Data‑Driven Upstream Control: Optimizing Cell Media Analysis and Titer Assessment

Optimize Upstream Control with Data‑Driven Cell Media Analysis & Titer Assessment

This session explores how advanced analytics enable tighter control of upstream bioprocesses. We begin with a walkthrough of recent work in cell culture media analysis, highlighting vitamin profiling as a tool to better understand nutrient utilization and process performance.

The story continues with focus on optimizing titer measurement using analytical Protein A, demonstrating benefits such as higher sensitivity for measurement earlier in cell cultures, faster results, improved data quality, and reduced workflow complexity to support more informed, timely upstream decision‑making.

Key takeaways:

• Understand how advanced cell media analysis, including vitamin profiling, enhances understanding of nutrient utilization and upstream process performance.
• Evaluate how analytical Protein A titer measurements enable earlier, faster, and more sensitive assessment of product formation during cell culture.
• Apply data‑driven analytical insights to improve upstream process control, data quality, and decision‑making efficiency.

This Webinar is designed for:

• Upstream Process Development & Engineering Teams – Scientists and engineers focused on media optimization, nutrient utilization, and improved process control.
• MSAT & Process Characterization Professionals – Teams seeking deeper process understanding and data‑driven decision making across development and manufacturing.
• Analytical Development Scientists – Experts responsible for cell media and titer analysis who want faster, more sensitive, and streamlined analytical workflows.

Speaker: Mark Wrona (Consulting Scientist, Biologics Business Unit, Waters Corporation)

Mark Wrona manages specialized teams of scientists developing analytical applications to support drug development and PAT applications.

He specializes in biologics and life sciences applications.He has 15 years with Waters and prior experience as a research chemist at a large pharma.

Speaker: Fang Lu (Senior Upstream Process Development Scientist, Waters Corporation)

Dr. Fang Lu is a Senior Upstream Process Development Scientist at Immerse Delaware, Waters Corporation.

She has expertise in viral vector upstream process development, gene therapy manufacturing, and monoclonal antibody upstream development, with a focus on applying analytical tools to enhance process understanding and optimization.

Prior to joining Waters, Fang spent four years in the cell and gene therapy CDMO industry supporting process development for complex biologics and advanced therapy applications.