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A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS

Aplikace | 2020 | Agilent TechnologiesInstrumentace
Příprava vzorků, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Zaměření
Farmaceutická analýza
Výrobce
Agilent Technologies
Klíčová slova
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Application Note Biotherapeutics and Biosimilars Profiling Glycosylation of Monoclonal Antibodies at Three Levels Using the Agilent 6545XT AdvanceBio LC/Q‑TOF Author Introduction David L. Wong Agilent Technologies, Inc. Santa Clara, CA, USA Monoclonal antibodies (mAbs) and their derivatives represent a very…
Klíčová slova
glycan, glycanmab, mabglycoforms, glycoformsnistmab, nistmabquantitation, quantitationintact, intactglycans, glycansagilent, agilentassaymap, assaymapadvancebio, advancebiomapping, mappingbioconfirm, bioconfirmbravo, bravocounts, countsdeconvoluted
Agilent-NISTmAb Intact & Subunit Analysis Using Reversed Phase Agilent BioHPLC Columns Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test…
Klíčová slova
counts, countsmab, mabherceptin, herceptinintact, intactpage, pagecontents, contentsbonds, bondsback, backdeglycosylated, deglycosylateddeconvoluted, deconvolutedmass, massides, idesamu, amubravo, bravoassaymap
Agilent BioHPLC Columns Characterization of NIST Monoclonal Antibody Critical Quality Attributes Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test…
Klíčová slova
mab, mabglycan, glycanadvancebio, advancebiocounts, countsmapping, mappingpeptide, peptideagilent, agilentmonoclonal, monoclonalglycans, glycansmin, mincolumn, columnprotein, proteinmass, massnistmab, nistmabassaymap
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements Application Note Biotherapeutics and Biosimilars Authors Introduction Shuai Wu and Maryann Shen Monoclonal antibody (mAb) based entities represent a rapidly growing class of biologics that require extensive…
Klíčová slova
counts, countsmab, mabherceptin, herceptinbonds, bondsdeglycosylated, deglycosylatedides, idesassaymap, assaymapbravo, bravonist, nistantibody, antibodyintact, intactaffinity, affinitymass, massdeconvoluted, deconvolutedcartridge
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