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Structure Characterization and Differentiation of Biosimilar and Reference Products Using Unique Combination of Complementary Fragmentation Mechanisms

Postery | 2014 | Thermo Fisher Scientific | ASMSInstrumentace
LC/HRMS, LC/MS/MS, LC/Orbitrap, LC/MS
Zaměření
Farmaceutická analýza
Výrobce
Thermo Fisher Scientific
Klíčová slova
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Application Note Biotherapeutics and Biosimilars LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab Author Suresh Babu C.V. Agilent Technologies, Inc. Abstract The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products. This Application Note presents…
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innovator, innovatorpeptide, peptidecounts, countschain, chainmapping, mappingbiosimilar, biosimilarcharge, chargeunmodified, unmodifiedptms, ptmsheavy, heavyassaymap, assaymapttppvldsdgsfflyskl, ttppvldsdgsfflysklmabs, mabsbravo, bravobiosimilars
Enhancing The Quality Of Peptide Mapping Separation For The Analysis Of PTM Application Note Biotherapeutics and Biosimilars Author Introduction Suresh Babu C.V. Post-translational modifications (PTMs) on proteins such as monoclonal antibodies (mAbs) are critical quality attributes (CQAs) that define the…
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peptide, peptidecounts, countsntaylqmnslr, ntaylqmnslradvancebio, advancebiodltmisr, dltmisrmab, mabeeeqynstr, eeeqynstrptms, ptmsdeamidated, deamidatedplus, plusdigest, digestmapping, mappingseparation, separationnonoxidized, nonoxidizedtryptic
An Integrated Workflow for Peptide Mapping of Monoclonal Antibodies Application Note Biotherapeutics and Biosimilars Authors Introduction David L. Wong Monoclonal antibodies (mAbs) represent one of the fastest growing classes of drugs in the pharmaceutical industry. As a protein drug, the…
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peptide, peptidemab, mabmapping, mappingcounts, countsassaymap, assaymapsgtasvvcllnnfypr, sgtasvvcllnnfypracquisition, acquisitionworkflow, workflowcharge, chargewere, weresequence, sequencedigestion, digestionnist, nistdiqmtqspstlsasvgdrvtitcsassr, diqmtqspstlsasvgdrvtitcsassrmtqspstlsasvgdrvtitcsassr
Middle-down Analysis of Monoclonal Antibody Middle using Nano-flow Liquid Chromatography and a Novel Tribrid Orbitrap Mass Spectrometer Jie Qian,1 Keith A. Waddell, 2 Zhiqi Hao2 1 Thermo Fisher Scientific, Somerset, NJ, 2Thermo Fisher Scientific San Jose, CA Overview Results Purpose:…
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mab, mababundan, abundanrelative, relativeetd, etdmiddle, middleabundance, abundancence, ncedown, downorbitrap, orbitrapndance, ndancemass, massabun, abundissociation, dissociationintact, intactfusion
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