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Routine analysis of drug to antibody ratio and drug distribution with maXis II

 

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APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…
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chain, chainheavy, heavypeptide, peptideadc, adcmass, massintact, intactnative, nativesetting, settingmapping, mappingconjugation, conjugationdrug, drugemtansine, emtansinelinker, linkerantibody, antibodylysine
Integrated characterization of a lysine-linked antibody-drug conjugate by native intact mass analysis and peptide mapping performed on a hybrid quadrupole-Orbitrap mass spectrometer with high mass range Aaron O. Bailey 1, Stephane Houel 1, Eugen Damoc 2, Kai Scheffler 3, Jonathan…
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linker, linkerkvepk, kvepkpeptide, peptidenative, nativeintact, intactdrug, drugmcc, mccemtansine, emtansineadc, adcmass, massmapping, mappingtrastuzumab, trastuzumabantibody, antibodyspectra, spectraforms
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC Application Note Biologics & Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents…
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adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, masscounts, countsdrug, drugantibody, antibodysec, seclinker, linkerspectrum, spectrumdar, darcharge, chargeconjugates
[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…
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adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicconjugated, conjugatedconjugates, conjugatesscale, scalecharacterization, characterizationprotein, proteinuplc, uplcvion, vionconjugation
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