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CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column

 

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Application Note LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application Catalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing…
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INTACT MASS - A VERSATILE SOFTWARE FOR RAPID MASS CONFIRMATION OF OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Patrick Boyce2, Henry Shion1, Joe Fredette1, Scott Berger1, Heidi Gastall2 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow,…
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Application Note Size-Exclusion Chromatography Method for Poly(A) Tail Analysis of mRNA Martin Gilar Waters Corporation Abstract The first in-class therapeutic messenger RNA (mRNA) vaccines were successfully developed against SARS-CoV2 virus. Therapeutic mRNA molecules can also be used for protein replacement…
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Oligonucleotide Analysis: Practical Techniques and Method Development Optimization for HPLC Mohit Patel LC Columns and Consumables Technical Support December 19, 2023 1 12/19/2023 DE # DE48216954 What Are Oligonucleotide Therapeutic Types? Oligonucleotides are being increasingly developed as therapeutics against a…
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