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Rapid Oligonucleotides QC with Automated High Resolution ESI-LCMS and BioPharma Compass

 

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Automated High-Throughput Oligo QC: From Automated Sample Preparation to MALDI Spectra Assessment Synthetic oligonucleotides find a variety of applications in molecular biology. Primers for instance are used for DNA sequencing and amplification. Mass spectrometry is a well-established technology for quality…
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maldi, maldicta, ctagac, gacprimers, primersanchorchip, anchorchipoligo, oligospectra, spectramass, masscgg, cggpreparation, preparationagg, agggct, gctoligonucleotide, oligonucleotidecag, cagtaa
Routine analysis of drug to antibody ratio and drug distribution with maXis II Antibody drug conjugates (ADC) are small molecule conjugated mAbs. These are rapidly emerging complex biological molecules in the biopharma space. Abstract Characterization of ADC’s includes intact mass…
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dar, daradc, adcbruker, brukermaxis, maxisdrug, drugantibody, antibodylinker, linkerconjugation, conjugationaverage, averagemab, mabglycoforms, glycoformsdenaturing, denaturingconjugated, conjugatedpotency, potencyinterchain
Application Note # LCMS-78 Automated Analysis of Protein Sequence Variants by LC-MS Under the Control of BioPharma Compass Abstract Here we describe an automated UPLC-MS based method for the analysis and quality confirmation of the intact mass for protein sequence…
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compass, compassalbumin, albuminbiopharma, biopharmavariants, variantsintact, intactprotein, proteinbruker, brukertraceably, traceablymass, masstable, tableacceptance, acceptanceprocessed, processedmicrotof, microtofhalf, halfautomated
Protein Clipping Variant Analysis of Vedolizumab using dedicated workflows in BioPharma Compass Proteolytic degradation of biopharmaceuticals during their life cycle can pose health risks and require dedicated analysis. Abstract In this work we used enzymatically introduced antibody truncation variants as…
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etd, etdvedolizumab, vedolizumabclipping, clippingspeb, spebintensity, intensitymaxis, maxissequence, sequencecleavage, cleavagehinge, hingecid, cidvariant, variantvariants, variantsmiddle, middlesequencing, sequencingdown
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