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Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF

 

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Poster Reprint ASMS 2023 Poster number ThP 566 Oligonucleotide Characterization by Bio LC and Q-TOF Yulan Bian1, David L Wong2 1Agilent Technologies, Inc., Singapore 2Agilent Technologies, Inc., Santa Clara, CA Introduction Experimental Sample preparation Oligonucleotide (RNA) Resolution Standard was obtained…
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oligonucleotide, oligonucleotidesequence, sequencetpi, tpioligonucleotides, oligonucleotidesconfirmation, confirmationimpurities, impuritiesworkflow, workflowmasshunter, masshunteravg, avglength, lengthadvancebio, advancebioapta, aptaoerg, oergagilent, agilentbio
Application Note BioPharma MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography Authors Guannan Li and Peter Rye Agilent Technologies, Inc. Introduction Oligonucleotides are commonly analyzed by liquid chromatography/mass spectrometry (LC/MS) in negative ion polarity mode using ion-pairing reversed‑phase (IP‑RP) methods.…
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charge, chargecounts, countsribose, riboseoligonucleotides, oligonucleotidesmass, masscollision, collisionhilic, hilicacquisition, acquisitionfragments, fragmentsoligo, oligosequence, sequencemultiple, multiplespectrum, spectrumoligonucleotide, oligonucleotideenergies
Application Note Biopharma/Pharma Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF Robust and sensitive sequence confirmation of synthetic oligonucleotides and impurities Authors David L. Wong and Peter Rye Agilent Technologies, Inc. Abstract This application note demonstrates…
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oligonucleotide, oligonucleotidesequence, sequenceoligonucleotides, oligonucleotidesconfirmation, confirmationcounts, countscharge, chargemass, massfragment, fragmentworkflow, workflowrna, rnaimpurities, impuritiessequences, sequencesladder, ladderdata, dataacquisition
Application Note Biopharma/Pharma An Integrated Workflow for the Analysis of Oligonucleotides and Their Impurities by Agilent High-Resolution LC/(Q-)TOF Mass Spectrometry Separation, characterization, and relative quantitation of target oligonucleotides and their impurities Authors David L. Wong and Peter Rye Agilent Technologies,…
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ttttt, tttttoligonucleotide, oligonucleotidetarget, targettpi, tpimass, massoligonucleotides, oligonucleotidescounts, countsimpurities, impuritiesrna, rnaoligo, oligosequence, sequencedeconvoluted, deconvolutedentropy, entropywere, wereagilent
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