LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application
Aplikace | 2022 | WatersInstrumentace
LC/TOF, LC/HRMS, LC/MS
ZaměřeníFarmaceutická analýza
VýrobceWaters
Klíčová slovaintact, automated, new, mass, oligonucleotides, application, bioaccord, premier, oligonucleotide, aaa, sgrna, impurities, caa, sirna, acquity, csh, confirmation, ugc, ideally, cgu, cua, cuu, guc, gug, guu, worflow, spectrum, sgrnas, ccg, aua, deconvolves, cgg, agu, uag, interspaced, deconvolution, agg, desulfurization, algorithm, shorter, bayesspray, system, silencing, suited, impurity, gaa, uau, mock, during, longer
Podobná PDF
TIDES: INTACT MASS - A VERSATILE SOFTWARE FOR RAPID MASS CONFIRMATION OF OLIGONUCLEOTIDES AND THEIR IMPURITIES
2022|Waters|Postery
INTACT MASS - A VERSATILE SOFTWARE FOR RAPID MASS CONFIRMATION OF OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Patrick Boyce2, Henry Shion1, Joe Fredette1, Scott Berger1, Heidi Gastall2 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow,…
Klíčová slova
oligonucleotides, oligonucleotidesbioaccord, bioaccordsgrna, sgrnacaa, caapremier, premiersirna, sirnaaaa, aaasynthetic, syntheticcsh, cshmass, massrna, rnaguide, guideoligonucleotide, oligonucleotideemploying, employingcgu
TIDES: AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES
2023|Waters|Postery
AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…
Klíčová slova
auu, auuutt, uttagu, agucca, ccaaag, aagacc, accgua, guaoligonucleotide, oligonucleotideoligonucleotides, oligonucleotidessequence, sequencebioaccordtm, bioaccordtmsynthetic, syntheticcoverage, coverageprecursor, precursoratdbio
CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column
2023|Waters|Aplikace
Application Note CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column Maissa M. Gaye, Chris Knowles, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract The high speed, low cost, and reduced need…
Klíčová slova
sgrna, sgrnacolumn, columnrna, rnadigestion, digestionbioaccord, bioaccordacquity, acquitycomponents, componentscrispr, crisprtermini, terminiuplc, uplcsequences, sequenceshfip, hfipmatching, matchingintact, intactoligo
PAMS: AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES
2022|Waters|Postery
AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…
Klíčová slova
oligonucleotide, oligonucleotidesequence, sequenceapp, appconfirm, confirmimpurities, impuritiesoligonucleotides, oligonucleotidesvolution, volutionworkflow, workflowauu, auuutt, uttaag, aagagu, agugua, guaintact, intactbioaccordtm