High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition
Aplikace | 2020 | Agilent TechnologiesInstrumentace
Příprava vzorků, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, LC/QQQ
ZaměřeníKlinická analýza
VýrobceAgilent Technologies
Klíčová slovarapidfire, nadph, inhibitor, naph, midazolam, remaining, activity, inhibition, cyp, azamulin, drug, cytochrome, ritonavir, without, throughput, incubations, traditional, adme, fda, diltiazem, concentration, inhibitors, substrates, dependent, vitro, experiments, system, vaughn, produces, were, chlorzoxazone, hlm, validated, discovery, indicate, seven, probe, microsomes, miller, bupropion, conventional, termination, individual, time, productive, testosterone, process, pooled, adverse, earlier
Podobná PDF
High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition
2020|Agilent Technologies|Aplikace
High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…
Klíčová slova
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remainingactivity, activityinhibition, inhibitioncyp, cypazamulin, azamulindrug, drugcytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput Analysis of Cytochrome P450 Inhibition in Intact Human Hepatocytes
2014|Agilent Technologies|Aplikace
High-Throughput Analysis of Cytochrome P450 Inhibition in Intact Human Hepatocytes Application Note Authors Abstract Kari E. Schlicht and Vaughn P. Miller Ultrafast methods of analysis were developed using the Agilent RapidFire Agilent Technologies, Inc. High‑Throughput Mass Spectrometry System in combination…
Klíčová slova
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfireactivity, activitysensor, sensorvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonecryopreserved, cryopreservedthroughput
Development of Label-Free, Enzymatic CYP17A1 Assays Using the Agilent 6150 Single Quadrupole LC/MS System
2011|Agilent Technologies|Aplikace
Development of Label-Free, Enzymatic CYP17A1 Assays Using the Agilent 6150 Single Quadrupole LC/MS System Application Note Authors Abstract Robert Wurm and Kenneth Lewis OpAns, LLC Durham, NC USA This application note describes the development of fast, label-free in vitro enzymatic…
Klíčová slova
substrate, substratecounts, countsproduct, productfinal, finaldepletion, depletioninhibitor, inhibitorhydroxylase, hydroxylasemin, minreaction, reactiontime, timemetconazole, metconazoleassay, assaytesticular, testicularconcentration, concentrationnces
Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS
2013|Agilent Technologies|Aplikace
Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS Application Note Authors Introduction Lauren E. Frick and William A. LaMarr Agilent Technologies, Inc. Wakefield, MA, USA Fragment-based screening offers advantages over…
Klíčová slova
unlabeled, unlabeledlfs, lfssubstrate, substratehits, hitslabeled, labeledums, umslms, lmsrapidfire, rapidfirewere, werepeptide, peptideassays, assaysfluorescently, fluorescentlyhit, hitautofluorescence, autofluorescenceinhibition
