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3D spheroid culture as a tool for studying drug metabolism

 

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High-Throughput Analysis of Cytochrome P450 Inhibition in Intact Human Hepatocytes
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hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfireactivity, activitysensor, sensorvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonecryopreserved, cryopreservedthroughput
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heparg, hepargmetabolites, metabolitesbiotransformations, biotransformationsscreening, screeningmicrosomes, microsomesexpression, expressionprecursor, precursorapplied, appliedgene, geneelbalkhi, elbalkhieliès, elièsmetaphedrone, metaphedronehuman, humananalyze, analyzedulaurent
Agilent LC/Q-TOF and Mass MetaSite Software for Seamless Metabolite Identification
Agilent LC/Q-TOF and Mass MetaSite Software for Seamless Metabolite Identification Application Note Small Molecule Pharmaceuticals Author Abstract Siji Joseph The detection and identification of metabolites is a critical step in the early drug Application Scientist discovery phase. The identification of…
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metasite, metasiteidentification, identificationmetabolite, metabolitewarfarin, warfarinhydroxywarfarin, hydroxywarfarinmetabolites, metabolitesfiltering, filteringidentified, identifiedmass, massregio, regiotof, tofdrug, drugmetabolism, metabolismhepatocytes, hepatocyteshepatocyte
IMSIS: TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS
TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS Mark Towers1, Lisa Reid1, Alicia Rosell-Hidalgo2, Kirsten Headspith2 1 Waters Corporation, Wilmslow, Cheshire, UK 2 Cyprotex Ltd., Alderley Park, Cheshire, UK INTRODUCTION RESULTS AND DISCUSSION Dilution series Carbamazepine…
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perhexiline, perhexilinespheroids, spheroidsspheroid, spheroiddesi, desicarbamazepine, carbamazepinedosing, dosingspheriods, spheriodsimaging, imagingwarfarin, warfarindmso, dmsowere, werewithin, withindetected, detectedcompounds, compoundsknown
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