Je mu třicet let, se špičkovým výzkumem začal před maturitou a jeho jméno nese asteroid. Robin Kryštůfek zkouší základní výzkum i prostředí biotechnologických firem. „Jsou to propojené světy,“ říká v podcastu CHEmic.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Podcast_CH_Emic_73_Existuji_mista_kde_stihnete_delat_vynikajici_vedu_cestou_na_obed_4d7e661cf9.jpg" alt="ÚOCHB/Tomáš Belloň – Podcast CHEmic #73 – Existují místa, kde stihnete dělat vynikající vědu cestou na oběd." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Podcast_CH_Emic_73_Existuji_mista_kde_stihnete_delat_vynikajici_vedu_cestou_na_obed_4d7e661cf9.jpg 218w," sizes="100vw" width="2000" height="1433"><blockquote>Podcast CHEmic představuje vědce a vědkyně z Ústavu organické chemie a biochemie AV ČR, jejich život v labech i mimo ně.</blockquote><blockquote>CHEmic najdete v podcastových aplikacích:</blockquote><blockquote><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/0ELIQTRkC3TFrVYnZgztsy?si=b4407e1f54824315&amp;nd=1">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/cz/podcast/podcast-chemic-1-riskovat-se-vyplat%C3%AD-ne%C3%BAsp%C4%9Bchu-se-nesm%C3%ADme/id1683797089?i=1000611870620">Apple Podcasts</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9kZmFhNjA4OC9wb2RjYXN0L3Jzcw">Podcasty Google</a></li></ul></blockquote><blockquote>a na našem <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/playlist?list=PLFJNDHHAxyMszoY-Hm4BGJ6nN7zNLZXO-">YouTube kanálu</a>.</blockquote>

Podcast CHEmic #73 – Existují místa, kde stihnete dělat vynikající vědu cestou na oběd

Plnění požadavků směrnice EU o pitné vodě: klíčová role přípravy vzorků při analýze stopových kontaminantů

Ačkoliv moderní zemědělství potřebuje vycházet z přesných dat o půdních, rostlinných i environmentálních podmínkách v reálném čase, cenově dostupná, dostatečně citlivá a zároveň robustní monitorovací zařízení pro tento účel v současné době chybí. Jako vhodné řešení se podle vědců nabízí nízkonákladové senzory založené na nových chytrých materiálech a technologiích tisku. Dosavadní výsledky multiioborového výzkumu i návrhy na vývoj těchto zařízení představili výzkumníci z Česka, Velké Británie, Španělska i USA v přehledovém článku v prestižním časopise <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1">Nature Communications</a>.„Senzorické technologie pro monitorování zdraví rostlin jsou stále v plenkách. Na trhu jsou běžné dostupné jen jednoduché senzory, které jsou schopné monitorovat pouze základní parametry jako například pH, vlhkost v půdě, případně teplotu. Pokud však mají zemědělci čelit současným výzvám včetně klimatických změn a zajistit pro lidstvo dostatek potravy, potřebují mnohem účinnější pomocníky, jež jim umožní monitorovat například i různé patogeny včetně bakterií či plísní. Podle nás je vhodným řešením kombinace nových chytrých materiálů a tisku pro produkci levných, odolných a škálovatelných materiálů,“ uvedl první autor článku David Panáček z CATRIN, který na studii pracoval během své stáže v Imperial College London.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152">Senzory pro monitorování zdraví rostlin například v porovnání s podobnými zařízeními pro humánní medicínu pokulhávají. Klíčovou roli v možném posunu hraje podle autorů pokrok v materiálových vědách, jenž vývoj škálovatelných senzorových technologií umožní. „Tiskové techniky včetně inkoustového tisku, sítotisku, aerosolového tisku, 3D tisku a přímého laserového zápisu nabízejí flexibilní cesty k výrobě ohebných senzorů, senzorů pro velké plochy i senzorů integrovaných přímo do rostlin. Přehledový článek shrnuje nedávný pokrok v oblasti tisknutelných nízkorozměrných materiálů pro zemědělské senzory, analyzuje jejich fyzikálně-chemické vlastnosti ve vztahu k senzorovému výkonu a diskutuje hlavní výzvy a budoucí příležitosti vyžadující mezioborovou integraci,“ uvedl jeden z korespondujících autorů Michal Otyepka.Výzkum propojil materiálové vědce, chemiky, biology, odborníky na senzing i technologie tisku. Materiálový výzkum a využití chytrých materiálů na bázi grafenu zaštítili vědci CATRIN Univerzity Palackého a VŠB-Technické univerzity Ostrava, znalostmi o vývoji rostlin, jejich reakcích na stresové podmínky i monitorování jejich vlastností přispěli rostlinní biologové z CATRIN, o oblast elektroniky se postarali výzkumníci z Imperial College London, technologiím tisku se věnovali zástupci <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/36">CEITEC – VUT</a>. V týmu nechyběli ani přední odborníci na senzing z Katalánského institutu nanověd a nanotechnologií v Barceloně a svými bohatými znalostmi přispěl i „otec senzingu a elektrochemie“ Joseph Wang z University of California San Diego.„Jedná se o průlomovou studii na toto téma, k níž se podařilo přizvat skutečně velká jména v daných oborech. V neposlední řadě studie dokládá to, že interdisciplinarita v CATRIN dává vzniknout zcela novým a perspektivním výzkumným tématům, jako je rostlinný senzing a jeho využití pro studium interakce rostlin s prostředím a chytrém zemědělství,“ doplnila další z korespondenčních autorů Nuria De Diego. &nbsp;

Současné senzory nestačí. Vědci navrhují novou cestu ke sledování zdraví rostlin

Osobnosti

Životní prostředí

Vědecký článek

Popularizace

Věda a výzkum

Video

Článek

ÚOCHB AV ČR je přední mezinárodně uznávaná vědecká instituce, jejímž hlavním posláním je základní výzkum v oblasti chemické biologie a medicinální chemie, organické a materiálové chemie, chemie přírodních látek, biochemie a molekulární biologie, fyzikální chemie, teoretické chemie a analytické chemie.

Ústav organické chemie a biochemie AV ČR

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Společnost Organomation, založená v roce 1959, navrhuje a vyrábí vysoce kvalitní dusíkové koncentrátory a extrakční systémy. Jejich laboratorní přístroje, známé svou inovativností a odolností, se používají po celém světě pro efektivní přípravu vzorků a jsou doprovázeny silnou zákaznickou podporou.

Organomation

Metrohm

Agilent Technologies

Technology Networks

SelectScience

SCIEX

Waters Corporation

Join us for an exclusive two-day event where Agilent will showcase cutting-edge biopharma solutions.
The first day of the event we will explore Agilent’s comprehensive portfolio for the spectrum of applications from drug discovery to quality control. Learn more about our cell analysis and genomics expertise and the tools we provide to drive IVT mRNA development, protein therapeutics and cell and gene therapies
The second day will focus on advanced analytical solutions, including HRMS for tRNA sequencing and LC/MS for DNA/RNA analysis. Learn how to scale up oligonucleotide purification with Agilent biocolumns, which enhance the efficiency and accuracy of your processes.
By attending this event you will:
<ul>
<li>Gain insights from Agilent to optimize biotherapeutic workflows, including rigorous quality testing in cGMP environments and handling nucleic acid, vaccines, mAB and protein samples.
</li>
<li>Understand how metabolic analyses can impact CAR cell function and behavior, using cytolytic cell killing assays on the xCELLigence system to develop cell therapy processes and confirm product potency.
</li>
<li>Learn about new techniques in high-resolution LC/MS for analyzing tRNA modifications.
</li>
<li>Discover software tools available for high-resolution MS systems in both research and QA/QC labs.
</li>
<li>Compare analytical and semipreparative LC purification methods for synthetic oligonucleotides, gaining competitive insights into purification strategies.
</li>
</ul>
<h5>Talk 1: Advanced Analytical Solutions for Nucleic Acid Analysis and Purification</h5>
<ul>
<li>Presented by Dr. Charlotte Lekieffre, Biopharma Application Specialist, Agilent Technologies</li>
</ul>
The emphasis during the second day of the Summit will be on advanced analytical solutions, such as HRMS for tRNA sequencing and LC/MS for DNA/RNA analysis. Additionally, you’ll discover techniques to enhance the efficiency and accuracy of your processes by scaling up oligonucleotide purification using Agilent biocolumns. 
<h5>Talk 2: Extracted Yeast tRNA Sequencing by LC-MS/MS</h5>
<ul>
<li>Presented by Aurore Attina, Engineer of Mass Spectrometry, University of Montpellier</li>
</ul>
RNA modifications are essential for RNA stability, maturation, and functionality; directly influencing protein translation and gene regulation. They play a central role in various biological processes and are associated with many diseases, including cancers and neurological disorders. tRNA (transfer RNA), which plays a key role in protein synthesis, is the most modified molecule in the organism known to date. tRNA modifications are essential to ensure their correct function in protein translation, maintain the accuracy and fidelity of the genetic code, and enable flexible adaptation to changing cellular conditions and are therefore a crucial attribute to monitor. To monitor and map these modifications of tRNA, we have developed a LC-HRMS analytical workflow, first using synthetic oligonucleotide for the method optimization. In this webinar, we will first go through the various steps involved in LC-MS/MS method optimization using synthetic oligonucleotides. In a second part, we will present the protocol development of an enzymatic digestion applied to tRNA extracted from yeast. This digestion generates oligonucleotide fragments that can be analyzed by LC-MS/MS for sequence confirmation.
<h5>Talk 3: Discover Agilent’s Software Tools to Confirm Oligonucleotide Sequence Integrity</h5>
<ul>
<li>Presented by Dr. Holger Stalz, LC/MS Product Specialist Austria &amp; Switzerland, Agilent Technologies</li>
</ul>
Mass spectrometry (MS) is increasingly important for the development of therapeutic modalities such as oligonucleotides. A common analytical method for large molecules is intact mass by LC/MS. This can be used for the characterization and identification of a product or process-related impurities, or simply as a confirmation of molecular weight. The newly introduced Agilent OpenLab CDS 2.8 SW version comes with a set of features to enable the automatization of biopharma workflows. If you want to know how LC/MSD Spectral Deconvolution of your biopharma samples can be automated, we will provide answers during our presentation. Even more details on Oligonucleotide sequence confirmation and impurities characterization can be acquired using the power of a high-resolution accurate mass system (HRAM) on the Agilent 6545XT AdvanceBio LC/Q-TOF. Analyzing the sample data with the software workflows in Agilent BioConfirm version 12 will support the user to get the trusted answers to their most relevant questions.
<h5>Talk 4 Maximize Your Resources and Simplify Scale-up with AdvanceBio Oligonucleotide Columns</h5>
<ul>
<li>Presented by Dr. Andrea Tripodi, Application Development Engineer, Agilent Technologies</li>
</ul>
Several classes of nucleic acids, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and aptamers are being investigated for potential therapeutic applications. Synthetic oligonucleotides inevitably contain many impurities due to limitations in the efficiency of each chemical reaction used during manufacture. They include deletion sequences (missing one or more nucleotides) and reaction by-products often arising during the final deprotection or cleavage steps. Ion pair reversed-phase (IP-RP) chromatography stands out as the prevalent method for analyzing and purifying oligonucleotides. For increased resolution and separation of your full-length synthetic oligonucleotide from closely related impurities, AdvanceBio Oligonucleotide is the ideal choice. The latest developments include semi-preparative, and lab-scale preparative columns packed with superficially porous particles that provide excellent performance and resolution without compromising column loading. A fast and easy scale-up method from analytical to semi-preparative scale was successfully achieved using a 10 mm ID column enabling higher sample loading using the same analytical LC instrument.

Technology Networks: Biopharma Innovations Summit

Biopharma Innovations Summit Day 2

Learn more about our cell analysis and genomics expertise and the tools we provide to drive IVT mRNA development.

This seminar will guide you through troubleshooting HPLC systems and chromatographic issues using a structured workflow.We will share a novel approach to emphasize the importance of system monitoring, as troubleshooting without monitoring is considerably more challenging. After introducing some key concepts and a troubleshooting workflow, we'll explore practical examples by applying the workflow to failed chromatograms to identify the cause of failure and then use a test cycle to confirm the fix.Who should attend: Analysts working in regulated environments (eg. GLP, GMP) or in non-regulated environments (eg. R&amp;D) who want to troubleshoot their HPLC systems and chromatographic problems effectively.<h4>Key Learnings:</h4>1. The importance of routine system monitoring2. Using qualification checks to diagnose a failure3. Understanding Failure Indicators (HOW the chromatogram failed) vs. Failure Causes (WHY the chromatogram failed)4. Using troubleshooting workflows to quickly identify the failure cause<blockquote>Presenter: Maureen DeLoffi (Senior Product Manager, Waters COrporation)Maureen DeLoffi is a Senior Product Manager at Waters Corporation, where she manages the small molecule portfolio of Analytical HPLC columns. Prior to her Product Manager role, she spent over 12 years as a scientist in the Column Technology Development Lab at Waters. She holds a bachelor’s degree in Mechanical Engineering from the University of New Hampshire.</blockquote>

Waters Corporation: HPLC Troubleshooting: A System Monitoring Approach

HPLC Troubleshooting: A System Monitoring Approach

Troubleshooting HPLC systems and chromatographic issues using a structured workflow.

Ion chromatography (IC) hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) – IC-ICP-MS is the preferred solution for speciation analyses of trace elements such as chromium, arsenic, selenium, or mercury.In this webinar we focus on some key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS. Based on practical examples such as chromium speciation according to ISO 24384, we demonstrate the benefits of bi-directional communication, real-time status updates, and a single, consolidated sample list streamlining your trace elemental analysis with a single-software solution.<h4>Key learnings of this webinar:</h4><ul><li>Learn why IC is the method of choice for the separation of ionic components for subsequent quantification with ICP-MS</li><li>Explore the features that make Agilent ICP-MS a superior choice for speciation analysis</li><li>Understand the streamlined workflow for chromium speciation according to ISO 24384 using MassHunter ICP-MS</li><li>Understand the added value of inline sample preparation techniques available with Metrohm IC</li></ul><h4>Who should attend?</h4><ul><li>Laboratory managers, analytical chemists, researchers doing trace elemental analysis</li></ul><blockquote>Presenter: Dr. Elke Süss (Application Specialist Ion Chromatography, Metrohm International Headquarters)Elke Süss received a M.Sc. in Geoecology and a Ph.D. in Environmental Geochemistry in 2011 from Bayreuth University, Germany. After a position as laboratory manager at Bayreuth University, she worked as a Research Assistant and then PostDoc at ETH Zürich and Eawag focusing on trace elemental speciation and has more than 10 years of experience with IC-ICP-MS in this field. In 2018, she joined the Ion Chromatography team at Metrohm International Headquarters in Switzerland as an Application Specialist. &nbsp;Presenter:&nbsp;Andrew Brotherhood (Atomic Spectroscopy Application Engineer, Agilent UK)Andrew has over 15 years’ hands-on experience with ICP-MS, ICP-OES and Ion chromatography instrumentation. He has mainly worked in the pharmaceutical analysis industry gaining significant experience with developing and validating methods to pharma regulations.Andrew started working for Agilent as a full-time employee in January 2018 working as an Atomic Spectroscopy Application Engineer based at the Agilent Centre of Excellence in the UK.</blockquote>

Metrohm: Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS.

Metrohm ion chromatography meets Agilent ICP-MS

Day one: Innovation and data insights<ul><li>Discover how to achieve high sensitivity, speed, and resilience when working with large, complex sample sets</li><li>Learn strategies to speed up your covalent protein drug discovery</li><li>Gain insights into accelerating the development of multiple modalities</li><li>Understand the latest advancements in quantitative proteomics with ZT Scan DIA</li><li>Overcome limitations with cutting-edge artificial intelligence quantitation software</li></ul>Agenda-at-a-glanceWelcome and introduction to innovation and data insights&nbsp;&nbsp;&nbsp;&nbsp;Advancing robustness and serviceability of a high-end triple quad mass spectrometer in a high-throughput bioanalytical lab<ul><li>Highly sensitive mass spectrometers allow the advanced bioanalytical labs of today to achieve the LOQ required of potent biologic drugs and provide maximum flexibility in choice of sample prep techniques. However robust mass spectrometers are crucial for several reasons:<ul><li>Aid in ensuring the consistent quantitative performance of an assay</li><li>Effectively allow a lab to meet their project timelines</li><li>Are essential for handling the inherent variability of analyzing diverse molecules and diverse samples required for bioanalysis</li></ul></li></ul>The new fast in drug discovery: a new MS system to study covalent protein drugs<ul><li>The combination of a super-fast sampling interface with the highly sensitive ZenoTOF 7600 system makes it an ideal system for evaluating covalent binding screens. Main findings in our experiments using the Echo® MS+ system:<ul><li>Speed: measurements from a full 384-well plate in 15 min or 1536-well plate in less than one hour</li><li>Precision: low injection volume supports repetitive measurements and time series; capture full kinetic data set in one experiment</li><li>Quality: high data quality allows for full automated processing, delivering immediate hitlist output</li></ul></li></ul>icIEF-UV/MS characterization of charge Isoforms for biotherapeutic products<ul><li>Characterization of icIEF charge isoforms, whether in early product development or associated with licensure filings, is usually achieved through ion exchange (IEX) liquid chromatography coupled with mass spectrometry. icIEF-MS technology has recently emerged to enable the direct characterization of specific species in the icIEF electropherogram, eliminating the need for extensive method development.<ul><li>Discover opportunities to advance core platform technologies with novel characterization approaches</li><li>Hear case studies on understanding molecular structure information</li><li>New approaches to characterizing post-translational modifications of charge isoforms</li></ul></li></ul>Expanding qualitative and quantitative sensitivity for immunopeptidomics using ZT Scan DIA<ul><li>Learn how utilizing a research-grade Zeno-trap time-of-flight LC-MS system can advance current applications in immunopeptidomics and proteomics, including:<ul><li>What is ZT Scan DIA, the technology and how it benefits data acquisition</li><li>Preliminary proteomics and immunopeptidomics results using ZT Scan DIA</li><li>Future applications of immunopeptidomics using ZT Scan DIA</li></ul></li></ul>Artificial intelligence quantitation (AI quant): molecular structure and mass spectral data quality driven processing of high-resolution mass spectrometry for quantitative analysi<ul><li>High-resolution mass spectrometry (HRMS) has long sought to be a viable alternative for quantitative workflows but has been unable to broadly compete, mainly due to the lack of suitable data processing software. In this work we describe:<ul><li>A molecular structure-dependent workflow</li><li>The holistic and user-independent processesing of HRMS data</li><li>The automatic quantification of small drug-like molecules</li></ul></li></ul>Q&amp;A roundtable: innovation and data insights with the experts<ul><li>Moderated by: Jamie Wighton, Senior Director LC-MS Research, SCIEX</li><li>Panelists include:<ul><li>Rathna Veeramachaneni, Director, Biopharma LC-MS/MS, KCAS Bio</li><li>Xiaping He, Senior Scientist, Pfizer</li><li>Markus Stöckli, Senior Principal Scientist, Novartis Institutes for BioMedical Research</li><li>Tony Purcell, Professor, Monash University&nbsp;</li><li>Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert</li></ul></li></ul><blockquote>Moderator: Jamie Wighton (Senior Director LC-MS Research, SCIEX)Jamie joined SCIEX 20 years ago and has held multiple technical and leadership roles throughout his career at SCIEX. &nbsp;Starting out as an engineer in manufacturing operations, Jamie has since led teams in supply chain, product development, and most recently the research and product applications teams within R&amp;D. Prior to joining SCIEX, Jamie worked at JDS Uniphase as an optical test engineer.Jamie holds a B.Sc. in engineering physics from Queen’s University.Presenter: Rathna Veeramachaneni (Director, Biopharma LC-MS/MS, KCAS Bioanalytical)Presenter: Markus Stöckli, Senior Principal Scientist, Novartis Institutes for BioMedical ResearchPresenter: Xiaoping He, Senior Scientst, PfizerPresenter: Tony Purcell, Professor, Monash UniversityPresenter: Kevin Bateman, Retired Pharmacokinetics, Pharmacodynamics and Drug Metabolism Expert</blockquote>

SCIEX summit Day one: Innovation and data insights

Importance of LC-MS in food and environmental testing, pharmaceutical and biopharmaceutical discovery and development and biomedical and omics research.

UV-Vis spectroscopy is a cornerstone analytical technique in the pharmaceutical industry, widely employed for its versatility and reliability serving essential functions such as the synthesis of drug compounds, purity assessment, dissolution profiling, and the analysis of biomolecules throughout the drug development process. This technique is pivotal for ensuring the quality and efficacy of pharmaceutical products. However, the pharmaceutical industry faces several challenges with traditional UV-Vis spectroscopy, such as the need for stringent regulatory compliance, the demand for high precision and accuracy, and the requirement for efficient data management systems to handle the vast amount of data generated.The Agilent Cary 3500 UV-Vis model addresses these pain points effectively, join the webinar to discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.Key Takeaways:<ul><li>Innovative Temperature Control: Learn how the Cary 3500’s precise temperature control accelerates your analytical processes.</li><li>Rapid Data Acquisition: Understand the impact of high-speed data collection on your research outcomes.</li><li>Small-Volume Mastery: Explore the instrument’s proficiency in small-volume analysis, ensuring accuracy down to the minutest quantities.</li><li>Highest Absorbance Range: Explore the Cary 3500’s superior absorbance range for unparalleled sensitivity in your measurements.</li><li>OpenLab Server Connectivity: Experience the seamless data management and integrity that OpenLab server-based connectivity provides, meeting stringent regulatory compliance.</li><li>Interactive Q&amp;A Session: Engage with our experts to address your queries and discuss the instrument’s application in real-world pharmaceutical scenarios.</li></ul><blockquote>Presenter: Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies)Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</blockquote>

Agilent: Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.

Cary 3500 UV-VIS Advanced Capabilities

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #5: General Sample Preparation | F&amp;E Summer School - Day 2 - Module 1</h3>Sample preparation is a key aspect in the analytical workflow and heavily determines the quality of the analysis. Solid Phase Extraction is a fundamental sample preparation technique widely used across all areas of analytical chemistry. Whether new to SPE or seeking a refresher, this webinar will introduce the basics of sample preparation and provide practical insights and technical background on the benefits when choosing SPE over another form of sample preparation, especially for analytes in complex matrices, such as the ones often encountered in Food and Environmental analysis. Join us in exploring SPE key parameters and best practices for implementing successful SPE methods. The session will combine PowerPoint slides with videos describing good practices and showing a practical example on the complex analysis of PFAS.Our guest speaker Chiara Sarti from Cranfield University, Bedford UK, will share her research results on the work with new dual layer cartridges to extract PFAS from different environmental samples.<h5>What you'll learn:</h5><ul><li>Understanding SPE fundamentals</li><li>Making SPE simple with water-wettable sorbents</li><li>Verifying successful SPE implementation</li></ul><blockquote>Presenter:&nbsp;Xavier Rodríguez (Business Development Manager Chemistry Group, Southern Europe, Waters)Xavier is part of the European Market Development Team. He works as an Application Specialist with focus on sample prep and has more than 20 years of experience in solving sample prep challenges.Presenter:&nbsp;Chiara Sarti (Ph.D. Student, Department of Chemistry "Ugo Schiff", University of Florence)</blockquote>

Waters Corporation: The Waters 2024 Virtual Summer School

General Sample Preparation

Join us in exploring SPE key parameters and best practices for implementing successful SPE methods. 

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #6: Automated Sample Preparation | F&amp;E Summer School - Day 2 - Module 2</h3>This Module builds on the previous one by adding automation to the sample preparation methods. The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders called Dominos for a full walk-away automation solution.Creating the connected laboratory, Andrew+ is part of the OneLab™ ecosystem, executing laboratory protocols designed in OneLab software. This flexible architecture enables you to effortlessly transition from laborious manual pipetting procedures to error-free, fully-robotized lab workflows – without any knowledge of programming, laboratory robotics or automation engineering. and explains processes the Andrew+ pipetting robot can take over in your lab.The European Union has adopted Commission Recommendation (EU) 2022/1431 to monitor PFAS in fruits, vegetables, milk and baby food. To achieve quantification at lowest levels of PFAS in food matrices, sample preparation is required which comprise of many pipetting steps and can be time-consuming and error prone. We will demonstrate an automate workflow for the analysis of PFAS in milk using a pipetting robot and stacked dual-phase SPE cartridges to meet EU 2022/1431 levels.<h5>What you'll learn:</h5>Possibilities to automat liquid handling processes in LC and LC-MS e.g.<ul><li>Serial dilution</li><li>Calibration curve</li><li>Solid Phase Extraction (SPE)</li></ul><blockquote>Presenter:&nbsp;Xavier Rodríguez (Business Development Manager Chemistry Group, Southern Europe, Waters)Xavier is part of the European Market Development Team. He works as an Application Specialist with focus on sample prep and has more than 20 years of experience in solving sample prep challenges.Presenter:&nbsp;Daniel Ng PhD (Principal Scientist, Waters Corporation)Daniel Ng received his PhD from the University of Manchester in mass spectrometry proteomics. He worked for 5 years at the Waters mass spectrometry headquarters in Wilmslow, UK, as a service support development engineer specializing in mass spectrometry instrumentation. In 2019, he took up a new role as a principal scientist at the International Food and Water Research Centre (Waters) in Singapore focusing on using advanced instrumentation to answer analytical challenges in the food and water industry. Since 2023, Daniel has lead the Food, Environmental and Material Science Analytical Professional Service team in the Asia-Pacific Region, developing analytical solutions to meet key challenges that customers face.</blockquote>

Automated Sample Preparation

The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders.

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #7: Quantification for Targeted Analysis | F&amp;E Summer School - Day 2 - Module 3</h3>MS Quan is an application in the waters_connect™ for Quantitation software platform that is designed to streamline the LC-MS/MS data processing and review with innovative workflows, data visualization and data navigation. The MS Quan application’s main workflows and overarching features such as task-oriented workflow, batch-level review, and exception-focused review are introduced and illustrated with a PFAS analysis dataset.<h5>What you'll learn:</h5><ul><li>How to create processing method</li><li>Data review with exception focus review</li><li>Compare data and evaluate peak integration</li><li>Export and report of final results</li></ul><blockquote>Presenter:&nbsp;Helge Grunwald (Sr Sales Applications Chemist, Waters Corporation)Helge is part of the Customer Success team at Waters with a focus on LC-MS/MS application and sales support. He works in this role for more than 4 years and gained experience in previous roles as project manager at Intertek and method developer at Basilea Pharmaceutica after he finished his Master of Science in Life Science at FH Nordwestschweiz.</blockquote>

Quantification for Targeted Analysis

The MS Quan application’s main workflows and overarching features are introduced and illustrated with a PFAS analysis dataset. 

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #8: Instruments &amp; Software for Non-Target Screening | F&amp;E Summer School - Day 2 - Module 4</h3>This session will focus on presenting in detail the data evaluation of HRMS-Screening experiments. Firstly, we will explain the data-independent acquisition modes MSE and HDMSE. We will describe an intelligent and efficient peak detection algorithm of the HRMS data. The waters_connect software supports us with several tools for the challenging non-Target screening. We will present a selection of discovery tools which collect additional information about the unknown masses to reduce the number of potential candidates. This includes a binary comparison to find differences between samples or the get information on common fragments etc. In addition, multivariate statistics can also be used as a powerful tool for identifying significant non-Target masses. Finally, the determination of the molecular formula of potential candidates and a possible search in online libraries will be presented.<h5>What you'll learn:</h5><ul><li>Data acquisition in depth (MSE, CCS)</li><li>waters_connect Software &amp; Intelligent Peak Detection</li><li>UNIFI App and Workflow</li><li>Binary Compare - find the Differences</li><li>Discovery Tools – Common Fragments, Mass defect filtering, Halogen Match and more</li><li>Multivariate statistics</li><li>Pattern Targeting Application</li></ul><blockquote>Presenter:&nbsp;Christoph Thomas (Principal Sales Applications Chemist, Waters Corporation)Christoph Thomas is a Principal Sales Applications Chemist from the Central Europe Customer Success Team based in Eschborn, Germany. He has more than 25 years’ experience in the field of Chromatography and Mass Spectrometry and is familiar with several application areas using Quadrupole and Tof instruments. Within the last decade his projects were mainly focused on the waters_connect Screening Solution in food and environmental screening, toxicology screening, metabolite identification and in the field of extractables and leacheables.Presenter:&nbsp;Gunnar Weibchen (Principal MS Sales Dev Specialist, Waters Corporation)Gunnar studied Chemistry and obtained a PhD in Organic and Analytical Chemistry in Hamburg. After working as an Application Chemist in the demo laboratory at Varian, has been with Waters in Sales and Marketing since 2010</blockquote>

Software and Instruments for NTS

This session will focus on presenting in detail the data evaluation of HRMS-Screening experiments. 

Join this webinar to discover how HPTLC can enhance the reliability and efficiency of your edible oil quality assessments.Dr. Tiên Do, Chief Scientific Officer at CAMAG, and Paul Rogeboz, Junior Research Assistant at Nestlé Research will discuss how a newly developed HPTLC method was developed to identify edible oils. Find out how it was used to detect adulteration with remarkable accuracy.Our experts will also explore the statistical validation of the method, its robust performance in interlaboratory studies, and its ability to identify adulteration levels from 5% to 25%.<h4>Key topics discussed in this webinar will include:</h4><ul><li>Understanding HPTLC for oil authenticity: Gain insights into the principles and applications of high-performance thin-layer chromatography (HPTLC) in ensuring edible oil authenticity</li><li>Method development and validation: Learn about the development of the untargeted fingerprint profiling method for detecting vegetable oil adulteration and the statistical validation processes for variability, detection limits, and reproducibility</li><li>Real-world application and robustness: Discover the robustness of the HPTLC method through interlaboratory studies and understand its practical applications in the food industry</li><li>Detection capabilities: Explore the method's ability to accurately detect adulteration levels ranging from 5% to 25%</li></ul><h4>Who should attend?</h4><ul><li>Quality control professionals</li><li>Food industry researchers</li><li>Regulatory affairs specialists</li><li>R&amp;D teams</li><li>Food manufacturers</li><li>Lab technicians</li></ul><blockquote>Presenter: Dr. Tiên Do (Chief Scientific Officer, CAMAG)Dr. Tiên Do joined CAMAG in 2014 and became the Chief Scientific Officer in January 2024. In this role, she crafts and implements the organization's scientific vision, spearheading research and development efforts to propel scientific objectives forward. Additionally, she cultivates partnerships with academic and industry leaders to drive innovative collaborations. Prior to her current role, Dr. Do served as Head of Laboratory and Deputy Head of Laboratory.Presenter:&nbsp;Paul Rogeboz MSc (Junior Research Assistant, Nestlé Research)Paul Rogeboz works at Nestlé Research in Switzerland as a Junior Research Assistant, specializing in HPTLC applications in the food safety field. In his role, he contributes to scientific application projects by developing novel effect-based toxicological analyses using HPTLC for decision-making. He is also involved in the qualification and implementation of HPTLC methodologies for the assessment of food matrices adulteration.Presenter:&nbsp;Carrie Haslam (Associate Editor, SelectScience)</blockquote>

SelectScience: Development of an HPTLC method for evaluating vegetable oil adulteration

Development of an HPTLC method for evaluating vegetable oil adulteration

How HPTLC can enhance the reliability and efficiency of your edible oil quality assessments.