Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS
Aplikace | 2020 | WatersInstrumentace
LC/TOF, LC/HRMS, LC/MS
ZaměřeníKlinická analýza
VýrobceWaters
Klíčová slovacapsid, aav, adeno, uplc, virus, associated, proteins, optimizing, raav, mass, flr, therapy, gene, acquity, protein, viral, bioaccord, theoretical, recombinant, serotype, dfa, note, renders, sequence, stoichiometry, application, characterization, vectors, rda, phosphorylation, optical, observed, analysis, measurement, settings, using, raavs, modifier, detector, infectivity, judicious, intact, vps, method, throughout, difluoroacetic, mobile, chromatographic, acid, serotypes
Podobná PDF
Assessing key attributes of adeno-associated viral proteins using HPLC-FLD-intact mass analysis
2022|Thermo Fisher Scientific|Aplikace
Application note | 001120 Biopharma Assessing key attributes of adeno-associated viral proteins using HPLC-FLD-intact mass analysis Authors Application benefits Reiko Kiyonami1, Roberto Gamez1, Min • Rapid ratio assessment of adeno-associated virus (AAV) structural proteins VP1:VP2:VP3 through sensitive fluorescence detection •…
Klíčová slova
mass, massaav, aavtruncated, truncatedfld, fldviral, viralintact, intactintensity, intensitytheoretical, theoreticalrelative, relativeerror, errorppm, ppmsequence, sequenceobserved, observedprotein, proteinproteins
Developing the analytics and analytical workflows supporting the analysis of the next generation of biotherapeutic and gene therapies
2020|Waters|Prezentace
Developing the analytics and analytical workflows supporting the analysis of the next generation of biotherapeutic and gene therapies. Scott J. Berger, Ph.D. and Ximo Zhang, Ph.D. Waters Lunch Seminar Tuesday January 28, 2020 WCBP 2020 Diamond Program Partner ©2020 Waters…
Klíčová slova
capsid, capsidaav, aavempty, emptydevelopment, developmentgene, geneprotein, proteincapsids, capsidstherapy, therapysec, secproteins, proteinsfull, fullmonitoring, monitoringiex, iexrplc, rplcmeasure
PHARMSCI: Comprehensive AAV Characterizations Using HRMS: Peptide Mapping, Capsid Proteins, Intact ssDNA, and Intact Virus
2022|Waters|Postery
Comprehensive AAV Characterizations Using HRMS: Peptide Mapping, Capsid Proteins, Intact ssDNA, and Intact Virus T1430-09-53 Hua Yang, Ying Qing Yu, Stephan Koza, Suraj Dhungana, Ann Gray Waters Corporation, 34 Maple Street, Milford, Massachusetts, USA CONTACT INFORMATION: [email protected] PURPOSE RESULT(S) CONCLUSION(S)…
Klíčová slova
capsid, capsidaec, aecaav, aavcdms, cdmsssdna, ssdnapercent, percentfull, fullcharge, chargeintact, intactmass, massfraction, fractionempty, emptypredicted, predicteddetection, detectionprotein
COMPREHENSIVE AAV CHARACTERIZATIONS USING HRMS: CAPSID PROTEINS, EMPTY/FULL CAPSID RATIO AND, SSDNA ANALYSIS
2021|Waters|Postery
COMPREHENSIVE AAV CHARACTERIZATIONS USING HRMS: HRMS CAPSID PROTEINS, PROTEINS, EMPTY/FULL CAPSID RATIO AND SS SS SSDNA ANALYSIS 1 Hua Yang Yang, 2Ximo Zhang, Zhang 3Benjamin Draper, Draper 4Xiaoying Jin Jin, 4Lin Liu Liu, 4Zichuan Zhang, Zhang 1Ying Qing Yu, Yu…
Klíčová slova
ssdna, ssdnacdms, cdmsdna, dnadetec, deteccapsid, capsidaec, aecaav, aavserotypes, serotypesrplc, rplcprotein, proteinpak, pakcorrela, correlaffrac, ffractheore, theorefrac