</li></ul><h5><strong>15:00 – 15:10 Krátké komerční sdělení</strong></h5><ul><li>Petr Barath, Metrohm Česká Republika, s.r.o.</li></ul><h5><strong>15:10 – 15:20 Krátké komerční sdělení</strong></h5><ul><li>Aneta Rychtr, DonauLab</li></ul><h5><strong>15:20 – 15:30 Krátké komerční sdělení</strong></h5><ul><li>J. Kokšal, Shimadzu Handels GmbH-organizační složka</li></ul><h5><strong>15:30 – 16:00 </strong>Přestávka</h5><h5><strong>16:00 – 16:30 Detekce benzenu ve vzorcích z Hustopečí s využitím bioreportéru Pseudomonas putida TVA8</strong></h5><ul><li>Josef Trögl, FŽP UJEP</li></ul><h5><strong>16:30 – 16:50 Vlivy působící na vodní bezobratlé v malých zemědělských tocích</strong></h5><ul><li>&nbsp;Libuše Barešová a kol., ČHMI</li></ul><h5><strong>16:50 – 17:10 &nbsp;Diclofenac jako nebezpečná látka kontaminující životní prostředí: výskyt, toxicita a možnosti dekontaminace</strong></h5><ul><li>Marian Rucki, Státní zdravotní ústav:</li></ul><h5><strong>17:10 – 17:40 &nbsp;Rybářské hospodaření jako významný faktor ovlivňující rybí společenstva v pstruhových vodách</strong></h5><ul><li>Tomáš Randák, FROV JČU</li></ul><h5><strong>17:40 – 18:00 &nbsp;Jak nám může (ne)vonět voda</strong></h5><ul><li>Emil Janeček, Povodí Ohře, s.p.</li></ul><h5><strong>18:00 Ukončení prvního dne setkání.</strong></h5><h5><strong>18:30</strong> Společenský večer, raut</h5><h4><strong>Pátek 6. února</strong></h4><h5><strong>8:00 – 9:00 </strong>Snídaně v prostorách UJEP</h5><h5><strong>9:00 – 9:30 &nbsp;Důlní jezera Milada a Most: cizorodé látky v makrořasách Vaucheria</strong></h5><ul><li>Kateřina Grabicová a kol., FROV JČU</li></ul><h5><strong>9:30 – 10:00 &nbsp;Řasové louky: bioremediační technologie pro ekologickou obnovu vodních biotopů</strong></h5><ul><li>Klára Řeháková a kol., Biologické Centrum AV ČR, HBÚ</li></ul><h5><strong>10:00 – 10:30 &nbsp;Řasové technologie pro rekultivaci</strong></h5><ul><li>Kateřina Čapková a kol, Biologické Centrum AV ČR, HBÚ</li></ul><h5><strong>10:30 – 11:00 Potenciál řas v recyklaci prvků vzácných zemin a remediaci prostředí</strong></h5><ul><li>Mária Čížková a kol, Botanický ústav AV ČR</li></ul><h5><strong>11:00 – 11:30 Výskyt pesticidů a léčiv v přehradních sedimentech</strong></h5><ul><li>Sylvie Kříženecká, FŽP UJEP</li></ul><h5><strong>11:30 – 11:45 Cestování za mikroplasty</strong></h5><ul><li>&nbsp; Hana Burdová, FSI UJEP</li></ul><h5><strong>11:30 – 12:30 </strong>Oběd</h5><h5><strong>12:30 – 14:30 Moderovaná diskuse na témata SeBiChem 2026</strong></h5><h5><strong>14:30 Ukončení setkání</strong></h5><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=dgS2fx4dGAE"><strong>Livestream z prvního dne</strong></a></p></blockquote><p>Konference SeBiChem 2026 bude realizována za <strong>podpory projektu IDEAL</strong>. Podrobnosti o tomto projektu je možné nalézt na stránkách:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://ideal-sncz.eu/cs/instroduction/"><strong>https://lnkd.in/eHdE5sFf</strong></a></li></ul><h4><strong>A také za podpory těchto firem:</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/59"><strong>Watrex Praha, s. r. o.</strong></a></li><li>AMEDIS, s. r. o.</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/176"><strong>METROHM Česká republika, s. r. o.</strong></a></li><li>Donau Lab, s. r. o.</li></ul><h4><strong>S mediální podporou od:</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/1"><strong>portálu Labrulez&nbsp;</strong></a></li><li>časopisu Chemagazín</li></ul>

On-line stream a program odborného setkání SeBiChem 2026

<p><strong>Vědci z Ústavu organické chemie a biochemie AV ČR pronikají do detailů genové transkripce. Popsali dosud neznámý molekulární mechanismus, kterým může začínat přepis genetické informace z deoxyribonukleové kyseliny (DNA) do ribonukleové kyseliny (RNA). Zaměřili se na zvláštní molekuly nazývané alarmony, které se vyskytují v buňkách napříč organismy a jejichž hladina se často zvyšuje při buněčném stresu. Výsledky výzkumu zveřejnil prestižní vědecký časopis </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="ÚOCHB/Tomáš Belloň: Výzkum z ÚOCHB odhaluje dosud nepoznaný způsob přepisu genetické informace: Dr. Hana Cahová, vedoucí vědecké skupiny Chemická biologie nukleových kyselin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>RNA molekuly mohou nést na jednom konci různé chemické modifikace, označované jako tzv. „čepičky“. U eukaryotních organismů, kam patří i lidské buňky, je nejznámější čepička, která se podílí na stabilitě RNA a regulaci jejího dalšího osudu. V posledních letech se však ukazuje, že existují i alternativní, nekanonické RNA čepičky, jejichž vznik a mechanismus připojení k RNA se zatím vymyká lidským znalostem. Mezi ně patří například tzv. alarmonové čepičky, tvořené molekulami dinukleosidpolyfosfátu, alarmonů, které chrání buněčnou RNA ve chvílích, kdy je buňka v ohrožení.</p><p>Tým <a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/cs"><strong>Dr. Hany Cahové</strong></a> se ve své studii zaměřil na RNA polymerázu z bakterií a sledoval, jakým způsobem může tento enzym zahájit transkripci za využití dinukleosidpolyfosfátů (NpNs) místo běžných stavebních bloků RNA. Vědci vůbec poprvé popsali na atomární úrovni, jak může vznikat RNA s alarmonovou čepičkou přímo při zahájení přepisu genu. Navíc pozorovali, že se Np<sub>n</sub>Ns vážou jiným typem párování, než je obvyklé.</p><p>Na práci se zásadně podílely <strong>Valentina Serianni z týmu Hany Cahové</strong>, která prokázala schopnost dinukleosidpolyfosfátů zahajovat přepis genu, a<strong> Jana Škerlová</strong>, která se zaměřila na strukturální analýzu RNA polymerázy a na základě dat z kryogenní elektronové mikroskopie ukázala, jak se molekuly dinukleosidpolyfosfátů váží do aktivního místa RNA polymerázy, tedy do srdce enzymu, kde se genetická informace přepisuje. Jejich studie pomáhá odhalovat procesy, které provázejí přepis genetické informace z DNA do RNA.</p><p>Hana Cahová k tomu dodává: <i>„Popisujeme něco, co se v buňkách skutečně děje a co nyní dokážeme pozorovat přímo na úrovni jednotlivých molekul. Získáváme tak odpovědi na zásadní otázky týkající se buněčných procesů, například jak se buňky přizpůsobují stresu. Právě RNA totiž přenáší kaskádu informací, které stojí za jakoukoli buněčnou reakcí, např. na stav ohrožení způsobený nedostatkem živin či teplotním šokem.“</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="ÚOCHB/Tomáš Belloň: Výzkum z ÚOCHB odhaluje dosud nepoznaný způsob přepisu genetické informace: Dr. Tomáš Kouba, vedoucí core facillity skupiny Kryogenní elektronová mikroskopie." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Klíčovou roli v projektu sehrála kryogenní elektronová mikroskopie (cryo-EM), kterou ved<strong>l Dr. Tomáš Kouba</strong>, jeden z autorů článku. <i>„Kryoelektronová mikroskopie umožňuje zmrazit biologické molekuly skoro v jejich přirozené formě a následné získat trojrozměrnou strukturu takových molekul. Díky tomu můžeme nahlédnout přímo do aktivního centra enzymů a sledovat jejich fungování až na atomární úrovni,“ </i>vysvětluje Tomáš Kouba.</p><p>ÚOCHB vloni otevřel nové<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/cs"><strong>centrum cryo-EM</strong></a>, které je v českém prostředí unikátní. Špičkové kryogenní elektronové mikroskopy našly zázemí ve speciálně navržené budově a umožňují studium biologických procesů s mimořádnou strukturální přesností.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="ÚOCHB: Výzkum z ÚOCHB odhaluje dosud nepoznaný způsob přepisu genetické informace: Tato práce ukazuje, jak malé molekuly NpnN pomáhají bakteriím zahájit přepis genetické informace. Detailní zobrazení pomocí kryogenní elektronové mikroskopie odhaluje, jak se vážou na genetickou šablonu a fungují jako nekanonické „čepičky“ RNA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>Původní článek</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5#citeas"><strong>Molekulární vhled do 5′ zakončení RNA pomocí Np</strong><i><strong><sub>n</sub></strong></i><strong>Ns zprostředkovaného bakteriální RNA polymerázou</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p><strong>Nat. Chem. Biol.</strong> <strong>21</strong> (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstrakt</strong></h4><p>RNA zakončená dinukleosidovými polyfosfáty byla u bakterií i eukaryot objevena teprve nedávno. Pravděpodobný mechanismus tohoto specifického typu zakončení RNA spočívá v přímém začlenění dinukleosidových polyfosfátů RNA polymerázou jako nekanonických iniciačních nukleotidů. Dosud však nebylo známo, jakým způsobem se tyto sloučeniny vážou do aktivního místa RNA polymerázy během zahájení transkripce. V této práci jsme in vitro studovali iniciaci transkripce za použití série DNA templátů v kombinaci s dinukleosidovými polyfosfáty a modelovou RNA polymerázou z bakterie <i>Thermus thermophilus</i>. Zjistili jsme, že místo zahájení transkripce se může lišit v závislosti na kompatibilitě konkrétního templátu a použitého dinukleosidového polyfosfátu. Struktury iniciačních transkripčních komplexů s dinukleosidovými polyfosfáty získané pomocí kryogenní elektronové mikroskopie odhalily, že obě nukleové báze v molekule mohou párovat s DNA templátem. První kódovaný nukleotid se páruje kanonickým Watsonovým–Crickovým způsobem, zatímco druhá nukleová báze se váže nekanonicky prostřednictvím reverzního Watsonova–Crickova párování. Tato práce tak poskytuje strukturní vysvětlení mechanismu, kterým dinukleosidové polyfosfáty zahajují transkripci RNA.</p></div></div>

Výzkum z ÚOCHB odhaluje dosud nepoznaný způsob přepisu genetické informace

<p>🎤 <strong>Přednášející: Michal Belianský</strong></p><h3><strong>VIZE 2025: Empower Method Validation Manager</strong></h3><h4><strong>Empower Method Validation Manager (MVM): moderní přístup k validaci chromatografických metod</strong></h4><p>Validace analytických metod je klíčovým požadavkem regulovaných laboratoří v oblasti farmacie, biotechnologií i kontroly kvality. Software <strong>Empower Method Validation Manager (MVM)</strong> od společnosti Waters představuje komplexní nástroj, který umožňuje provádět validaci chromatografických metod systematicky a plně v souladu s požadavky lékopisů a regulačních autorit.</p><p>MVM je rozšířením chromatografického datového systému <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/products/627"><strong>Empower</strong></a>, díky čemuž propojuje vývoj, validaci, zpracování dat i reporting do jednoho uceleného workflow.</p><h4><strong>Automatizované výpočty a System Suitability</strong></h4><p>Jednou z hlavních výhod Empower MVM je využití <strong>automaticky generovaných chromatografických parametrů</strong>, jako jsou:</p><ul><li>rozlišení (Resolution),</li><li>faktor symetrie a tailing,</li><li>počet teoretických pater (Plate Count),</li><li>výška a šířka píku,</li><li>poměr signál/šum (S/N).</li></ul><p>Tyto parametry jsou vyhodnocovány v souladu s požadavky <strong>USP, EP i JP</strong> a mohou být přímo použity v rámci testů <strong>System Suitability</strong>, čímž se minimalizuje riziko manuálních chyb a zvyšuje konzistence výsledků.</p><h4><strong>Podpora chemických struktur a specifických aplikací</strong></h4><p>Empower MVM nabízí také rozšíření <strong>Chemical Structures</strong>, které je integrováno ve spolupráci s ACD/Labs. Díky tomu lze přímo v prostředí Empoweru:</p><ul><li>kreslit a upravovat chemické struktury,</li><li>vytvářet knihovny sloučenin,</li><li>vkládat struktury do tabulek komponent a zahrnovat je do reportů.</li></ul><p>Další specializovaná rozšíření pokrývají například:</p><ul><li><strong>Dissolution</strong> – automatizované vyhodnocení disolučních testů včetně výpočtů f1, f2 a Q faktoru,</li><li><strong>GPC/SEC pro polymerní analýzu</strong> – výpočty molekulových hmotností (Mw, Mn, Mp, Mz) a kombinaci dat z RI a LS detektorů,</li><li><strong>Sample Weight Importer</strong> – přímý přenos hmotností ze vah do Empoweru s plnou auditní stopou.</li></ul><h4><strong>Validace metod krok za krokem v MVM</strong></h4><p>Empower Method Validation Manager strukturuje validaci do tří hlavních fází:</p><ol><li><strong>Validation Protocol</strong><br>Definice validačních požadavků, akceptačních kritérií, typů testů a schvalovacích procesů.</li><li><strong>Validation Study</strong><br>Řízení celé validační studie v jednom projektu – akvizice dat, jejich zpracování, statistické výpočty a průběžné hodnocení souladu s kritérii.</li><li><strong>Reporting</strong><br>Automatizovaná tvorba validačních reportů z předdefinovaných šablon, včetně elektronických podpisů a plné sledovatelnosti změn.</li></ol><p>Software podporuje všechny klíčové validační testy, jako jsou linearita, přesnost, správnost, specificita, LOD/LOQ, opakovatelnost, mezilehlá přesnost, robustnost či stabilita metody</p><h4><strong>Integrace, migrace dat a monitoring systémů</strong></h4><p>Součástí ekosystému Empoweru jsou i nástroje pro <strong>migraci dat z jiných CDS</strong> (např. Agilent ChemStation/OpenLab, Thermo Chromeleon, MassLynx) pomocí modulu <strong>Waters Data Converter</strong>.</p><p>Díky platformě <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/products/1544"><strong>waters_connect</strong></a><strong> System Monitoring</strong> mají uživatelé přehled o stovkách chromatografických a LC-MS systémů, mohou sledovat jejich stav v reálném čase, dostávat automatické notifikace a efektivně plánovat využití přístrojů, což významně zvyšuje produktivitu laboratoře.</p><h4><strong>Závěr</strong></h4><p>Empower Method Validation Manager představuje robustní a regulatorně připravené řešení pro validaci chromatografických metod od A do Z. Automatizace výpočtů, jednotné řízení validačních studií, pokročilé reportingové nástroje a hluboká integrace s CDS Empower činí z MVM silný nástroj pro laboratoře, které kladou důraz na kvalitu dat, efektivitu práce a plnou shodu s regulačními požadavky.</p>

Waters VIZE 2025: Empower Method Validation Manager

Přednáška

Věda a výzkum

Video

Článek

Produkt

Nejbližší akce

ÚOCHB AV ČR je přední mezinárodně uznávaná vědecká instituce, jejímž hlavním posláním je základní výzkum v oblasti chemické biologie a medicinální chemie, organické a materiálové chemie, chemie přírodních látek, biochemie a molekulární biologie, fyzikální chemie, teoretické chemie a analytické chemie.

Ústav organické chemie a biochemie AV ČR

Setkání odborníků z oblasti biologie a chemie vodních ekosystémů pod záštitou Povodí Ohře, s. p., jehož cílem je najít společná témata a navázat vzájemnou mezioborovou spolupráci.

SeBiChem

Firmu Waters založil v roce 1958 pan James Waters. Od té doby se společnost Waters specializuje na kapalinovou chromatografii a hmotnostní spektrometrii. Divize TA Instruments působí na poli termální analýzy. V České republice je Waters zastoupen přímou pobočkou, která sídlí v Praze.

Waters Gesellschaft

Separation Science

Agilent Technologies

Bruker

Altium International (HPST)

Shimadzu Corporation

Plasmion

Spectroscopy & Separation Science

<h3><strong>Direct screening enables fast identification and comparison of substances</strong></h3>
<p>Fast &amp; Direct Screening enables to identify or compare different substances without any sample preparation.</p>
<h3><strong>Screening with quantification delivers reliable concentration levels</strong></h3>
<p>Screening with quantification not only enables a fast identification of substances but also provides reliable information about concentration levels to compare with standards or thresholds.</p>
<h3><strong>Automated all-in-one workflow simplifies routine analytics</strong></h3>
<p>All-in-one-Workflow reduces effort and cost in routine analytics as it enables to only perform detailed GC-MS analysis for positively screened samples.</p>
<h4><strong>Conventional Ionization Technologies</strong></h4>
<p>With conventional atmospheric pressure methods, the ions are mostly <strong>formed outside the inlet of an MS</strong>. This implies that the substance to be analyzed (e.g. coffee) cannot be analyzed directly, but is usually &quot;sprayed&quot; into the MS in the form of a sample (liquid extract) via the ionization source.</p>
<h4><strong>SICRIT® Technology</strong></h4>
<p>The SICRIT® (Soft Ionization by Chemical Reaction In Transfer) ionization source is <strong>interfaced with</strong> the atmospheric pressure <strong>inlet of the MS</strong> and ionizes every substance which is drawn into the MS by its inherent vacuum.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Plasmion_Conventional_MS_Ionization_Technologies_vs_SICRIT_Technology_8999716e25/Plasmion-Conventional-MS-Ionization-Technologies-vs.-SICRIT(r)-Technology.png" alt="Plasmion: Conventional MS Ionization Technologies vs. SICRIT® Technology"/></p>
<h4><strong>SICRIT® Characteristics</strong></h4>
<ul>
<li>Simple extension of MS inlet</li>
<li>Concentric dielectric barrier discharge</li>
<li>Sample ionized during transfer into MS</li>
<li>Soft ionization by proton transfer and UV light</li>
<li>No consumables</li>
</ul>


Plasmion: Direct MS Screening - Get Results Faster with SICRIT

Direct MS Screening - Get Results Faster with SICRIT

<p><strong>Agilent and GERSTEL are happy to host this 4-day live virtual seminar discussing how you can assure safety, authenticity, and quality of alcoholic beverages. The focus will be on sharing the latest in technology developments and capabilities, new applications, and customer stories. Topics include spirits, wine, beer, and cider.  There is something for everyone in this seminar series and we are glad to see you here.</strong></p>
<h3><strong>Presentation 1: Characterizing free and bound monoterpene alcohols in wine fermentations</strong></h3>
<ul>
<li><strong>Presenter: Prof. Susan Ebeler</strong> (Professor, Department of Viticulture and Enology, University of California, Davis)</li>
<li><strong>Presenter: Dr. Larry Lerno</strong> (Director, Food Safety and Measurement Facility, University of California, Davis)</li>
</ul>
<p>Monoterpenes and their glycosidically boud pre-cursors contribute important aroma characteristics to many grape and wine varieties. This presentation will describe multi-dimensional approaches to characterize free and glycosidically-bound monoterpenes in grapes and wines. Glycosidically-bound terpenes are isolated from grapes and the aglycones identified by hydrolysis followed by SPME-GC/MS. The intact glycosides are tentatively identified by ultrahigh performance liquid chromatography quadrupole time of flight mass spectrometry (UHPLC-QTOF/MS). This work enhances understanding of the ways that monoterpenyl glycosides contribute to grape and wine volatile aroma composition.</p>
<h5><strong>Key Learning Objectives/What attendees will learn:</strong></h5>
<ul>
<li>Role of free and glycosidically bound monoterpenes on grape and wine aroma and flavor.</li>
<li>Analytical approaches using SPME-GC/MS and UHPLC-QTOF/MS to identify and monitor glycosidically-bound monoterpenes in grapes and wines.</li>
<li>Information about impacts of fermentation conditions on glycosidically-bound monoterpenes in wine</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<p>Analytical chemists, food and wine chemists, anyone with interest in food and wine flavor and aroma</p>
<h3><strong>Presentation 2: Solventless Extraction Techniques for the Analysis of Wine</strong></h3>
<ul>
<li><strong>Presenter: Dr. John Stuff</strong> (Manager, Analytical Services Group, GERSTEL)</li>
</ul>
<p>This talk will focus on solventless extraction techniques for the analysis of wines. Examples of each technique will be presented. The advantages and disadvantages of each technique will be discussed.</p>
<h5><strong>Key Learning Objectives/What attendees will learn:</strong></h5>
<ul>
<li>Different solventless extraction techniques for the analysis of beverages</li>
<li>Advantages and disadvantages of each technique</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<p>Anyone involved in the analysis of beverages, food, flavor or fragrances</p>
<h3><strong>Presentation 3: Effect of Winemaking on Element Profiles and Arsenic Species</strong></h3>
<ul>
<li><strong>Presenter: Dr. Jenny Nelson</strong> (Applications Scientist, Agilent Technologies)</li>
</ul>
<p>Metals and minerals play important roles in the production of wine and can impact the overall quality of the finished product. Although a wine’s element content is known to be influenced by environmental conditions originating in the vineyard, it is not entirely understood how winemaking processes impact the final metal concentrations. After a long 2 year study, we are ready to share findings on metals and minerals role in the production of wine and the impact on overall quality. The elemental content of wine is known to be influenced by environmental conditions originating at the vineyard, however, it is not known how winemaking processes impact the final metal concentrations.</p>
<h5><strong>Key Learning Objectives/What attendees will learn:</strong></h5>
<ul>
<li>How metals and minerals play an important role in the production of wine.</li>
<li>How to use elemental fingerprinting for the geographic determination of wine.</li>
<li>How ICP-MS is used in the wine industry.</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<p>Anyone interested in elemental analysis of wine</p>
<blockquote>
<p><strong>Presenter: Prof. Susan Ebeler (Professor, Department of Viticulture and Enology, University of California, Davis)</strong></p>
</blockquote>
<blockquote>
<p>Dr. Ebeler is a professor in the Department of Viticulture and Enology at UC Davis. She seeks to answer questions about food and beverage flavor, quality and health effects, using analytical tools including gas chromatography-mass spectrometry, and high-performance liquid chromatography-mass spectrometry, to study the effects of agricultural practices, fermentation, processing, and storage on composition of grapes, wines, and other foods and beverages.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Larry Lerno, PhD (Director, Food Safety and Measurement Facility, University of California, Davis)</strong></p>
</blockquote>
<blockquote>
<p>Dr. Lerno is a specialist in the Department of Viticulture and Enology at UC Davis where he serves as the Director of Research of the UC Davis Food Safety and Measurement Facility. Dr. Lerno uses gas and liquid chromatography coupled to mass spectrometric detectors to explore the aroma, flavor, and taste compounds in foods and beverages and how agricultural, processing, and environmental factors may effect these compounds.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: John Stuff, PhD (Manager, Analytical Services Group, GERSTEL)</strong></p>
</blockquote>
<blockquote>
<p>Dr. Stuff’s is currently Manager of the Analytical Services Group with GERSTEL, Inc in Baltimore, MD. He is responsible for methods development for sample preparation and introduction for gas chromatography-mass spectrometry. He develops and teaches customer training classes, gives seminars and posters at national and international meetings, conducts new product testing, and supports pre- and post-sales opportunities. He provides expert analytical support to a wide customer base including, food, flavor, fragrance, forensic, environmental, and chemical industries.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Jenny Nelson, PhD (Application Scientist, Agilent Technologies, Inc.)</strong></p>
</blockquote>
<blockquote>
<p>Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Chemist for the Life Science and Chemical Analysis team at Agilent Technologies, joining in 2012 (with a step away in 2019). Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at University of California, Davis since 2013. Jenny has been very active with AOAC and ASTM over the past 8 years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry.</p>
</blockquote>


Agilent Technologies: Alcoholic Beverages Virtual Seminar

Alcoholic Beverages Virtual Seminar - Wine

Characterizing free and bound monoterpene alcohols in wine fermentations & Solventless Extraction Techniques & Element Profiles and Arsenic Species.

<p><strong>Agilent and GERSTEL are happy to host this 4-day live virtual seminar discussing how you can assure safety, authenticity, and quality of alcoholic beverages. The focus will be on sharing the latest in technology developments and capabilities, new applications, and customer stories. Topics include spirits, wine, beer, and cider.  There is something for everyone in this seminar series and we are glad to see you here.</strong></p>
<h3><strong>Presentation 1: Identification of Markers of Consumer Acceptability in Lager Beer</strong></h3>
<ul>
<li><strong>Presenter: Benjamin Gelinas</strong> (Postdoctoral Researcher, Ohio State University)</li>
</ul>
<p>Beer remains the largest alcoholic beverage category in terms of volume of consumption, with lager beer being the largest style. An un-targeted flavoromics approach coupling consumer acceptability ratings of 15 lager beers was used to identify markers of consumer acceptability in beer. Top variables of importance were isolated, quantified, and identified prior to recombination studies to demonstrate the effect of these compounds on consumer acceptance and preference.</p>
<h5><strong>Key Learning Objectives/What attendees will learn:</strong></h5>
<ul>
<li>Improved understanding of chemical drivers of beer on acceptance</li>
<li>Improved understanding of the role of iso-humulones on bitterness in beer</li>
<li>Implications of ingredients and processing on flavor and consumer acceptance</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<p>Personnel involved in the production of lager beer or lager beer ingredients</p>
<h3><strong>Presentation 2: LC-MS Analysis of Hop-Derived Humulone Constituents in Beer</strong></h3>
<ul>
<li><strong>Presenter: Prof. Bruce C. Hamper</strong> (Associate Teaching Professor, University of Missouri – St. Louis)</li>
</ul>
<p>Hops are essential ingredients for the brewing of beer, providing bitter flavors, desirable taste and hops aroma in the final product. The contribution of humulones and related components in hops to bitter flavors in beer is dependent on numerous factors including the quality, variety and quantity of hops used, specific addition protocols during the brewing recipe, nature of other ingredients and details of the brewing process.  Liquid chromatography-mass spectrometry (LC-MS) using electrospray ionization coupled with selective ion monitoring (SIM-MS) is particularly useful for profiling the compounds obtained from hops utilization during brewing.  Small scale brews from university brewing courses can be compared and evaluated in an efficient manner. </p>
<h5><strong>Key Learning Objectives/What attendees will learn:</strong></h5>
<ul>
<li>Importance of LC-MS using selective ion monitoring for rapid analysis of complex samples.</li>
<li>Impact of key ingredients used in the brewing of beer on beer flavor.</li>
<li>Key features of hops components and their contribution to beer bitterness.</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<p>This webcast will be of interest to scientists using analytical techniques for measurement of multiple components in complex mixtures.  Focusing on food analysis provides intriguing examples that can relate to everyday experience and capture the imagination.  Science educators will be interested in the application of these techniques to classroom and laboratory exercises.</p>
<h3><strong>Presentation 3: A HS-SPME Arrow/GC-MS Method for Determination of Smoke Taint-Related Volatile Phenols in Humulus lupulus</strong></h3>
<ul>
<li><strong>Presenter: Stacey Williams</strong> (Senior Chemist, New Belgium Brewing Company)</li>
<li><strong>Presenter: Justin Alexander</strong> (Analytical Chemist, New Belgium Brewing Company)</li>
</ul>
<p>With a record-breaking fire season across the Western US, an unknown number of food crops were exposed to significant quantities of smoke. Due to the length of the season, Humulus lupulus (hops) were exposed to smoke prior to harvest and during processing. Guaiacol and 4-methylguaiacol (4MG) are routinely used as markers to determine the extent of smoke-taint in the wine industry. Quantitating these compounds in smoke-exposed hops prior to use in the brewing process is needed to predict the likelihood of perceptible smoke taint in finished beer. This presentation encompasses the validated analytical method to accurately quantitate unbound guaiacol and 4-methylguaiacol in smoke-exposed hops.</p>
<h5><strong>Key Learning Objectives/What attendees will learn:</strong></h5>
<ul>
<li>Potential challenges in the raw material supply chain for the brewing industry</li>
<li>Validation of an analytical method</li>
<li>The impact of high aroma active volatiles (i.e., phenols) to beer</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<p>Anyone interested in potential wildfire risks to food crops, especially those handling raw materials used in the brewing industry</p>
<blockquote>
<p><strong>Presenter: Benjamin Gelinas (Postdoctoral Researcher, Ohio State University)</strong></p>
</blockquote>
<blockquote>
<p>Ben Gelinas is a postdoctoral researcher at Ohio State University whose primary research focuses on Beer and Beer acceptability. Ben’s background is in analytical flavor chemistry working at the Flavor Research and Education Center at Ohio State University.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Prof. Bruce C. Hamper (Associate Teaching Professor, University of Missouri – St. Louis)</strong></p>
</blockquote>
<blockquote>
<p>Prof. Bruce Hamper teaches courses in brewing science and general chemistry at the University of Missouri-St. Louis. He leads a research group investigating synthesis and analysis of organic compounds and potential pharmaceutical agents. Current research includes development of synthetic methods for preparation of biomolecules using continuous flow processing. His group is also involved in development of analytical methods for profiling components in fermented beverages.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Stacey Williams (Senior Chemist, New Belgium Brewing Company)</strong></p>
</blockquote>
<blockquote>
<p>Stacey Williams earned a BS in Chemistry at Metropolitan State College in Denver. She has extensive experience in high performance liquid chromatography (HPLC), gas chromatography (GC) and mass spectrometry through her work in pharma, biopharma and the beer industry. She is currently a principal scientist at New Belgium in the QA lab with responsibilities including method development, validation, gas chromatography - olfactory (GC-O) and instrument troubleshooting.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Justin Alexander (Analytical Chemist, New Belgium Brewing Company)</strong></p>
</blockquote>
<blockquote>
<p>Justin Alexander graduated from Colorado State University with a Bachelor of Science in Fermentation Science &amp; Technology with a Minor in Food Science &amp; Safety. He has multiple years of experience in ultra-performance liquid chromatography (UPLC), primarily focusing on hop bittering components, organic acids, and fermentable carbohydrates. He currently holds a Scientist role in Quality Assurance at New Belgium Brewing Company in the Analytical Chemistry Lab.</p>
</blockquote>


Alcoholic Beverages Virtual Seminar - Beer

Markers of Consumer Acceptability in Lager Beer & LC-MS Hop-Derived Humulone Constituents in Beer & HS-SPME Arrow/GC-MS of Smoke Taint-Related Volatile Phenols.

<p><strong>Per- and polyfluoroalkyl substances (PFAS), an emerging class of toxic anthropogenic chemicals persistent in the environment, are currently regulated at the low part-per-trillion level worldwide in drinking water. Quantification and screening of these compounds currently rely primarily on liquid chromatography mass spectrometry (LC-MS).</strong></p>
<p>To better meet the regulatory demands of rapid screening of these chemicals, the hyphenating of solid phase microextraction (SPME) with direct analysis in real time (DART) will be demonstrated. PFAS analysis screened rapidly by DART on the Bruker EVOQ triple quadrupole using LC free workflows demonstrates a significant increase in productivity whilst also presenting a more economical and a greener solution for the lab.</p>
<p>Join us live for the real-time analysis of PFAS with SPME-DART-MS and discover the power of our cutting-edge instrumentation and technologies. </p>
<blockquote>
<p><strong>Presenter:</strong> William Fatigante (Applications Scientist, DART-MS at Bruker Applied Mass Spectrometry)</p>
</blockquote>


Bruker Applied Mass Spectrometry - Chromatography-Free Screening of PFAS Enabled Through SPME-DART-MS

Chromatography-Free Screening of PFAS Enabled Through SPME-DART-MS

Screening of PFAS Enabled Through SPME-DART-MS

<h4><strong>PFAS in Focus</strong></h4><p><strong>Welcome to the PFAS in Focus, a comprehensive and exclusive 10-parts webinar series sponsored by Shimadzu, covering the basics and beyond about the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in the environment. In these five webinars, our experts will demonstrate the suitability of various analytical techniques, such as LCMS, GCMS, CIC, and QTOF, for PFAS testing.</strong></p><p>Join our experts, live or on-demand after the original air date, to demystify the challenges of PFAS analysis and <strong>gain the insights you need to</strong>:</p><ul><li>Manage PFAS contamination in your laboratory.</li><li>Master standardized methods for PFAS testing.</li><li>Discover new analytical workflows to maximize the performance of your instruments (LC-MS/MS, GCMS, CIC, QTOF) for PFAS analysis.</li></ul><h5><strong>Who should attend:</strong></h5><ul><li><strong>Environmental industry professionals</strong> and academics currently working on PFAS analysis or looking to establish the application in their labs.</li><li><strong>Representatives </strong>from drinking and wastewater utilities.</li><li><strong>LC–MS users </strong>from any field interested in expanding their applications to include PFAS testing.</li></ul><h4><strong>Part 02: Leveraging GC-MS and CIC as Complementary Techniques to LC-MS for a Comprehensive PFAS Solution</strong></h4><p><strong>The demand for per and polyfluoroalkyl substances (PFAS) analysis is growing. To date, there are several standardized PFAS methods. Most of these methods are based on Liquid Chromatography/Mass Spectrometry (LC/MS) techniques. However, LC/MS is not suitable to analyze all PFAS compounds because of the diverse physicochemical properties of chemicals within the PFAS family. Gas Chromatography/Mass Spectrometry GC/MS as a complementary technique can address volatile PFAS compounds that are challenging to be analyzed by LC/MS.&nbsp;</strong></p><p>In this webinar, a Head-Space Solid Phase Microextraction-Triple Quadrupole Gas Chromatography/Mass Spectrometry (HS-SPME GC/MS/MS) analytical method is used to analyze volatile PFAS in water. In addition, we will discuss Adsorbable Organic Fluoride (AOF) analysis by Combustion Ion Chromatography (CIC). This method provides information on the total amount of PFAS that may not be targeted by other selective chromatography methods.</p><p>We will host a Q&amp;A session after the presentation to address any questions or comments.</p><blockquote><p><strong>Presenter: </strong>Andy Sandy (GCMS Application Scientist, Shimadzu Scientific Instruments)</p><p>Andy Sandy is a Gas chromatography-Mass Spectrometry (GC-MS) Applications Scientist at Shimadzu Scientific Instruments, USA. In 2016, he joined the company. At Shimadzu he is a part of a dynamic application group, which is responsible for developing applications that provide solutions to complex analytical issues. Prior to working at Shimadzu, he completed a post-doctoral study at University of Illinois at Chicago, where he focused on developing environmental analytical methods for identifying and measuring emerging contaminant in the environment.</p><p><strong>Presenter:&nbsp;</strong>Andriy Savka (Shimadzu Scientific Instruments)</p><p>Andriy is an accomplished Product Specialist in the HPLC product group at Shimadzu Scientific Instruments, specializing in Ion Chromatography and other HPLC applications. He developed his chromatography expertise through roles in the pharmaceutical industry and Shimadzu's service team. In his current role within the HPLC group at headquarters, he works on various IC projects providing technical support for customers and developing IC applications for environmental, chemical, and other markets. He combines his technical and scientific background with his emerging business acumen to align product development with market needs, thereby enhancing customer satisfaction. Andriy holds a bachelor’s degree in chemistry from Saint Joseph's University and is currently pursuing an MBA at the University of Maryland Global Campus, with anticipated graduation in March 2025.</p><p><strong>Presenter:&nbsp;</strong>Alan Owens (GC &amp; GCMS Product Manager, Shimadzu Scientific Instruments)</p><p>Alan Owens is the GC and GCMS Product Manager at Shimadzu Scientific Instruments. Alan received his B.S. degree in Biology and Chemistry from Hampden-Sydney college. He then joined Shimadzu as a GCMS Product Specialist at the corporate headquarters in Columbia, MD. Before his time with Shimadzu, he comes from a flavor and fragrance background with expertise in advanced sample introduction techniques such as SPME and Dynamic headspace. He has since expanded into all sample introduction techniques specifically tailored towards Pyrolysis with a heavy influence of plastics and polymers.</p></blockquote>

Leveraging GC-MS and CIC as Complementary Techniques to LC-MS for a Comprehensive PFAS Solution

In this webinar, a HS-SPME GC/MS/MS analytical method is used to analyze volatile PFAS in water. 

GC-MS and CIC as Complementary Techniques to LC-MS for PFAS

<p><strong>There is increased concern regarding the authenticity of basmati rice throughout the world. For years, traders have been passing off a lesser quality rice as the world&#39;s finest long-grained, aromatic rice, basmati, in key markets like the US, Canada and the EU.</strong></p>
<p>In this on-demand webinar, we describe a proof of principle method to assess the authenticity of basmati rice using the latest advancements in high resolution GC-MS and informatics technologies. Volatile compounds of interest were extracted from heated dry rice via SPME and headspace. Following a generic GC separation, detection was performed using a SYNAPT G2-Si MS run in HDMSE mode. Collection of a HDMSE dataset offers a high level of specificity owing to the orthogonal nature of the ion mobility separation to the GC separation.</p>
<p>Progenesis QI, the latest OMICS informatics package from Waters, is designed to utilize the 4-dimensional data produced during a SYNAPT G2-Si HDMSE acquisition. Initially, alignment of all injections was performed followed by the unique peak co-detection process resulting in the same number of analyte measurements in every sample and no missing values. Data from all isotopes and adducts of a parent compound were then deconvoluted giving a single robust and accurate quantitative measurement for that parent compound. The peak picking and deconvolution algorithms ensure a high quality compound table where adducts and isotopes are grouped with the parent m/z. Compounds of interest from the rice samples were highlighted using various multivariate statistical techniques such as PCA and identified using elucidation tools and relevant database searches within the software platform.</p>
<p>This workflow has general applicability to many areas of discovery OMICS and food research where biomarkers differentiating between two or multiple groups are required.</p>
<h3><strong>What will I learn?</strong></h3>
<ul>
<li>An experimental workflow to evaluate the authenticity of foodstuffs</li>
<li>A basic workflow for the discovery of volatile biomarkers between multiple groups of samples</li>
<li>The basics of HDMSE data independent acquisition</li>
<li>How Progenesis QI is used to analyze metabolomics data</li>
</ul>
<h3><strong>Who should attend?</strong></h3>
<ul>
<li>Food research scientists</li>
<li>Metabolomics research scientists</li>
<li>Biomarker research scientists</li>
</ul>
<blockquote>
<p><strong>Presenter: Robert Tonge, Ph.D. (Senior Product Manager, OMICS Informatics, Waters Corporation)</strong></p>
</blockquote>
<blockquote>
<p>Dr Robert Tonge is Senior Product Manager for OMICS Informatics at Waters Corporation, Manchester UK. Robert has been at Waters for 4 years in both Product Development and Field Marketing and has approaching 20 years experience in OMICS science. He trained initially in Biochemistry and Toxicology before moving to &#39;Big Pharma&#39; where he worked in Discovery and Translational Research across a wide variety of disease areas from cancer, cardiovascular disease and infection research.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Gareth Cleland, Ph.D. (Principal Scientist, Food &amp; Environmental Business, Waters Corporation)</strong></p>
</blockquote>
<blockquote>
<p>Dr Gareth Cleland is a Principal Scientist within the Food and Environment Business Operations at Waters Headquarters, USA. Following his Chemistry studies, he started his professional career working as a Development Chemist for a small coatings company in Oxfordshire, UK. He joined Waters Corporation in 2002 and has held various roles within the organization, both UK and US based, over the last 12 years.</p>
</blockquote>


Pixabay/Trung Hieu Dang: Discovery OMICS and Progenesis QI for Food Authenticity Testing

Discovery OMICS and Progenesis QI for Food Authenticity Testing

<ul>
<li><p><strong>Jednoduchá a účinná filtrace vzorků – novinky z portfolia Agilent Technologies a jak využívat funkce e-shopu HPST.</strong> (R. Kukula) - 14.5.2020</p>
</li>
<li><p><strong>Moderní metody přípravy vzorků a odstranění lipidů ze vzorku.</strong> (P.Hubena) - 28.5.2020</p>
</li>
<li><p><strong>Solid Phase Microextraction – inovované řešení od Agilent.</strong> (J. Berková) - 11.6.2020</p>
</li>
<li><p><strong>Stříkačkové a peristaltické pumpy.</strong> (I. Palíková) - 18.6.2020</p>
</li>
</ul>


HPST: Série webinářů o spotřebním materiálu

Série webinářů o spotřebním materiálu

<p><strong>Food samples that are fatty/oily, dried or highly complex matrices often pose challenges in the analytical process. Therefore, an efficient sample preparation providing a reliable removal or suppression of matrix components is the basis for accurate and reproducible results. In addition, the maintenance demand of the chromatographic systems should be reduced to a minimum.</strong></p>
<p>In this presentation, sample preparation tools based on zirconia-silica adsorbents for the QuEChERS methodology as well as in form of solid phase extraction (SPE) cartridges will be introduced. Their applicability and improved fat and pigment removal will be demonstrated for pesticide analysis in samples like avocado and spices, as well as for polycyclic aromatic hydrocarbons (PAHs) in edible oils. A special QuEChERS mix for green samples (e.g. for spinach) containing zirconia-coated material in combination with a specialized carbon adsorbent ensures sufficient chlorophyll removal while maintaining recovery for planar pesticides.</p>
<p>Furthermore, solid phase microextration (SPME), an easy-to-automate sample preparation technique, using overcoated (OC) adsorbent fibers will be discussed with application examples. These allow efficient adsorptive extraction of semi-volatile compounds from complex matrices like food samples by direct immersion.</p>
<h3><strong>Attend this presentation to learn about:</strong></h3>
<ul>
<li>the use and mechanisms behind zirconia-coated silica adsorbents</li>
<li>choosing a suitable material/tool for sample cleanup</li>
<li>how direct immersion SPME can be used for adsorptive extraction of less volatile compounds from complex food samples, expanding the applicability of SPME</li>
</ul>
<blockquote>
<p><strong>Presenter: Klaus Buckendahl (Analytical Sciences Liaison, Advanced Analytical Europe, Merck KGaA, Darmstadt, Germany)</strong></p>
</blockquote>
<blockquote>
<p>Klaus Buckendahl received a degree in engineering from the FH Münster University of Applied Science in Germany, majoring in instrumental analysis. He started his career in the technical service at Sigma-Aldrich providing support for the Supelco® line of analytical products. Over the last 20+ years, he held various positions within the company including Product Specialist and Technical Marketing Manager for Sample Preparation in Europe, among others. Currently he works as an Analytical Science Liaison at Merck in the analytical chemistry business unit.</p>
</blockquote>


Pixabay/Jill Wellington:  Sample Preparation for Fatty and Complex Food Matrices

LCMS webináře se zaměřením na SPME - strana 1