Plasma proteomics goes high throughput – timsTOF Pro with PASEF and 4D feature alignment to quantify 500 plasma proteins in 11.5 min
Aplikace | 2019 | BrukerInstrumentace
Iontová mobilita, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
ZaměřeníProteomika
VýrobceBruker
Souhrn
Význam tématu
Analýza proteinů v krevní plazmě patří k nejdůležitějším postupům v klinické diagnostice i výzkumu biomarkerů. Komplexnost a rozsah proteinového složení plazmy vyžadují použití citlivých a vysoce propustných metod, které dokáží spolehlivě kvantifikovat stovky proteinů během krátké doby. Rozvoj vysokorychlostní LC-MS/MS kombinované s iontovou mobilitou otevírá nové možnosti pro průzkum velkých kohort lidských vzorků a umožňuje objevit a validovat dosud neznámé biomarkery.Obsah byl automaticky vytvořen z originálního PDF dokumentu pomocí AI a může obsahovat nepřesnosti.
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