Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier | LabRulez LCMS
 

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ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIERCatalin Doneanu1, Christopher Knowles2, Jonathan Fox2, Emma Harry2, Ying Qing Yu1, Joseph Fredette1, Ann Grey1 and Weibin Chen11Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, UK;METHODSOVERVIEWRESULTSUV Peak Area[M-10H]-10Here we...
Klíčová slova
oligonucleotide, oligonucleotidepremier, premierost, ostbioaccord, bioaccordoligonucleotides, oligonucleotidesauu, auuutt, uttcca, ccaimpurity, impurityfluidic, fluidichps, hpstherapeutics, therapeuticsregular, regularblank, blankagu
UHPLC-TOFANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON AN UHPLCTOF MS SYSTEM WITH A MODIFIED SURFACE TECHNOLOGY122211C t li DCatalinCh i t ph KnowlesKl , JonathanJth FoxF , EmmaEH y , YingYi g QingQi g YuY , JosephJFredetted tt andd WeibinW ibi ChenChDoneanu...
Klíčová slova
oligonucleotide, oligonucleotidetid, tidlig, ligoff, offpremier, premieriti, itimer, merthi, thiimpurities, impuritiesith, ithacquity, acquityfigure, figurebioaccord, bioaccordfluidic, fluidicsurfaces
Application NoteHILIC as an Alternative Separation Mode forIntact Mass Confirmation of Oligonucleotideson the BioAccord SystemCatalin E. Doneanu, Ying Qing Yu, Joseph Fredette, William J. Warren, Weibin ChenWaters CorporationAbstractHILIC chromatography provides a clean, cost-effective separation method that can be easily incorporated...
Klíčová slova
oligonucleotides, oligonucleotidesbioaccord, bioaccordhilic, hilicintact, intactconfirmation, confirmationalternative, alternativeseparation, separationmass, massmode, modeoligonucleotide, oligonucleotidesystem, systemost, ostamide, amidesurfaces, surfacescharge
Application NoteLC-MS Analysis of siRNA, Single Guide RNAand Impurities Using the BioAccord™ Systemwith ACQUITY™ Premier and New AutomatedINTACT Mass ApplicationCatalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing YuWaters CorporationAbstractThis application note demonstrates...
Klíčová slova
intact, intactautomated, automatednew, newmass, massoligonucleotides, oligonucleotidesapplication, applicationbioaccord, bioaccordpremier, premieroligonucleotide, oligonucleotideaaa, aaaimpurities, impuritiessgrna, sgrnacaa, caasirna, sirnaacquity
 

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ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIERCatalin Doneanu1, Christopher Knowles2, Jonathan Fox2, Emma Harry2, Ying Qing Yu1, Joseph Fredette1, Ann Grey1 and Weibin Chen11Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, UK;METHODSOVERVIEWRESULTSUV Peak Area[M-10H]-10Here we...
Klíčová slova
oligonucleotide, oligonucleotidepremier, premierost, ostbioaccord, bioaccordoligonucleotides, oligonucleotidesauu, auuutt, uttcca, ccaimpurity, impurityfluidic, fluidichps, hpstherapeutics, therapeuticsregular, regularblank, blankagu
UHPLC-TOFANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON AN UHPLCTOF MS SYSTEM WITH A MODIFIED SURFACE TECHNOLOGY122211C t li DCatalinCh i t ph KnowlesKl , JonathanJth FoxF , EmmaEH y , YingYi g QingQi g YuY , JosephJFredetted tt andd WeibinW ibi ChenChDoneanu...
Klíčová slova
oligonucleotide, oligonucleotidetid, tidlig, ligoff, offpremier, premieriti, itimer, merthi, thiimpurities, impuritiesith, ithacquity, acquityfigure, figurebioaccord, bioaccordfluidic, fluidicsurfaces
Application NoteHILIC as an Alternative Separation Mode forIntact Mass Confirmation of Oligonucleotideson the BioAccord SystemCatalin E. Doneanu, Ying Qing Yu, Joseph Fredette, William J. Warren, Weibin ChenWaters CorporationAbstractHILIC chromatography provides a clean, cost-effective separation method that can be easily incorporated...
Klíčová slova
oligonucleotides, oligonucleotidesbioaccord, bioaccordhilic, hilicintact, intactconfirmation, confirmationalternative, alternativeseparation, separationmass, massmode, modeoligonucleotide, oligonucleotidesystem, systemost, ostamide, amidesurfaces, surfacescharge
Application NoteLC-MS Analysis of siRNA, Single Guide RNAand Impurities Using the BioAccord™ Systemwith ACQUITY™ Premier and New AutomatedINTACT Mass ApplicationCatalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing YuWaters CorporationAbstractThis application note demonstrates...
Klíčová slova
intact, intactautomated, automatednew, newmass, massoligonucleotides, oligonucleotidesapplication, applicationbioaccord, bioaccordpremier, premieroligonucleotide, oligonucleotideaaa, aaaimpurities, impuritiessgrna, sgrnacaa, caasirna, sirnaacquity
 

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