Characterization of IgG1 monoclonal antibody (mAb) oxidation variants at intact, subunit and peptide levels
Aplikace | 2020 | Thermo Fisher ScientificInstrumentace
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
ZaměřeníKlinická analýza
VýrobceThermo Fisher Scientific
Klíčová slovaipilimumab, oxidation, hotspots, stressed, isr, nibrt, mass, dtlmisr, control, thermo, relative, scientific, pinpoint, unmodified, localization, duo, methionine, hcd, abundance, digested, scheffler, dtlm, specific, site, identification, peptide, fisher, kingfisher, xtract, guanidine, kai, intensity, proteolytic, spectral, cqa, enables, routines, denatured, subunit, deployed, using, automated, clarity, degraded, hydrochloride, forced, levels, acquisition, translational, level
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Assessing Oxidation in IgG1 Monoclonal Antibodies and Correlating at both Intact Protein and Peptide Levels
2020|Thermo Fisher Scientific|Postery
Assessing Oxidation in IgG1 Monoclonal Antibodies and Correlating at both Intact Protein and Peptide Levels Tom Buchanan1, Sara Carillo2, Kristina Srzentić3, Kai Scheffler4, Angela Criscuolo4, Silvia Millan Martin2, Jennifer Sutton5, Phil Widdowson1, Ken Cook1, Jonathan Bones2. 1Thermo Fisher Scientific, Hemel,…
Klíčová slova
ipilimumab, ipilimumabgolimumab, golimumabdtlmisr, dtlmisrintact, intactcontrol, controlstressed, stressedδmass, δmasssubunit, subunitabundance, abundancehcd, hcdrelative, relativeunmodified, unmodifiedfull, fullmin, minpeptide
Complete characterization of monoclonal antibodies under native and denaturing conditions
2021|Thermo Fisher Scientific|Aplikace
APPLICATION NOTE 73885 Complete characterization of monoclonal antibodies under native and denaturing conditions Kristina Srzentić1, Eugen Damoc2, Kai Scheffler3, Tom Buchanan4, Krisztina Radi4, Jennifer Sutton1 Thermo Fisher Scientific, 1 Cambridge, Massachusetts, US 2 Bremen, Germany 3 Germering, Germany 4 Hemel…
Klíčová slova
intact, intacttrastuzumab, trastuzumabnative, nativemass, masshcd, hcdmab, mabsubunit, subunitthermo, thermodown, downdeconvolution, deconvolutionscientific, scientificsubunits, subunitspeptide, peptidemiddle, middleheavy
Accelerating monoclonal antibody peptide mapping with high acquisition speed Orbitrap-based MS
2020|Thermo Fisher Scientific|Aplikace
APPLICATION NOTE 73672 Accelerating monoclonal antibody peptide mapping with high acquisition speed Orbitrap-based MS Authors: Phil Widdowson, Amy Claydon, Tom Buchanan Thermo Fisher Scientific, Hemel Hempstead, UK Keywords: Peptide mapping, monoclonal antibody, mAb, post-translational modification, PTM, high throughput analysis, golimumab,…
Klíčová slova
golimumab, golimumabterminal, terminaldeamidation, deamidationglycosylation, glycosylationpeptide, peptidelysine, lysinemodification, modificationmapping, mappingdigest, digestrelative, relativeoxidation, oxidationpeptides, peptidespyroglu, pyroglusmart, smartmodifications
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid Quadrupole- Orbitrap Mass Spectrometer
2020|Thermo Fisher Scientific|Postery
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher…
Klíčová slova
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrrelative, relativesigma, sigmacharacterization, characterizationmonoclonal, monoclonalmab
