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A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS

Aplikace | 2020 | Agilent TechnologiesInstrumentace
Příprava vzorků, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Zaměření
Farmaceutická analýza
Výrobce
Agilent Technologies
Klíčová slova
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Profiling Glycosylation of Monoclonal Antibodies at Three Levels Using the Agilent 6545XT AdvanceBio LC/Q‑TOF
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glycan, glycanglycoforms, glycoformsmab, mabnistmab, nistmabquantitation, quantitationintact, intactglycans, glycansagilent, agilentassaymap, assaymapadvancebio, advancebiomapping, mappingbioconfirm, bioconfirmbravo, bravocounts, countsdeconvoluted
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Klíčová slova
counts, countsmab, mabherceptin, herceptinintact, intactpage, pagecontents, contentsbonds, bondsback, backdeglycosylated, deglycosylatedmass, massdeconvoluted, deconvolutedides, idesamu, amubravo, bravoassaymap
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Agilent BioHPLC Columns Characterization of NIST Monoclonal Antibody Critical Quality Attributes Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test…
Klíčová slova
mab, mabglycan, glycanadvancebio, advancebiocounts, countsmapping, mappingpeptide, peptideagilent, agilentmonoclonal, monoclonalglycans, glycansmin, mincolumn, columnprotein, proteinmass, massnistmab, nistmabassaymap
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
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counts, countsmab, mabherceptin, herceptinbonds, bondsdeglycosylated, deglycosylatedides, idesassaymap, assaymapnist, nistbravo, bravoantibody, antibodyintact, intactaffinity, affinitymass, massdeconvoluted, deconvolutedcartridge
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