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3D spheroid culture as a tool for studying drug metabolism

 

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High-Throughput Analysis of Cytochrome P450 Inhibition in Intact Human Hepatocytes Application Note Authors Abstract Kari E. Schlicht and Vaughn P. Miller Ultrafast methods of analysis were developed using the Agilent RapidFire Agilent Technologies, Inc. High‑Throughput Mass Spectrometry System in combination…
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hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfireactivity, activitysensor, sensorvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonecryopreserved, cryopreservedthroughput
Metabolism study of the novel cathinone derivative 3-MMC combining three in vitro approaches, LC-HRMS acquisition and Eliès Zarrouk ; Alan Barnes ; Stephane Moreau ; Neil Loftus ; Sylvain Dulaurent ; Souleiman Elbalkhi ; Franck Saint-Marcoux molecular networking tools CHU…
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heparg, hepargmetabolites, metabolitesscreening, screeningbiotransformations, biotransformationsmicrosomes, microsomesexpression, expressionprecursor, precursorapplied, appliedgene, geneelbalkhi, elbalkhieliès, elièsmetaphedrone, metaphedronehuman, humananalyze, analyzedulaurent
Agilent LC/Q-TOF and Mass MetaSite Software for Seamless Metabolite Identification Application Note Small Molecule Pharmaceuticals Author Abstract Siji Joseph The detection and identification of metabolites is a critical step in the early drug Application Scientist discovery phase. The identification of…
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metasite, metasiteidentification, identificationmetabolite, metabolitewarfarin, warfarinhydroxywarfarin, hydroxywarfarinmetabolites, metabolitesfiltering, filteringidentified, identifiedmass, massregio, regiotof, tofdrug, drugmetabolism, metabolismhepatocytes, hepatocytessoftware
TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS Mark Towers1, Lisa Reid1, Alicia Rosell-Hidalgo2, Kirsten Headspith2 1 Waters Corporation, Wilmslow, Cheshire, UK 2 Cyprotex Ltd., Alderley Park, Cheshire, UK INTRODUCTION RESULTS AND DISCUSSION Dilution series Carbamazepine…
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perhexiline, perhexilinespheroids, spheroidsspheroid, spheroiddesi, desicarbamazepine, carbamazepinedosing, dosingspheriods, spheriodsimaging, imagingwarfarin, warfarindmso, dmsowere, werewithin, withindetected, detectedcompounds, compoundsknown
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