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High-Throughput MS Detection of Histone H3 Demethylation by Lysine-Specific Demethylase 1 (LSD1)

 

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High-Throughput Analysis of Epigenetic Targets with Agilent RapidFire/MS Systems: Sirtuin (SIRT) Enzymes Application Note Author Introduction Peter Rye, Lauren Frick, and William LaMarr Agilent Technologies, Inc. Wakefield, MA USA Histones and other proteins are subject to a variety of posttranslational…
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Application Note High-throughput Analysis of DNA-Modifying Enzymes by an Agilent RapidFire System Author Peter Rye Agilent Technologies, Inc. Abstract Enzymes that act on DNA are promising targets for anticancer therapeutics.1 For example, the epigenetic enzyme DNMT1 is inhibited by 5-azacytidine,…
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Application Note Drug Discovery A study of SIRT1- and SIRT2‑Mediated Deacetylation Using the Agilent RapidFire high-throughput mass spectrometry system Authors Abstract Peter Rye, Lauren Frick, and William Lamarr Agilent Technologies, Inc. The Agilent RapidFire high-throughput mass spectrometry (MS) system is…
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Ultrafast Histone Deacetylase Selectivity Screening Using the Agilent RapidFire High-Throughput Mass Spectrometry System Application Note Authors Abstract Lauren E. Frick and William A. LaMarr Selectivity screening of a promising new compound requires testing against a Agilent Technologies, Inc. host of…
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