Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY PremierAplikace | 2021 | WatersInstrumentaceLC/TOF, LC/HRMS, LC/MSZaměřeníFarmaceutická analýzaVýrobceWatersKlíčová slovaoligonucleotide, bioaccord, premier, acquity, impurities, system, analysis, ost, oligonucleotides, confirmation, preceding, intact, impurity, fluidic, hps, extensively, pairing, traces, andorblue, interactpremier, maxpeakthe, ostsurfaces, phosphateperformed, redperformance, wyndham, surfaces, implemented, family, picomole, metal, technology, modified, ready, path, mass, conventional, reversed, surface, significantly, belongs, bsm, uplc, column, workflow, esi, triethylamine, emerged, barrier, mitigate, backbone
Podobná PDF
ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIER
2021|Waters|Postery
ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIERCatalin Doneanu1, Christopher Knowles2, Jonathan Fox2, Emma Harry2, Ying Qing Yu1, Joseph Fredette1, Ann Grey1 and Weibin Chen11Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, UK;METHODSOVERVIEWRESULTSUV Peak Area[M-10H]-10Here we...
Klíčová slova
oligonucleotide, oligonucleotidepremier, premierost, ostbioaccord, bioaccordoligonucleotides, oligonucleotidesauu, auuutt, uttcca, ccaimpurity, impurityfluidic, fluidichps, hpstherapeutics, therapeuticsregular, regularblank, blankagu
ASMS 2021: ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON AN UHPLC-TOF MS SYSTEM WITH A MODIFIED SURFACE TECHNOLOGY
2021|Waters|Postery
UHPLC-TOFANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON AN UHPLCTOF MS SYSTEM WITH A MODIFIED SURFACE TECHNOLOGY122211C t li DCatalinCh i t ph KnowlesKl , JonathanJth FoxF , EmmaEH y , YingYi g QingQi g YuY , JosephJFredetted tt andd WeibinW ibi ChenChDoneanu...
Klíčová slova
oligonucleotide, oligonucleotidetid, tidlig, ligoff, offpremier, premieriti, itimer, merthi, thiimpurities, impuritiesith, ithacquity, acquityfigure, figurebioaccord, bioaccordfluidic, fluidicsurfaces
HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioAccord System
2021|Waters|Aplikace
Application NoteHILIC as an Alternative Separation Mode forIntact Mass Confirmation of Oligonucleotideson the BioAccord SystemCatalin E. Doneanu, Ying Qing Yu, Joseph Fredette, William J. Warren, Weibin ChenWaters CorporationAbstractHILIC chromatography provides a clean, cost-effective separation method that can be easily incorporated...
Klíčová slova
oligonucleotides, oligonucleotidesbioaccord, bioaccordhilic, hilicintact, intactconfirmation, confirmationalternative, alternativeseparation, separationmass, massmode, modeoligonucleotide, oligonucleotidesystem, systemost, ostamide, amidesurfaces, surfacescharge
LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application
2022|Waters|Aplikace
Application NoteLC-MS Analysis of siRNA, Single Guide RNAand Impurities Using the BioAccord™ Systemwith ACQUITY™ Premier and New AutomatedINTACT Mass ApplicationCatalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing YuWaters CorporationAbstractThis application note demonstrates...
Klíčová slova
intact, intactautomated, automatednew, newmass, massoligonucleotides, oligonucleotidesapplication, applicationbioaccord, bioaccordpremier, premieroligonucleotide, oligonucleotideaaa, aaaimpurities, impuritiessgrna, sgrnacaa, caasirna, sirnaacquity