Plnění požadavků směrnice EU o pitné vodě: klíčová role přípravy vzorků při analýze stopových kontaminantů

Vážení zákazníci a obchodní partneři,rádi bychom vás informovali, že dnešním dnem 12. ledna 2026 nabývá účinnost část Vyhlášky 252/2004 Sb., o hygienických požadavcích na pitnou a teplou vodu a četnost a rozsah kontroly pitné vody, ve znění pozdějších předpisů.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_AI_Rozbory_pitna_voda_ALS_CR_1_b7a65fb299/LabRulez-AI-Rozbory-pitna-voda-(ALS-CR)-1.jpg" alt="LabRulez/AI: Rozbory pitná voda (ALS Čr) " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_AI_Rozbory_pitna_voda_ALS_CR_1_b7a65fb299/thumbnail_LabRulez-AI-Rozbory-pitna-voda-(ALS-CR)-1.jpg 156w," sizes="100vw" width="815" height="815"><h4>Co se mění?</h4>12. ledna 2026 vstoupila v platnost novela Vyhlášky č. 252/2004 Sb., která rozšiřuje seznam chemických ukazatelů v příloze č.1, tabulky B o tyto ukazatele:<ul><li>Řádek 20 - Bisphenol A (BPA): Limitní hodnota 2,5 µg/l</li><li>Řádek 29 - Halogenoctové kyseliny (HAA): Limitní hodnota 60 µg/l (limitní hodnota se vztahuje na součet kvantitativně zjištěných koncentrací kyselin: chloroctová, dichloroctová, trichloroctová, bromoctová a dibromoctová)</li><li>Řádek 52 - Suma PFAS: Limitní hodnota: 0,10 µg/l (suma PFAS zahrnuje: PFBA, PFPA, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFTrDA, PFBS, PFPS, PFHxS, PFHpS, PFOS, PFNS, PFDS, perfluoroundekansulfonová kyselina, perfluorododekansulfonová kyselina, perfluorotridekansulfonová kyselina)</li></ul><blockquote>Podrobné znění vyhlášky naleznete <a target="_blank" rel="noopener noreferrer" href="https://www.zakonyprolidi.cz/cs/2004-252/zneni-20260112">zde</a>.</blockquote><ul><li>Od dnešního dne tedy musí být tyto parametry zahrnuty do pravidelných kontrol pitné vody.</li><li>Laboratoře ALS Czech Republic již nabízí <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/products/991">rozbory pitných vod v plném rozsahu dle této vyhlášky</a>.</li></ul>Kontaktujte nás!Máte dotazy ohledně nových parametrů a požadavků? Potřebujete poradit s implementací?<blockquote>Jsme tu pro vás! Neváhejte nás kontaktovat na e-mailu: info.cz@alsglobal.com nebo na tel.: +420 226 226 228</blockquote>

Nové limity pro testování pitné vody

Ačkoliv moderní zemědělství potřebuje vycházet z přesných dat o půdních, rostlinných i environmentálních podmínkách v reálném čase, cenově dostupná, dostatečně citlivá a zároveň robustní monitorovací zařízení pro tento účel v současné době chybí. Jako vhodné řešení se podle vědců nabízí nízkonákladové senzory založené na nových chytrých materiálech a technologiích tisku. Dosavadní výsledky multiioborového výzkumu i návrhy na vývoj těchto zařízení představili výzkumníci z Česka, Velké Británie, Španělska i USA v přehledovém článku v prestižním časopise <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1">Nature Communications</a>.„Senzorické technologie pro monitorování zdraví rostlin jsou stále v plenkách. Na trhu jsou běžné dostupné jen jednoduché senzory, které jsou schopné monitorovat pouze základní parametry jako například pH, vlhkost v půdě, případně teplotu. Pokud však mají zemědělci čelit současným výzvám včetně klimatických změn a zajistit pro lidstvo dostatek potravy, potřebují mnohem účinnější pomocníky, jež jim umožní monitorovat například i různé patogeny včetně bakterií či plísní. Podle nás je vhodným řešením kombinace nových chytrých materiálů a tisku pro produkci levných, odolných a škálovatelných materiálů,“ uvedl první autor článku David Panáček z CATRIN, který na studii pracoval během své stáže v Imperial College London.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152">Senzory pro monitorování zdraví rostlin například v porovnání s podobnými zařízeními pro humánní medicínu pokulhávají. Klíčovou roli v možném posunu hraje podle autorů pokrok v materiálových vědách, jenž vývoj škálovatelných senzorových technologií umožní. „Tiskové techniky včetně inkoustového tisku, sítotisku, aerosolového tisku, 3D tisku a přímého laserového zápisu nabízejí flexibilní cesty k výrobě ohebných senzorů, senzorů pro velké plochy i senzorů integrovaných přímo do rostlin. Přehledový článek shrnuje nedávný pokrok v oblasti tisknutelných nízkorozměrných materiálů pro zemědělské senzory, analyzuje jejich fyzikálně-chemické vlastnosti ve vztahu k senzorovému výkonu a diskutuje hlavní výzvy a budoucí příležitosti vyžadující mezioborovou integraci,“ uvedl jeden z korespondujících autorů Michal Otyepka.Výzkum propojil materiálové vědce, chemiky, biology, odborníky na senzing i technologie tisku. Materiálový výzkum a využití chytrých materiálů na bázi grafenu zaštítili vědci CATRIN Univerzity Palackého a VŠB-Technické univerzity Ostrava, znalostmi o vývoji rostlin, jejich reakcích na stresové podmínky i monitorování jejich vlastností přispěli rostlinní biologové z CATRIN, o oblast elektroniky se postarali výzkumníci z Imperial College London, technologiím tisku se věnovali zástupci <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/36">CEITEC – VUT</a>. V týmu nechyběli ani přední odborníci na senzing z Katalánského institutu nanověd a nanotechnologií v Barceloně a svými bohatými znalostmi přispěl i „otec senzingu a elektrochemie“ Joseph Wang z University of California San Diego.„Jedná se o průlomovou studii na toto téma, k níž se podařilo přizvat skutečně velká jména v daných oborech. V neposlední řadě studie dokládá to, že interdisciplinarita v CATRIN dává vzniknout zcela novým a perspektivním výzkumným tématům, jako je rostlinný senzing a jeho využití pro studium interakce rostlin s prostředím a chytrém zemědělství,“ doplnila další z korespondenčních autorů Nuria De Diego. &nbsp;

Současné senzory nestačí. Vědci navrhují novou cestu ke sledování zdraví rostlin

Životní prostředí

Vody

Vědecký článek

Věda a výzkum

Video

Článek

Laboratoře

Základním posláním společnosti ALS je pomáhat našim klientům se kvalifikovaně a informovaně rozhodovat tím, že poskytuje spolehlivá, konzistentní a reprodukovatelná laboratorní data. Zaručujeme spolehlivé výsledky, krátké dodací lhůty, nepřetržitý provoz, odbornou podporu a odběry vzorků.

ALS Czech Republic

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Společnost Organomation, založená v roce 1959, navrhuje a vyrábí vysoce kvalitní dusíkové koncentrátory a extrakční systémy. Jejich laboratorní přístroje, známé svou inovativností a odolností, se používají po celém světě pro efektivní přípravu vzorků a jsou doprovázeny silnou zákaznickou podporou.

Organomation

Agilent Technologies

Technology Networks

Bruker

Thermo Fisher Scientific

Wiley

SCIEX

Evosep Biosystems

Waters Corporation

Unlock new perspectives with our accurate mass 101 webinar series.
Accelerate your workflows and expand your knowledge around accurate mass with these informative webinars.
In this webinar series, SCIEX applications scientists will explain the benefits of using accurate mass, sample analysis, instrument operation and data processing in real-time.
Get the inside scoop and register today!
<h3>Accurate mass 101: non-targeted analysis</h3>
Join us for this webinar to see how to discover the unknown using non-targeted analysis. We will showcase workflows and strategies to drive success with suspect screening and non-target identification. Discover the ability to identify peaks of interest and confidently identify unknown compounds.

SCIEX: Accurate mass 101: non-targeted analysis

Accurate mass 101: non-targeted analysis

SCIEX applications scientists will explain the benefits of using accurate mass, sample analysis, instrument operation and data processing in real-time.

LC-MS/MS is rapidly becoming the gold standard for quantifying different classes of analytes in endocrinology research. The power of greater selectivity and analytical sensitivity using LC-MS/MS is critical in understanding the status of endocrine biochemical pathways. The enhanced performance observed on these platforms provides increased confidence in the results, enabling you to make better decisions based on more accurate information.
Greater analytical sensitivity is a goal that drives improvements in precision, leading to clearer insights into results down to low physiological concentrations. Here we will discuss the latest introduction to the Waters MassTrak™ IVD system family, which is shown to be analytically sensitive and efficient, helping to reduce cost and improve the quality of your data. 
Learning objectives: 
<ul>
<li>An introduction to the latest addition to Waters MassTrak IVD System for clinical laboratories
</li>
<li>The importance of selectivity in endocrinology research in obtaining high quality data
</li>
<li>How the latest addition to Waters MassTrak IVD System addresses the needs of those key endocrinology research applications, including steroid hormone analysis
</li>
</ul>
<blockquote>
Presenter: Dominic Foley (Principal Scientist, Waters Corporation)
</blockquote>
<blockquote>
Dominic is a Principal Scientist working at Waters Mass Spectrometry Headquarters in Wilmslow, UK. Having joined the company in September 2013, he has specialized in the development of LC-MS/MS clinical research applications, with expertise in steroid hormone analysis and protein/peptide quantification. In his role, he also collaborates with clinical customers in the development and implementation of LC-MS/MS methods in their laboratories.
</blockquote>
<blockquote>
Dominic has worked in separation sciences for 14 years, following his ambition of improving the quality of healthcare. He started his career with ICON Development Solutions, a CRO in the north of the UK, where he worked as a LC-MS/MS method development and validation scientist supporting DMPK studies in drug discovery. In 2012, he joined Thermo Fisher Scientific to work in their Chromatography R&amp;D team as a Technical Support Specialist, working on the development of new chromatography and sample preparation products.
</blockquote>
<blockquote>
Dominic received his BSc (Hons) in Biochemistry from the University of Manchester in 2006. He has presented his work at conferences around the world and has several publications in both the Microchemical Journal and the Journal of Chromatography A.
</blockquote>
<blockquote>
Presenter: David Ballantyne (Principal Product Manager, Waters Corporation)
</blockquote>
<blockquote>
David Ballantyne is a Principal Product Manager at Waters Corporation, working within the Global Clinical Diagnostics Portfolio Management team. Having joined the company in 2005, he has held multiple roles throughout Manufacturing and R&amp;D. David has a background in Electrical and Mechanical Engineering and began his career at Waters supporting GC-MS/MS technologies including Tandem Quadrupole and Magnetic Sector Mass Spectrometry.
</blockquote>
<blockquote>
In 2018 he moved to his role in Product Management where is focus changed to Clinical Diagnostics, with a particular focus on LC – MS/MS Instrumentation and Informatics solutions. Over the last 5 years David has spent much of his time focused on understanding customer problems and translating them into new solutions.
</blockquote>

Waters Corporation: The Evolving Power of LC-MS/MS Technology within Endocrinology

The Evolving Power of LC-MS/MS Technology within Endocrinology

Here we will discuss the latest introduction to the Waters MassTrak™ IVD system family for clinical laboratories.

The Evolving Power of LC-MS/MS within Endocrinology

Dear user and other PaSER interested customers,
You are hereby invited to our 2nd Virtual PaSER Workshop. A lot of new possibilities has been introduced since last time – including, but not limited to PaSER Novor for de novo sequencing of dda-PASEF® data on the PaSER Box as well as TIMS DIA-NN 2.0 -which will be demonstrated during this Workshop. Data virtualization has been a requested feature – and this is now possible with Mass Dynamics for PaSER. Not limited to above – stay tuned for even more approaching features, we will discuss as well.
<h3>The tentative agenda looks like this:</h3>
<h5>1:00 – 1:15 pm: Introduction</h5>
<ul>
<li>Willy Bjørklund</li>
</ul>
<h5>1:15 – 1: 35pm: New Applications on the timsTOF Platform</h5>
<ul>
<li>Lars Kristensen (Field Application Specialist)</li>
</ul>
<h5>1:35 – 1:55 pm: PaSER as a bioinformatic platform - what’s new and what’s coming</h5>
<ul>
<li>Jonathan Krieger (Software R&amp;D Department)</li>
</ul>
<h5>5 minute break</h5>
<h5>2:00 – 2:20 pm: Live Demo/workshop of PaSER</h5>
<ul>
<li>Tharan Srikumar (Software R&amp;D Department)</li>
</ul>
<h5>2:20 – 2:50 pm: Mass Dynamics</h5>
<ul>
<li>Mark Condina and Giuseppe Infusini</li>
</ul>
<h5>2:50 – 3:10 pm: Questions and discussions</h5>
<h5>3:10 – 3:15 pm: Conclusion</h5>
<ul>
<li>Willy Bjørklund</li>
</ul>
We aim for a lively interaction so take the timing as an indication. Please feel free to share with colleagues or others you think could benefit from attending this workshop. Looking forward to “meet”

Bruker Virtual PaSER Workshop

Dear user and other PaSER interested customers, You are hereby invited to our 2nd Virtual PaSER Workshop. 

This webinar will focus on untargeted LC/MS Omics solutions that will provide the biological insights needed to produce meaningful results. An emphasis will be spent on an End-to-End HILIC metabolomics workflow for our LC/Q-TOF platform.
This includes automate sample preparation for cells and plasma, a Bio LC that is fit for purpose for metal sensitive analysis, robust and transferable HILIC chromatography, the 6546 LC/Q-TOF data independent analysis of samples, with an ID workflow that includes a new HILIC PCDL with 500 core metabolism analytes with spectra and retention time annotation.
For unknowns not found in Agilent PCDLs, SIRIUS/CSI:FingerID which uses AI predict structure from spectra and conducts online identification search will be demonstrated. A complementary targeted multi-omics workflow will be briefly mentioned before sharing the new Ion Mobility and ExD technologies for high end LC/MS Omics investigations.
<blockquote>
Presenter: Karen E. Yannell (Omics Workflow Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Karen E. Yannell is an Omics Workflow Specialist at Agilent Technologies. She is an expert in small molecule high throughput analysis by triple quadrupole (TQ) and quadrupole time-of-flight (Q-TOF) mass spectrometry for applied markets. Her recent work has focused on developing targeted metabolomics methods and routine Q-TOF workflows for both expert and non-expert users alike. Previously, Karen worked on forensic, metabolomics, and biomarker discovery applications with ambient ionization sources. She received her PhD in Analytical Chemistry from Purdue University where studied under the advisement of Prof. R. Graham Cooks. 
</blockquote>
<blockquote>
Presenter: Dr. Martin Graf-Utzmann (Editor, Wiley Analytical Science, Moderator)
</blockquote>
<blockquote>
Dr. Martin Graf-Utzmann has a Ph.D. in Theoretical Chemistry and is an editor for Wiley Analytical Science. His interests are mainly Laboratory Automation, Digitalization, and Lab Equipment.
</blockquote>

Wiley Analytical Science: Jump Start Your LC/Q-TOF Omics Investigation with Reliable Workflows

Jump Start Your LC/Q-TOF Omics Investigation with Reliable Workflows

This webinar will focus on untargeted LC/MS Omics solutions that will provide the biological insights needed to produce meaningful results.

Your LC/Q-TOF Omics Investigation with Reliable Workflows

This year we invite you to ignite your mind to Be Curious about what Ion chromatography (IC) can do with its versatility in many detections across the IC application spectrum to improve your workflows and solve challenges.
During this three day virtual event, learn from a panel of experts how the latest IC applications are helping colleagues achieve breakthroughs, and walk away with valuable information on how advancements in IC can increase laboratory analytical capabilities. 
Although each day is convenient for a specific region, you can attend any session on any day. All sessions and workshops will be available for on-demand viewing after the event concludes.
<h3>Day 1 Agenda | April 18 | North and South America</h3>
Discover IC column development, and where it’s headed with mass spectrometry, as they can be an integral detection for carbohydrate profiling and environmental metabolites characterization. Learn how standalone IC can solve industrial samples and degradation products with comprehensive IC information, all at once.
<h5>11:30 EDT: Opening Plenary: The Past, Present, and Future of IC Column Development</h5>
<ul>
<li>Alexandra Zatirakha (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
</ul>
<h5>12:30 EDT: Characterizing Carbohydrate Degradation Products from Bacteroides Thetaiotaomicron to Understand Bacterial Dextran Utilization in the Gut</h5>
<ul>
<li>Neil Rumachik (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
<li>Fiona Cuskin (Newcastle University, UK)</li>
</ul>
<h5>1:30 PM EDT: Toward Comprehensive Chemical Characterization of Metabolomic Using Orbitrap Fusion Tribrid Mass Spectrometer Coupled with Ion and Liquid Chromatography Techniques: Dissolved Organic Matter as an Example</h5>
<ul>
<li>Hussain Abdulla (Department of Physical and Environmental Sciences, Texas A&amp;M University-Corpus Christi)</li>
</ul>
<h5>2:30 PM EDT: The Use of Ion Chromatography in the Monitoring of Degradation Products from the Electrochemical Treatment Of Organic Compounds</h5>
<ul>
<li>Emily Tossi (Federal University of Rio Grande do Norte)</li>
</ul>
<h5>3:30 PM EDT: Ion Chromatography as a Tool for Industrial Problem Solving</h5>
<ul>
<li>Isaac Negrete and Stephen Fosdick (Dow)</li>
</ul>
<h5>4:30 PM EDT: Workshop: Everything, Everywhere, All at Once IC!</h5>
<ul>
<li>Kelly Femrite (IC/SP Product Support, Sunnyvale)</li>
<li>Carl Fisher (IC/SP Product Marketing, Sunnyvale)</li>
<li>Criss Corchard-Keeler (Service Marketing Manager, CMD/MOL Thermo Fisher Scientific)</li>
</ul>

Thermo Fisher Scientific: IC Symposium 2023

IC Symposium 2023 - Day 1

Join us for the 2023 Global IC Symposium! North and South America

This year we invite you to ignite your mind to Be Curious about what Ion chromatography (IC) can do with its versatility in many detections across the IC application spectrum to improve your workflows and solve challenges.
During this three day virtual event, learn from a panel of experts how the latest IC applications are helping colleagues achieve breakthroughs, and walk away with valuable information on how advancements in IC can increase laboratory analytical capabilities. 
Although each day is convenient for a specific region, you can attend any session on any day. All sessions and workshops will be available for on-demand viewing after the event concludes.
<h3>Day 3 Agenda | April 20 | Asia Pacific</h3>
Expand the world of electrochemistry applications and IC hyphenation with high-resolution mass spectrometry and understand how Inductively Coupled Plasma Spectrometry can speciate isotopes while simplifying Pharmacopeia QC analysis and keeping your IC in top-notch condition.
<h5>11:00 AM SGT: Opening Plenary: Electrochemical Detection and Its Application in Ion Chromatography</h5>
<ul>
<li>Yan Liu (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
</ul>
<h5>12:00 PM SGT: Application of Anion Chromatography Coupled High-Resolution Mass Spectrometry to Increase Cellular Metabolite Coverage</h5>
<ul>
<li>Vinzenz Hofferek (McConville Lab, Department of Biochemistry and Pharmacology)</li>
</ul>
<h5>1:00 PM SGT: Analysis of Anhydrosugars and Xylooligosaccharides by Ion Chromatography with Electrospray Lithium Cationisation-Triple Quadrupole Tandem Mass Spectrometry</h5>
<ul>
<li>Dr. Estrella Sanz Rodriguez (Natural Products Analysis, Australian Centre for Research on Separation Science (ACROSS), University of Tasmania)</li>
</ul>
<h5>2:00 PM SGT: You Gotta Keep ‘Em Separated: Novel IC Applications for Subsequent Isotopic Analyses by Rapid and/or Hyphenated Techniques</h5>
<ul>
<li>Dr. Brandon Mahan (College of Science and Engineering, James Cook University)</li>
<li>Grace Manestar (IsoTropics PhD Candidate)</li>
</ul>
<h5>3:00 PM SGT: Use of Ion Chromatography in Pharmaceutical Quality Control</h5>
<ul>
<li>Catherine Frankis and Stella Planou (Reading Scientific Services Ltd., Reading Science Centre, Whiteknights Campus)</li>
</ul>
<h5>4:00 PM SGT: Tips on Keeping Your Ion Chromatography in Top-Notch Condition</h5>
<ul>
<li>Ryan Ong (Thermo Fisher Scientific, IC/SP Application Sales Support, Singapore)</li>
</ul>

IC Symposium 2023 - Day 3

Join us for the 2023 Global IC Symposium! Day 3 | Asia Pacific.

The CRISPR/Cas system has been increasingly used as a genome editing tool with applications that include disease treatment. The safety and efficacy of these genetic medicines depend on the stability and purity of each molecular component, which can be assessed and characterized by numerous analytical techniques.
Biopharma 101 is intended to give you an introduction to analytical workflows for specific therapeutic modalities. In this webinar, our expert speakers will focus on various gene editing systems and how you can utilize analytical instrumentation to characterize the various components. 
<h5>Attend this webinar to learn how to:</h5>
<ul>
<li>Characterize an engineered Cas9 protein, its amino acid mutations and post-translational modifications using LC-MS/MS</li>
<li>Evaluate purity and sizing of CRISPR systems with capillary gel electrophoresis (CGE) to overcome technical challenges and minimize impacts of higher-order structure</li>
<li>Determine RNA integrity and purity, critical to ensuring the efficacy of RNA-based therapeutics and vaccines</li>
<li>Understand plasmid quality with capillary gel electrophoresis laser-induced fluorescence (CGE-LIF)</li>
</ul>
<blockquote>
Presenter: Paula Orens (Market Development Manager, SCIEX)
</blockquote>
<blockquote>
Presenter: Steven Calciano (Business Development Manager, SCIEX)
</blockquote>

SCIEX: Biopharma 101: Analysis of CRISPR Gene Editing Systems

Biopharma 101: Analysis of CRISPR Gene Editing Systems

We will focus on various gene editing systems and how you can utilize analytical instrumentation to characterize the various components. 

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
An easy to follow guide detailing how to set MS scan parameters for an LCMS experiment will be presented. Scan speeds for reproducible quantitation, chromatographic resolution, retention time definition, proper threshold adjustment for optimum datafile size, and how this can result in faster processing times will all be discussed.
<blockquote>
Presenter: Rebecca Glaskin, Ph.D. (LC/MS Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rebecca Glaskin is an LC/MS Application Scientist at Agilent with a focus on BioPharma applications supporting the LC-Q/TOF and IM-QTOF platforms. Prior to joining Agilent, Rebecca received her Ph.D. in analytical chemistry from Indiana University in the lab of Professor David Clemmer. While there she designed and constructed home-built instruments, pushing the limits of the mobility resolution that can be obtained with a circular drift tube for the separation of biomolecules (peptides, proteins, carbohydrates, and metabolites). While there, she also studied hydrogen/deuterium exchange of proteins in the gas-phase as a function of time and pressure. Rebecca then went to Boston University as a Postdoctoral Associate in the lab of Professor Catherine Costello to develop a database containing collision cross section values for glycans, peptides, and glycopeptides utilizing Agilent Technologies 6560 IM-QTOF. This database can be used to determine how the collision cross section is altered with the addition of individual saccharide units. The trendlines obtained from this database will be used to predict collision cross sections for glycopeptides based on the conformation and structure of the specific glycoform.
</blockquote>
<blockquote>
Presenter: Jim Lau, PhD (HRAMS LC/MS Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Jim Lau received his Ph.D. From the University of Colorado. There he worked in the laboratories of Peter Albersheim and Robert Shapiro. This work involved the structure elucidation of plant natural products and, in particular, elucidating the structures of oligosaccharides derived from plant cell wall polysaccharides. This work was done in the early days of LCMS and made use of DLI-LCMS and (at the time) recently invented Thermospray-LCMS.
</blockquote>
<blockquote>
After the completion of his Ph.D., Jim joined Hewlett-Packard to work on LCMS ionization techniques with Paul Goodley during the early days of Electrospray-LCMS. He then moved to work on field applications and collaborations with Hewlett-Packard’s LCMS customers. More than 30 years later, Jim continues to work with Agilent’s customers in High Resolution Accurate Mass applications of LCMS. While involved in many areas of HRAMS LCMS, his recent work has focused on the area of Screening/Qual&amp;Quant of small molecules and on the high throughput confirmation of oligonucleotide synthesis.
</blockquote>

Agilent Technologies: How to set MS Scan Parameters for your LCMS Experiment

How to set MS Scan Parameters for your LCMS Experiment

An easy to follow guide detailing how to set MS scan parameters for an LCMS experiment will be presented.

Targeted workflows are particularly interesting for identifying established biomarkers in various applications. The focus on these workflows, coupled with technological advancements, is continually expanding the boundaries of high-throughput targeted analysis.
<h3>Next Generation of absolute protein Quantitation in Biological Matrixes; higher multiplexicity while faster, robust and sensitive</h3>
<ul>
<li>Presenter: Dr. Christoph Borchers (Mcgill university)</li>
</ul>
The accurate and rapid determination of protein concentrations using multiplexed multiple reaction monitoring (MRM) with isotope-labeled internal standards has the potential to revolutionize biochemistry and medical sciences. The combination of an Evosep One LC with an Agilent QQQ6495C allows a several-fold reduction of analysis time while maintaining high multiplexicity. As an example, we show the use of a multi-protein method for the absolute quantitation of 270 proteins, combined with metabolomics and Artificial Intelligence (AI), to analyze the plasma of a COVID cohort for prediction of survival. Moreover, optimization of the Evosep/6495C combination allowed adaptation of the 270-protein MRM method to a 24-minute gradient, thus doubling the throughput compared to before.
<h3>Development of a LC-MS/MS Method for Measurement of Fusion Sarcoma Proteins in Plasma</h3>
<ul>
<li>Presenter: Phd. AnThony Maus (Clinical Mass Spec. Development Laboratory, Mayo Clinic)</li>
</ul>
Sarcoma is general term for a group of over 70 cancers that are classified using genomic techniques to identify characteristic gene fusions in tumor tissues. However, this technique requires relatively invasive biopsies and is not conducive to monitoring disease progression or response to treatment. Measurements of fusion protein biomarkers in plasma would overcome these limitations. We sought to develop an LC-MS/MS method capable of performing these measurements by conducting discovery experiments on cell lines with an EvoSep coupled to an Exploris 480 mass spectrometer. Using these data, we developed a targeted method and performed measurements in plasma samples.

Targeted Workflows

Targeted workflows are particularly interesting for identifying established biomarkers in various applications.

Targeted LC/MS Workflows

Webinar in collaboration with the Polish Society of Metabolomics.
<h3>14:00 - 14:20 Benefits of Trapped Ion Mobility Spectrometry (TIMS) for Metabolomics and Lipidomics</h3>
<ul>
<li>Presenter: Dr. Stefanie Wernisch ( Business Development Manager Metabolomics/Multiomics, Bruker Daltonics Bremen, Germany)</li>
</ul>
After revolutionizing the area of proteomics, trapped ion mobility spectrometry (TIMS) is now conquering the fields of metabolomics and lipidomics. Bruker&#39;s unique timsTOF technology addresses the complexity of biological samples by adding an orthogonal dimension of separation before mass spectrometric analysis, thus reducing the complexity of MS/MS data and improving annotation confidence for untargeted analysis. The ability to determine Collisional Cross Sections (CCS) can further aid identification and outlier detection in lipidomics studies.
<h3>14:20 - 14:40 SpatialOMx® for in-depth 4D-Lipidomics™</h3>
<ul>
<li>Presenter: Dr. Janina Oetjen (Application Specialist MALDI Imaging, Bruker Daltonics Bremen, Germany)</li>
</ul>
The combined possibilities of ESI and MALDI in one instrument enables powerful SpatialOMx® applications. In short, ion mobility-based annotation can connect confident LC-TIMS-MS/MS identification with meaningful spatial information from MALDI Imaging, specifically in the field of lipidomics. Further, segmentation results based on lipid imaging can define specific regions of interest for subsequent, in-depth analysis. Thus, the information content of MALDI Imaging can be enhanced with SpatialOMx® workflows on the timsTOF fleX platform.
<h3>14:40 - 15:00 Application Round-up: 4D-Metabolomics™ and 4D-Lipidomics™</h3>
<ul>
<li>Presenter: Dr. Matthias Szesny (Application Scientist Metabolomics, Bruker Daltonics Bremen, Germany)</li>
</ul>
We will highlight the capabilities of the timsTOF platform and introduce new applications, method developments, and software solutions in the field of metabolomics and lipidomics. Those help scientists gain a faster and deeper understanding of diverse research areas such as health and disease as well as agriculture.

Bruker: Expanding the Horizons of 4D-Metabolomics and 4D-Lipidomics

Expanding the Horizons of 4D-Metabolomics and 4D-Lipidomics

Benefits of TIMS for Metabolomics and Lipidomics. SpatialOMx for in-depth 4D-Lipidomics, Application Round-up: 4D-Metabolomics and 4D-Lipidomics.

LCMS webináře se zaměřením na LC/MS/MS - strana 60