<p><strong>Když se řekne české pivo, většina lidí si představí půllitr se zlatavým mokem a bohatou pěnou. Poslední roky však přinesly do pivního světa tichou revoluci. Pivo bez alkoholu. A přestože kdysi bývalo na okraji zájmu, dnes se z „nealka“ stává plnohodnotná součást české pivní scény a český konzument, důvěrně spjatý s pivní kulturou, si začíná všímat rozdílů mezi značkami a styly.</strong></p><p>Ještě před několika lety jsme nealkoholické pivo drželi v ruce jen tehdy, když jsme před sebou měli cestu autem. Dnes už po něm ale saháme z jiných důvodů – pro jeho chuť, pro zdraví, kvůli sportu nebo prostě ze zvědavosti, kam až se může české pivovarnictví bez jediné kapky alkoholu posunout.</p><h4><strong>Zrod nealkoholického piva</strong></h4><p>První nealkoholické pivo na českém území vzniklo již v <strong>sedmdesátých letech 20. století</strong>. Důvodem pro jeho výrobu ovšem nebyl strach z dopadů alkoholu na lidské zdraví nebo úsilí o zvýšení pozitivních vlastností piva, nýbrž jen potřeba podpořit bezpečnost na silnicích. Název Pito pro tento produkt vznikl spojením slov<strong> „pivo“ a „auto“</strong>. Mezi lidmi koluje mýtus, že nealkoholické pivo je jen limonáda s pivní příchutí. Pravda však je, že je to stále plnohodnotné pivo, které se vaří ze sladu, z chmele, vody a kvasnic.</p><p>Trik spočívá v řešení, jak omezit, nebo zcela odstranit alkohol, aniž zmizí autentická chuť piva. Nejjednodušší metodou výroby nealkoholického piva je uvařit <strong>nízkostupňovou mladinu</strong>, jež má na startu kvašení<strong> nízký obsah zkvasitelných cukrů</strong>, což je například takzvaná „sklářská osmička“. Pivo se proto nechá klasicky kvasit, ale v předem definované fázi se tento proces zastaví, aby nenarůstal obsah alkoholu. Kvašení lze ukončit zchlazením mladiny, nebo naopak jejím zahřátím, případně filtrací a podobně.</p><h4><strong>Moderní technologie a chuť</strong></h4><p>Ačkoliv zpočátku klasický český pivař nadále preferoval alkoholickou verzi národního nápoje, poptávka po chuťově kvalitní nealkoholické verzi od sedmdesátých let narůstala. V devadesátých letech se díky rozvíjející se pivovarské technologii již dařilo vařit piva s příjemným chuťovým profilem. Cílem bylo uvařit klasické pivo a <strong>alkohol </strong>z něj následně <strong>odstranit</strong>. K tomuto účelu se využívaly, a stále se využívají, postupy jako <strong>vakuová destilace, reverzní osmóza, dialýza a podobně</strong>.</p><p>Jedním z úskalí, která u tohoto procesu mohou nastat, je zahuštění piva, proto je nezbytné produkt na konci<br>procesu zpětně naředit vodou. To je také důvodem, proč mnoho pivařů namítá, že taková piva jsou „nudná“, „plochá“ či „nevýrazná“. Možnost vrátit pivům osobitost nabízejí<strong> jiné rody kvasinek</strong>, například Saccharomycodes ludwigii, které nezkvašují maltózu, což je hlavní cukr obsažený v pivovarské mladině. Zároveň do piva vnáší další chuťové a vonné látky jako estery a vyšší alkoholy, jež pomáhají maskovat „mladinovou“ chuť typickou pro některá jiná nealkoholická piva.</p><p>Česko, země, kde pivo patří k národní identitě stejně jako hokej nebo hrady, se k nealkoholické revoluci pivních náhražkách nebo ovocných nealkoholických variantách, nýbrž po autentickém pivu, které má říz a charakter. I dnes někteří namítají, že nealkoholické pivo není pivo, případně že je to pošlapávání tradic a české pivní kultury.</p><h4><strong>Nová kapitola pivovarnictví</strong></h4><p>Sládci proto začali experimentovat s různými styly od ležáků po IPA, dokonce i s pšeničnými pivy bez promile. Výsledek? Sortiment nealkoholických piv se rozrostl, jejich kvalita se prudce zvýšila a chuť se stala i jejich silnou stránkou. Pokud se tedy rozvine produkce nealkoholických piv, rozhodně nepřijdeme o naše české „tekuté zlato“. Spíše společnosti umožníme získat nápoj bez škodlivého alkoholu při zachování pozitivních účinků na lidský organismus. Vždyť nealkoholické pivo dnes otevírají sportovci po tréninku, cyklisté na výletech i ti, kdo chtějí prostě zůstat ve formě. V zemi, kde se pivo prolíná s každodenním životem, je to vlastně přirozený vývoj – respekt k tradici, ale i schopnost změnit návyky v souladu s dobou.<br>Češi dokazují, že i pivo bez promile může mít duši, a že „nealko“ není náhradou, ale dalším projevem naší pivní hrdosti.</p><p>Lukáš Kučera pro National Geographic.</p>

Lukáš Kučera pro National Geographic: Tradice versus nová vlna

<p>🎤 <strong>Přednášející: Simona Wawroszová</strong></p><h3><strong>VIZE 2025: Stanovení nitrosaminů v uzeninách pomocí LC-MS/MS: citlivý a robustní přístup</strong></h3><p>Nitrosaminy patří mezi významné kontaminanty v masných výrobcích, zejména v uzeninách, kde vznikají reakcí dusitanů nebo dusičnanů s aminy za kyselých podmínek či při tepelném zpracování a uzení. Jejich analytické stanovení představuje výzvu kvůli nízkým koncentracím a komplexní matrici vzorků. Moderní LC-MS/MS přístupy však umožňují jejich citlivou a selektivní detekci.</p><h4><strong>Nitrosaminy v masných výrobcích: vznik a význam</strong></h4><p>Nitrosaminy vznikají při reakci dusitanů nebo dusičnanů s aminy, typicky při technologickém zpracování masa. Mezi hlavní zdroje patří fermentované a sušené salámy, slanina nebo uzené produkty. Nejčastěji sledované sloučeniny zahrnují NDMA, NDEA, NPIP, NPYR, NMOR a NDBA.</p><p>Zdravotní význam nitrosaminů souvisí s jejich schopností tvořit v organismu reaktivní intermediáty poškozující DNA, což může vést k mutacím a zvýšenému riziku nádorových onemocnění. IARC klasifikovala zpracované masné výrobky jako prokazatelně karcinogenní mimo jiné právě kvůli jejich obsahu.</p><h4><strong>Legislativní rámec</strong></h4><p>Regulace nitrosaminů se liší podle regionu. V EU není stanoven přímý limit pro jejich obsah v masných výrobcích, ale regulován je přídavek dusitanů. Naproti tomu například USA stanovují limit pro sumu těkavých nitrosaminů ve slanině (10 µg/kg). Podobné limity existují i v Kanadě nebo Číně.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/products/554"><strong>LC-MS/MS</strong></a><strong> přístup k analýze nitrosaminů</strong></h4><p>Nitrosaminy se v potravinách vyskytují ve velmi nízkých koncentracích, proto je nutná vysoce citlivá hmotnostní spektrometrie. Metodika využívá tandemovou MS detekci v režimu MRM, která zajišťuje selektivní kvantifikaci i konfirmaci analytů.</p><h4><strong>Příprava vzorku</strong></h4><p>Pro extrakci nitrosaminů z masné matrice je použita metoda QuEChERS, která nabízí rychlou a jednoduchou přípravu vzorků. Postup zahrnuje homogenizaci vzorku, extrakci acetonitrilem s kyselinou mravenčí, přídavek solí, centrifugaci a následné čištění pomocí dSPE.</p><h4><strong>Chromatografické a MS podmínky</strong></h4><p>Separace probíhá na koloně ACQUITY UPLC CSH Phenyl-Hexyl při teplotě 40 °C a průtoku 0,6 mL/min. Mobilní fáze tvoří voda a methanol s přídavkem kyseliny mravenčí.</p><p>MS detekce využívá ionizační zdroj APCI v pozitivním módu. Optimalizace parametrů, jako jsou kolizní energie nebo napětí kužele, je realizována v <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/products/1544"><strong>softwaru waters_connect</strong></a> pomocí nástrojů pro MRM optimalizaci.</p><h4><strong>Analytické parametry a validační výsledky</strong></h4><p>Metoda dosahuje velmi nízkých limitů kvantifikace v rozpouštědle i matrici. Lineární kalibrace byla potvrzena až do 50 ng/mL s korelačními koeficienty přibližně 0,999.</p><p>V testovaných vzorcích fermentovaných salámů byly dosaženy výtěžnosti v rozmezí 89–101 % a extrapolované LOQ až 0,08 µg/kg. Tyto výsledky potvrzují vhodnost metody pro rutinní potravinářské analýzy.</p><h4><strong>Závěr</strong></h4><p>Stanovení nitrosaminů v masných výrobcích vyžaduje kombinaci citlivé detekce, selektivní analýzy a efektivní přípravy vzorků. Prezentovaná LC-MS/MS metodika s využitím QuEChERS extrakce a optimalizovaného MRM režimu poskytuje robustní řešení pro monitoring těchto kontaminantů v potravinách.</p>

Waters VIZE 2025: Stanovení nitrosaminů v uzeninách

<p><strong>V týdnu od 30. března na Vás čekají v oblasti kapalné fáze a především HPLC a LC/MS následující webináře.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://www.lcms.cz/webinars"><strong>👉 DETAILY A REGISTRACE V SEKCI WEBINÁŘE</strong></a></h4></blockquote><blockquote><p><strong>👉 Vyhledávejte a filtrujte v největší globální databázi</strong> s více než <strong>5 500 GC, HPLC, MS a spektroskopickými webináři.</strong></p></blockquote><h5><span><strong>1. Bruker: MALDI Imaging Becomes IR-resistible: Going Multimodal for Advanced Biomedical Insights</strong></span></h5><ul><li>Po, 30.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/5971">Registrace</a></li></ul><p>Prozkoumejte pokročilé multimodální zobrazování pomocí MALDI, IR založené na QCL a fluorescenční mikroskopii pro detailní molekulární analýzu komplexních tkání.</p><h5><span><strong>2. Shimadzu Corporation: Environmental PFAS Testing: Introducing Next-Generation Mass Spectrometry Solutions</strong></span></h5><ul><li>Út, 31.3.2026 09:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6026">Registrace</a></li></ul><p>Seznamte se s pokročilými strategiemi analýzy PFAS kombinující LC-MS/MS a MALDI-TOF screening pro environmentální aplikace.</p><h5><span><strong>3. Tosoh Bioscience: Tosoh Tuesday - Scaling Up from Process Development to GMP Production with Pre-packed Columns</strong></span></h5><ul><li>Út, 31.3.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6089">Registrace</a></li></ul><p>Webinář představí předplněné kolony SkillPak™ MAX a jejich využití při škálování bioprocesů s pryskyřicí TOYOPEARL® Super A pro Protein A purifikaci.</p><h5><span><strong>4. Phenomenex: Recipe for Separation: Crafting Your Perfect HPLC Method</strong></span></h5><ul><li>St, 1.4.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6091">Registrace</a></li></ul><p>Zjistěte, jak optimalizovat HPLC metody, správně pracovat s kolonami a maximalizovat jejich výkon i životnost.</p>

Webináře LabRulezLCMS týden 14/2026

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Katedra analytická chemie garantuje studijní programy pro Bc., Mgr. a Ph.D.. Disponuje špičkovými přístroji k analýzám na míru. Díky certifikaci SVP se specializujeme na spolupráci se subjekty z farmaceutického průmyslu.

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Firmu Waters založil v roce 1958 pan James Waters. Od té doby se společnost Waters specializuje na kapalinovou chromatografii a hmotnostní spektrometrii. Divize TA Instruments působí na poli termální analýzy. V České republice je Waters zastoupen přímou pobočkou, která sídlí v Praze.

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Agilent Technologies

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Phenomenex

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Evosep Biosystems

Waters Corporation

<div><div><p><strong>Let's go back to the Basics of Chromatography, Mass Spectrometry, Data Analysis and Trouble-shooting: understanding the importance of the basics will enable you to be more effective in your daily laboratory life.</strong></p><p>This journey started in 2024 and we are now pleased to invite you to join us to go deeper in fundamentals, troubleshooting and application specific topics.</p><h3><strong>EPISODE 5: MS Troubleshooting</strong></h3><p><strong>What will you learn?</strong></p><ul><li>Follow the Ion to understand important settings</li><li>DIY Maintenance</li><li>IN the Spotlight: Fluidics Systems and Ion Source option</li></ul><p><strong>What's next?</strong></p><ul><li>Check out the full Webinar Series Episodes List <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/eventRegistration/EventLobbyServlet?target=reg20.jsp&amp;eventid=4817889&amp;sessionid=1&amp;key=B9182AE813B3F8A30217606156F96B75&amp;groupId=5901784&amp;sourcepage=register"><strong>here</strong></a></li></ul><p><strong>Not sure to be able to attend live sessions?&nbsp;</strong></p><ul><li>Register today and watch the webinars on-demand</li></ul><blockquote><p><strong>Presenter: Claudia Rathmann (</strong><span>Principal F&amp;E Market Development Manager, Waters Corporation)</span></p><div><p><span>Experienced and passionate analytical science professional with over 20 years of technical and strategic expertise in food and environmental applications. Currently serving as Principal Market Development Manager at Waters Corporation, Claudia specializes in connecting customers with product management to deliver innovative solutions for complex analytical challenges. With a strong scientific foundation and a proven track record in both technical and marketing roles, Claudia bridges the gap between customer needs and product innovation across the EMEA region.</span></p></div></blockquote></div></div>

Waters Corporation: Back to Basics Advanced Webinar Series 2025

Back to Basics Advanced - Troubleshooting: MS

Follow the Ion to understand important settings. DIY Maintenance. IN the Spotlight: Fluidics Systems and Ion Source option.

<div><p><strong>Light scattering techniques, are transforming the way we quantify and analyze nucleic acid (NA) and lipid nanoparticle (LNP) therapeutics, playing a critical role in development, RNA quality assessment, and quality control. This webinar will explore how combining multi-angle light scattering (MALS) with field-flow fractionation (FFF) or size-exclusion chromatography (SEC) provides high-resolution insights into critical attributes such as size distribution, NA integrity, overall stability, and payload encapsulation.&nbsp;</strong></p><p>Recent advances in SEC column technology has increased the quality and resolution of separations for complex mixtures of large NA constructs, as well as NA-protein complexes including Cas9 constructs. FFF-MALS allows for gentle, high-resolution separation, making it ideal for analyzing NA delivery systems like LNPs without compromising their integrity. Additionally, dynamic light scattering (DLS) and electrophoretic light scattering (ELS) enable rapid, automatable batch measurements, allowing for screening of factors such as size and surface charge.</p><p>Join us to discover the latest advancements in light scattering technology and learn how these powerful tools can accelerate pharmaceutical development and enhance your research.</p><h5><strong>Key Learning Objectives:</strong></h5><ul><li>Applications of SEC-MALS to in-depth NA distribution, conformation, and stability characterization</li><li>An introduction of DLS/ELS characterization for NA and LNP formulation screening</li><li>High resolution characterization of LNPs and NA delivery vehicles via FFF-MALS for size distribution, conformation, and payload</li></ul><blockquote><p><strong>Presenter:</strong> Parker Lee, Ph.D. (Waters | Wyatt Technology)</p><p>Dr. Parker Lee is a Field Applications Scientist at Waters | Wyatt Technology, serving customers in San Diego and the surrounding areas. Dr. Lee received his Ph.D. in Macromolecular Science &amp; Engineering, with a focus on developing new methods for drug delivery. He joined Wyatt Technology in 2022 after five years of work in macromolecule analytical development for various startups. As a Field Applications Scientist, he is responsible for working with customers to ensure they can utilize Wyatt’s light scattering instrumentation effectively to improve and accelerate their research.</p><p><strong>Presenter:</strong> Lavelay Kizekai, Ph.D. (Waters Corporation)</p><p>Lavelay Kizekai, BS, is a principal scientist at Waters Corporation. He joined Waters in 2009 and has since applied himself to developing new LC methods, leading column technology product development work, and establishing insight-based QC procedures for Waters products. His primary area of focus is biomolecule separations using size-exclusion chromatography (SEC). He was a core member of the team that recently brought to market a column suited to platform methods for monoclonal antibodies and antibody-drug conjugates. He is currently leveraging these SEC technologies and even newer breakthroughs for the characterization of gene-based therapeutics by multiangle light scattering.</p></blockquote></div>

Waters Corporation: Beyond Batch Methods: High Resolution Nucleic Acid and LNP Insights with Light Scattering Techniques

Beyond Batch Methods: High Resolution Nucleic Acid and LNP Insights with Light Scattering Techniques

Discover latest advancements in light scattering technology and learn how these tools can accelerate pharmaceutical development

High-Res Nucleic Acid & LNP Analysis via Light Scattering

<p>&nbsp;<strong>Key Learning Points</strong></p><ul><li>Learn best practices to optimize and utilize SLE for biological sample matrices</li><li>Review case studies to understand advantages of SLE and its limitations</li><li>Understand sustainable solvent use for SLE</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Scientists and researchers pursuing research on low level analyte quantitation using LC-MS/MS.</li></ul><blockquote><p><strong>Speaker: </strong>Rajashree Chakravarti, Ph.D. (Global Product Manager, Phenomenex)</p><p>Rajashree Chakravarti, Ph.D., is a Global Product Manager at Phenomenex. With over a decade of experience in clinical diagnostics and research, she has a robust background in chromatography and mass spectrometry. Rajashree is a key contributor in innovation and new product development at Phenomenex, driving advancements in analytical techniques and solutions.</p></blockquote>

Phenomenex: Advancing Supported Liquid Extraction (SLE) with Strata SE – A Clean and Sustainable Solution

Advancing Supported Liquid Extraction (SLE) with Strata SE – A Clean and Sustainable Solution

Learn best practices to optimize and utilize SLE for biological sample matrices

Advancing Supported Liquid Extraction SLE with Strata SE

<h4><strong>Waters 2025 LC Symposium</strong></h4><p><strong>Waters 2025 LC Symposium – LC Solutions for Emerging Therapeutics</strong></p><h5><strong>Overview</strong></h5><p>Liquid chromatography plays a critical role in ensuring the safety of emerging therapeutics such as PROTACs, cell and gene therapies, and GLP-1 drug products. Join this free symposium to gain insights from forward-thinking global leaders in LC technology. You will learn about the latest advancements addressing analytical and purification challenges posed by these transformative therapeutics.</p><h5><strong>Learning objectives</strong></h5><ul><li>Learn how our experts are handling unique analytical challenges in emerging therapeutics&nbsp;</li><li>Explore advanced LC technologies applied to critical issues in PROTACs, cell and gene therapies, and GLP-1 drugs</li><li>Pose your questions to our expert panel on your analytical challenges with emerging therapeutics</li></ul><h5><strong>Who should attend</strong></h5><ul><li>LC scientists, managers and directors from the pharmaceutical industry</li></ul><h4><br><strong>Day 2: Purification and QC Release of GLP-1 Analogs: From Characterization to Final Approval</strong></h4><p>As peptide-based drugs like liraglutide, semaglutide, and tirzepatide gain prominence in treating type 2 diabetes and supporting weight management, ensuring their purity is more critical than ever. This session explores the essential role of chromatography in the purification, impurity profiling, and release testing of these complex therapeutics.</p><p>Experts from Neopharm Labs and Waters Corporation will share real-world case studies on peptide purification and impurity analysis using advanced LC technologies. The session will also highlight how Waters’ hyphenated LC-UV/MS workflows can streamline impurity identification, reduce analytical workload, and accelerate development timelines.</p><p>Ideal for scientists involved in peptide drug development, this session offers practical insights into modern purification strategies and analytical tools that support the successful development and release of GLP-1 analogs.</p><blockquote><p><strong>Presenter:</strong> Michael R. Miller (Principal Scientist, Neopharm Boston)</p><p>Michael has worked at Neopharm Boston for 4 years and has over 10 years of chromatographic and mass spectrometric experience. At SUNY University at Albany, he studied RNA Biochemistry and LC-MS/MS analysis of large RNAs. Joining Neopharm Boston in 2021 as an Analytical Scientist, Michael spent two years performing HPLC and SFC separations at analytical and preparative scale. Moving up to Lab Supervisor and ultimately Principal Scientist he using his large molecule knowledge to bring Neopharm Boston into the large molecule space.</p><p><strong>Presenter: </strong>Duanduan Han, Ph.D. (Senior Scientist, Waters Corporation)</p><p>Duanduan joined Waters in 2021. Her work has focused on LC/MS method development and troubleshooting, impurity profiling, raw material screening of GLP-1, lipid nanoparticle, surfactant, oligonucleotide, mAb, and other biologic drug products. She received her PhD of chemical engineering from the Texas A&amp;M University.</p><p><strong>Moderator: </strong>Arjan Timmerman (Pharma Market Development Manager EMEA, Waters Corporation)</p><p>Arjan Timmerman is a market development manager at Waters working in EMEA. Prior to joining Waters in 2014 he worked for 17 years as an Analytical Scientist in the Small Molecule Pharmaceutical industry in various Chemical and Pharmaceutical late-stage development labs.</p><p>Since 2023 he became QA/QC market development manager for EMEA working in a dedicated team and focuses on Pharmaceutical workflows, AQbD, Impurities, LC Chromatography and Compliance.</p></blockquote>

Waters Corporation: Waters 2025 LC Symposium - LC Solutions for Emerging Therapeutics

Waters 2025 LC Symposium - Day 2 - GLP-1 Analog Development: Purification, Characterization, Release Testing

Learn how advanced LC and LC-UV/MS help purify and profile impurities in GLP-1 drugs like semaglutide. Real-world case studies from Neopharm Labs and Waters.

GLP-1 Analog Purification, Characterization, Release Testing

<p><strong>Veterinary drug residues are substances that can remain in animal products such as meat, dairy, eggs, and fish when these drugs are used to treat, prevent, or manage diseases in food-producing animals. These residues are of concern due to their potential to cause adverse effects on human health, including antimicrobial resistance (AMR), allergic reactions, and even carcinogenic or teratogenic outcomes. In light of these risks, countries and international regulatory bodies, such as the Codex Alimentarius and various governmental health agencies, have established maximum residue limits (MRLs) for specific drugs in food products. The control of these residues is critical not only for consumer safety but also for maintaining the integrity of food production systems globally.</strong></p><p>Join us for an in-depth webinar to gain insights into the latest regulatory requirements and analytical techniques for detecting veterinary drug residues in various food matrices. Learn how advanced technologies can enhance food safety and streamline testing processes.</p><h5><strong>By attending this presentation, you will learn about:</strong></h5><ul><li>Understanding regulations and MRL values for veterinary drugs</li><li>Innovative sample preparation methods to achieve low LOQs</li><li>Validation procedures, including single-laboratory validation (SLV) and multi-laboratory validation (MLV).</li><li>Utilizing the SCIEX 7500+ system for high-sensitivity quantitation and interference removal</li></ul><h5><strong>Who should attend:</strong></h5><ul><li>Food safety and quality control professionals</li><li>Analytical chemists and laboratory technicians</li><li>Regulatory affairs specialists in the food industry</li></ul><blockquote><p><strong>Presenter: </strong>Jianru Stahl-Zeng (Senior Technical Marketing Manager, SCIEX)</p></blockquote>

Separation Science: Advancing Food Safety and Regulatory Compliance: Comprehensive Screening of Veterinary Drug Residues in Food using SCIEX LC-MS/MS Technology

Advancing Food Safety and Regulatory Compliance: Comprehensive Screening of Veterinary Drug Residues in Food using SCIEX LC-MS/MS Technology

Gain insights into the latest regulatory requirements and analytical techniques for detecting veterinary drug residues in various food matrices.

Screening Vet Drug Residues in Food with SCIEX LC-MS/MS

<p><strong>Missed the big launch at ASMS 2025? We’ve got you covered. Join this session to get the full story and discover how Evosep Eno simplifies workflows and supports labs of all sizes.</strong></p><p>The Evosep Eno represents a significant leap forward in proteomics technology — delivering the speed, precision, and reproducibility needed to transform drug discovery and translational research.</p><blockquote><p><strong>Presenter:</strong> Tim Heymann (Mass Spectrometry Specialist at Max Planck Institute of Biochemistry)&nbsp;</p><p><strong>Presenter:</strong> Ulises Hernández-Guzmán (Assistant Research Scientist at Novo Nordisk Foundation Center for Protein Research, University of Copenhagen)</p></blockquote>

Evosep Biosystems: Evosep Eno: A New Era of Speed, Scale and Robustness

Evosep Eno: A New Era of Speed, Scale and Robustness

Join this session to get the full story and discover how Evosep Eno simplifies workflows and supports labs of all sizes.

Evosep Eno New Era of Speed, Scale and Robustness

<p><strong>A 3-part webinar series to help you stay ahead in nitrosamines &amp; NDSRI analysis, from regulatory clarity to method mastery and compliance confidence.</strong></p><h4><strong>Session 1: Nitrosamines Landscape in Tandem with Analytical Technologies: Is Your Lab Nitrosamine Ready?</strong></h4><p><strong>Nitrosamines and NDSRIs continue to challenge the pharmaceutical industry with evolving regulations and analytical complexities. This session focuses on understanding the distinctions between nitrosamines and NDSRI's and aligning your lab with the latest regulatory expectations and technology advancements.</strong></p><p>Get expert insights into risk assessment, mitigation strategies, and the analytical technologies critical to staying compliant and efficient. The session will feature an exclusive panel discussion with Dr. Saji Thomas, Associate Vice President, Analytical Research &amp; Development, Sun Pharma, who will share practical, real-world insights from the frontlines of nitrosamine testing and regulatory preparedness.</p><h5><strong>Key Takeaways:</strong></h5><ul><li>Understanding the difference between Nitrosamines and NDSRI's</li><li>Regulatory scenarios: API, Formulations, and NDSRI's</li><li>Key updates in global guidance and risk assessment</li><li>Mitigation strategies for NDSRI's</li><li>Industry discussion: evolving testing landscape, workflow challenges, and future directions</li><li>Live Q&amp;A with Agilent and industry experts</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Saji Thomas (Associate Vice President, Analytical Development, Sun Pharmaceutical Industries Limited)</p><p>Dr. Saji Thomas earned his Ph.D. in chemistry from Kumaun University, Nainital, Uttarakhand. With 32 years of diverse experience in the pharmaceutical industry, he has developed cost-competitive, IP, EHS, and regulatory-compliant technologies for generic APIs, intermediates, radiopharmaceuticals, onco APIs, life science ingredients, animal nutrition products, fine chemicals, CRAMS/CDMO, and drug discovery functions.</p><p>He is skilled in chemical analysis, chromatography, solid-state characterization, spectroscopy, impurity profiling, impurity isolation, and structural elucidation using techniques such as LC-MS/MS, HRMS, IR, NMR, and EA. Also excels in developing and validating highly sensitive MS methods for nitrosamines, NDSRIs, and GTIs.</p><p>He has extensive experience in pharmaceutical quality management systems (QMS), creating state-of-the-art manufacturing and QA systems, conducting OOT and OOS investigations, identifying root causes, implementing CAPA, and engaging in FDA remediation activities. He is a co-inventor of 25 process patents and has published 14 research papers in international journals.</p><p>Currently, Dr. Thomas serves as the Associate Vice President of Analytical Development at Sun Pharmaceutical Industries Limited in Gurugram. His previous roles include positions at Jubilant Pharmova Limited, Indoco Remedies, Jubilant Life Sciences Limited, Solaris Chemtech, and Alta Laboratories Limited.</p><p><strong>Presenter:</strong> Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)</p><p>Kuldeep Sharma has over 19 years of experience in the areas of bioanalytical research, drug metabolism &amp; pharmacokinetics, and pharma regulatory compliance. He has accomplished a PhD in biotechnology. His professional journey covers over 12 years in analytical research (associated with R&amp;D at Zydus Cadila, Lambda, Pliva, and Jubilant Biosys) and the last 7 years in analytical instrument sales, marketing, and business development. With over 21 research articles published in international journals, he presents the convention of continuous learning.</p></blockquote>

Agilent Technologies: Nitrosamines Navigator: Be Confident with Agilent Workflows

Nitrosamines Landscape in Tandem with Analytical Technologies: Is Your Lab Nitrosamine Ready?

Is your lab nitrosamine-ready? Join Session 1 to explore regulatory trends, risk strategies, and tech updates with expert insights from Sun Pharma and Agilent.

Is Your Lab Nitrosamine Ready?

<div id="contentLeft"><div id="realLeftContent"><div id="summary2" dir="ltr" aria-live="off"><div><div dir="" aria-atomic="true"><p><strong>Ion chromatography (IC) has long been a trusted technique for ionic analysis, with conductivity detection as its standard workhorse. However, alternate detection technologies are unlocking new possibilities for sensitivity, selectivity, and broader application coverage. In this webinar, we’ll explore three powerful alternatives: UV/Vis, amperometric, and mass spectrometry (MS) detection, and examine how each can enhance your IC workflows.</strong></p><p>We’ll discuss practical examples of when to apply each detection method, helping you understand which technologies are best suited for different analytes, sample types, and industry needs. Whether you're analyzing food and beverage products, monitoring environmental contaminants, or working with other complex matrices, alternate detectors can offer significant advantages. Along the way, we’ll share key insights on optimizing your methods for each detector type—covering considerations like system setup, sample prep, and choosing the right chemistry. Whether you're expanding into new applications or looking to refine existing methods, this session will offer actionable guidance to help you get the most out of your IC system.</p><h4><strong>Who should attend?</strong></h4><ul><li>Analytical chemists and method development scientists looking to expand or refine their use of ion chromatography</li><li>Lab managers and technical staff seeking to evaluate or implement alternate detection technologies</li><li>Professionals in environmental, food, pharmaceutical, or industrial sectors aiming to enhance analytical capabilities</li></ul><h4><strong>Key learning points</strong></h4><ul><li>Learn the core principles and application benefits of UV/Vis, amperometric, and mass spectrometry (MS) detection in ion chromatography</li><li>Understand how to choose the right detection method based on sample type, analyte characteristics, and application requirements</li><li>Explore practical method development tips to optimize performance with each detection technology</li></ul><blockquote><p><strong>Presenter: </strong>Jay Gandhi. PhD (Vertical Market Manager, Metrohm USA)</p><p>Dr. Gandhi brings 38+ years of proficiency with virtually all analytical instrumentation and the techniques of Environmental, Petrochemical and Pharmaceutical testing and research. Jay is currently involved with the development of «Total Fluorine» analysis using combustion ion chromatography (CIC). Since 2003, Dr. Gandhi is a non-paid adjunct faculty at University of Houston-Clearlake where he enjoys guiding graduate and post-graduate students in their independent study program.</p><p><strong>Presenter: </strong>Bikash Chouhan, PhD (Applications Specialist, Ion Chromatography, Metrohm USA)</p><p>Bikash Chouhan is an Applications Specialist for Ion Chromatography at Metrohm USA. He completed his PhD in Analytical Chemistry from the University of Texas at Arlington (UTA). His area of research during his PhD was in Capillary Scale Ion Chromatography. He has worked as a Post Doc at Department of Chemistry and Biochemistry, UTA and as a Senior Scientist in IC at Eurofins, before joining Metrohm USA. He is currently involved in expanding IC applications to more unique and challenging sample matrices.</p></blockquote></div></div></div></div></div>

Metrohm: Expanding Ion Chromatography with Advanced Detection Technologies

Expanding Ion Chromatography with Advanced Detection Technologies

Boost your IC performance with UV/Vis, amperometric, and MS detection. Learn when and how to apply alternate detectors for better sensitivity and selectivity.

Expanding IC with Advanced Detection Technologies

<p>Webinář pořádá společnost <strong>ANAMET s.r.o.</strong> ve spolupráci se společností <strong>nanoFCM. Hostujícím řečníkem bude:</strong></p><ul><li>Freya Leech (nanoFCM, Velká Británie)</li></ul><h5><strong>Co se na webináři dozvíte:</strong></h5><ul><li>Představení přístroje <strong>NANOAnalyzer</strong> – unikátního průtokového cytometru navrženého pro analýzu nanočástic</li><li>Aplikační ukázky na <strong>extracelulárních vezikulách, virových částicích, lipozomech</strong></li><li>Prostor pro Vaše <strong>dotazy formou chatu</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Nano_FCM_NANOANALYZER_809953ffe2.jpg" alt="NanoFCM: NANOANALYZER" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Nano_FCM_NANOANALYZER_809953ffe2.jpg 201w," sizes="100vw" width="871" height="674"></p><p><strong>V případě zájmu prosím neváhejte s registrací.</strong></p><p><strong>Těšíme se na setkání online!</strong></p><p>S přátelským pozdravem,<br>Mgr. Hynek Mácha, Ph.D. (ANAMET s.r.o.)</p>

LabRulez / AI: Charakterizace nanočástic průtokovou cytometrií nanoFCM

Charakterizace nanočástic průtokovou cytometrií nanoFCM

Webinář: NANOAnalyzer – průtoková cytometrie pro analýzu nanočástic. Ukázky na EV, virech, lipozomech. Prostor pro dotazy. Registrujte se!

<p><strong>Despite the incredible advances in metabolomics, translating vast amounts of untargeted data into meaningful biological insights remains a major challenge. Many metabolites go unidentified, limiting the impact of these powerful techniques on real-world applications. This event brings together leading experts to discuss strategies and technologies that can bridge this gap and enhance metabolite identification.</strong></p><p>Gain insights from experts in a two-part discussion: a master class highlighting key metabolomics challenges and solutions, followed by a roundtable discussion featuring industry leaders tackling the bottlenecks in metabolite identification. Choose to attend one or both sessions.</p><h4><strong>Part 1: Master class: Lost in translation – advancing untargeted metabolomics</strong></h4><p>Dr. Philippos Michopoulos from Astrazeneca will share his insights into the key challenges of metabolite identification in untargeted workflows, including:</p><ul><li>The limitations of current retention time libraries and how much information remains untapped</li><li>The role of untargeted SWATH acquisition and data mining in improving metabolite identification</li><li>Practical strategies for closing the gap between experimental data and meaningful biological interpretation</li></ul><p>This session will feature a discussion with SCIEX experts on potential solutions.</p><blockquote><p><strong>Presenter: </strong>Filippos Michopoulos (Astrazeneca)</p><p>Filippos Michopoulos is an analytical chemist who has obtained his PhD from University of Thessaloniki (Greece) in “Biomarker Discovery and drug efficacy in studying autoimmune diseases”. Filippos has 20 years of experience in metabolic profiling technologies across the academia and industry. Filippos has developed a wide range of robust analytical technologies using U(H)PLC separations hyphenated to mass spectrometry predominantly focused on polar metabolite analysis and quantitation. He is interested to utilise advancements in analytical science to unravel biological complexity and enhance understanding of pathophysiological mechanism. Filippos has more than &gt;30 peer reviewed scientific publication and an active reviewer in &gt;10 scientific journals.</p><p><strong>Presenter: </strong>Ferran Sanchez (Market Development Manager, Pharma/CRO (MS &amp; CE), EMEAI, SCIEX)</p><p>Ferran obtained his PhD in Pharmaceutical Sciences at the University of Barcelona in 2005 and has been involved with mass spectrometry ever since. He has worked for SCIEX for 18 years holding different positions in sales, marketing and business development covering the EMEAI region. During this time, Ferran has been working closely with customers in the pharmaceutical industry to deepen his understanding of the market and user needs for delivering the right solutions at the right time.</p><p><strong>Presenter:&nbsp;</strong>Martin Giera, Ph.D.</p><p>Martin Giera, Ph.D., studied pharmacy in Heidelberg and Munich. He is professor for translational metabolomics and lipidomics and vice-chair of the center for proteomics and metabolomics at the Leiden University Medical Center. He is involved in several multi-national consortia, member of several editorial boards and chairman of the interdisciplinary committee at FWO. Martin has a keen interest in metabolomics technology, drug development and biochemistry. He has published more than 250 scientific publications, patents and books.</p></blockquote>

SCIEX: Metabolomics during the Drug Discovery: Master class and roundtable discussion

Master class: Lost in translation – advancing untargeted metabolomics

Explore key challenges in untargeted metabolomics and discover strategies to improve metabolite ID with SWATH data and insights from AstraZeneca and SCIEX.

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