Automated Analysis of Protein Sequence Variants by LC-MS Under the Control of BioPharma Compass
Aplikace | 2012 | BrukerInstrumentace
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
ZaměřeníKlinická analýza
VýrobceWaters, Bruker
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Fully automated glycoform profiling and sequence validation of the NIST reference antibody
2017|Bruker|Aplikace
Fully automated glycoform profiling and sequence validation of the NIST reference antibody Abstract Two key elements assessed during the analysis of mAb biotherapeutics are the glycosylation profile and the primary sequence. Using the NIST antibody as a model, three complementary…
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Protein Clipping Variant Analysis of Vedolizumab using dedicated workflows in BioPharma Compass
2020|Bruker|Aplikace
Protein Clipping Variant Analysis of Vedolizumab using dedicated workflows in BioPharma Compass Proteolytic degradation of biopharmaceuticals during their life cycle can pose health risks and require dedicated analysis. Abstract In this work we used enzymatically introduced antibody truncation variants as…
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Rapid Oligonucleotides QC with Automated High Resolution ESI-LCMS and BioPharma Compass
2020|Bruker|Aplikace
Rapid Oligonucleotides QC with Automated High Resolution ESI-LCMS and BioPharma Compass Oligonucleotides – sequences of nucleotides (RNA and DNA) – are vital research tools that have a wide range of applications in genetic testing, research, and forensics. Abstract Common applications…
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Recombinant SARS-CoV-2 Receptor Binding Domain: Comprehensive Top-Down Sequence Confirmation, Curation and O-Glycosylation Site Determination
2021|Bruker|Aplikace
Recombinant SARS-CoV-2 Receptor Binding Domain: Comprehensive Top-Down Sequence Confirmation, Curation and O-Glycosylation Site Determination Know your SARS-CoV-2 antigen structure before it´s use in research and diagnostics Abstract The COVID pandemic dramatically influences our life and the demand remains very high…
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