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Extending the Lower Limits of Quantification of a Therapeutic Oligonucleotide Through Microflow LC-MS/MS

 

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Improve Sensitivity for Quantification of Antisense Oligonucleotides in Plasma Using Microflow LC-MRM Methodology Ji Jiang, Sean McCarthy, Esme Candish, Lei Xiong SCIEX, 500 Old Connecticut Path, Framingham, MA 01520 INTRODUCTION Oligonucleotide therapeutics are rapidly growing as a class of therapeutic…
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Gene Therapy and Oligonucleotide Compendium Volume 1 Gene Therapy and Oligonucleotide Compendium Contents Introduction 4 Growing trends and emerging technologies for oligonucleotide and gene therapies 6 The global gene therapy & oligonucleotide market 8 Regional landscape North America EMEAI (Europe,…
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Sensitive Quantification of Therapeutic Oligonucleotides Extracted from Plasma Featuring the SCIEX QTRAP® 6500+ LC-MS/MS System Esme Candish1, Ji Jiang1, Andrew Hart2, Susovan Mohapatra2 1 SCIEX, Framingham MA, USA, 2 Wave Life Sciences, Lexington, MA, USA Oligonucleotide therapeutics and gene therapies…
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Application note | 002568 Biopharma Sensitive LC-MS/MS quantitation of antisense oligonucleotides in plasma using the TSQ Altis Plus mass spectrometer Application benefits Authors Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of ASOs with human…
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