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High-Resolution Charge Variant Analysis for Top-Selling Monoclonal Antibody Therapeutics Using a Linear pH Gradient Separation Platform

 

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Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies
APPLICATION NOTE 21778 Evaluation and application of salt- and pH-based ion-exchange chromatography gradients for analysis of therapeutic monoclonal antibodies Authors Amy Farrell, Craig Jakes, and Jonathan Bones Characterization and Comparability Laboratory, NIBRT – The National Institute for Bioprocessing Research and…
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absorbance, absorbancecharge, chargevariant, variantmau, maubuffers, buffersmab, mabgradient, gradientvariants, variantsmabs, mabstherapeutic, therapeuticiex, iexsalt, saltmin, mintime, timephosphate
Thermo Bio LC Columns - See your protein therapeutics in high resolution
Thermo Bio LC Columns - See your protein therapeutics in high resolution
2020|Thermo Fisher Scientific|Brožury a specifikace
See your protein therapeutics in high resolution Bio LC Columns Contents 2 Introduction to monoclonal antibody (mAb) characterization 3 Affinity titer determination 4 Aggregate separation 5 Charge variant analysis 6 Oxidation variant analysis 11 Antibody drug conjugates (ADCs) analysis 12…
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mabpac, mabpacmab, mabhplc, hplccolumn, columncolumns, columnsformat, formatsize, sizescfc, scfcmau, mauparticle, particlemin, mincharge, chargeantibody, antibodymmae, mmaevariant
Development of pH Gradient Mobile Phase Concentrates for Robust,  High Resolution mAb Charge Variant Analysis
[ APPLICATION NOTE ] Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis Qi Wang, Susan C. Rzewuski, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Platform method…
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bioresolve, bioresolvemab, mabvariant, variantmape, mapecharge, chargeconcentrates, concentratesinitial, initialscx, scxinfliximab, infliximabbatch, batchresolution, resolutionnist, nistadalimumab, adalimumabnote, notecurve
Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column
[ APPLICATION NOTE ] Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column Hua Yang, Bill Warren, and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Method development parameters for cation Charge heterogeneity…
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bioresolve, bioresolvecharge, chargemab, mabvariant, variantscx, scxgradient, gradientminutes, minutesmonoclonal, monoclonalslope, slopeantibody, antibodysalt, saltcetuximab, cetuximabdevelopment, developmentcolumn, columnpeak
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