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Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q‑TOF

 

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Poster Reprint ASMS 2020 WP 004 Mass Spectrometric Characterization of Antibody-RNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q-TOF David L. Wong Agilent Technologies, Inc., Santa Clara, CA, USA Introduction Experimental Antibody-RNA Conjugates have drug-like The antibody was partially reduced with…
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conjugates, conjugatesrna, rnamab, mabantibody, antibodycondition, conditionadvancebio, advancebiounder, undersirna, sirnanative, nativedenaturing, denaturingthiomab, thiomabintact, intactdelivery, deliveryspanned, spannedpayloads
Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…
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dimension, dimensiondar, daradcs, adcsadc, adcsecond, secondnative, nativehic, hicadvancebio, advancebiocounts, countsmab, mabdrug, drugdeconvoluted, deconvolutedfirst, firstconjugated, conjugatedintact
Application Note Pharma & Biopharma Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS Author David L. Wong Agilent Technologies, Inc. Abstract Native mass spectrometry can be used for a variety of protein-based applications, such as protein-protein interaction, protein-ligand…
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native, nativeprotein, proteincounts, countsintact, intactdeconvoluted, deconvolutedamu, amumyoglobin, myoglobinmass, massapomyoglobin, apomyoglobincharge, chargeheme, hemecomplexes, complexesholomyoglobin, holomyoglobintetramer, tetramerdenatured
Agilent-NISTmAb Intact & Subunit Analysis Using Reversed Phase Agilent BioHPLC Columns Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test…
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counts, countsmab, mabherceptin, herceptinintact, intactpage, pagecontents, contentsbonds, bondsback, backdeglycosylated, deglycosylateddeconvoluted, deconvolutedmass, massides, idesamu, amubravo, bravoassaymap
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