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Complete characterization of monoclonal antibodies under native and denaturing conditions

Aplikace | 2021 | Thermo Fisher ScientificInstrumentace
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Zaměření
Farmaceutická analýza
Výrobce
Thermo Fisher Scientific
Klíčová slova
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Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher…
Klíčová slova
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrrelative, relativecharacterization, characterizationsigma, sigmamonoclonal, monoclonalides
RES MS analysis of antibodies at the protein and peptide levels is critical during development and production of biopharmaceuticals. The compositions of current generation therapeutic proteins are often complex due to their heterogeneity caused by various modifications which are relevant…
Klíčová slova
abundance, abundancelys, lystrastuzumab, trastuzumabrelative, relativeinfliximab, infliximabdisulfide, disulfidenative, nativebevacizumab, bevacizumabzoom, zoomxtract, xtractslslspgkc, slslspgkcslslspg, slslspgchain, chainintact, intactreduced
A comprehensive CE/ESI-MS solution for BioPharma applications Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometers with ZipChip system Fast CE Separation Nanospray Sensitivity HRAM Spectrometry A unique and powerful combination of CE/ESI and MS technology designed for BioPharmaceutical applications Thermo…
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zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativeabundance, abundancefinder, findermab, mabmass, massemtasine, emtasineoption, optionlysine, lysinetrastuzumab, trastuzumabcarbohydrates, carbohydratesides, idesinfliximab
Assessing Oxidation in IgG1 Monoclonal Antibodies and Correlating at both Intact Protein and Peptide Levels Tom Buchanan1, Sara Carillo2, Kristina Srzentić3, Kai Scheffler4, Angela Criscuolo4, Silvia Millan Martin2, Jennifer Sutton5, Phil Widdowson1, Ken Cook1, Jonathan Bones2. 1Thermo Fisher Scientific, Hemel,…
Klíčová slova
ipilimumab, ipilimumabgolimumab, golimumabdtlmisr, dtlmisrintact, intactcontrol, controlstressed, stressedδmass, δmasssubunit, subunitabundance, abundancehcd, hcdrelative, relativeunmodified, unmodifiedfull, fullmin, minpeptide
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LabRulez s.r.o. Všechna práva vyhrazena. Obsah dostupný pod licencí CC BY-SA 4.0 Uveďte původ-Zachovejte licenci.