ProteinTurnoverAtlas™: A Resource for Modern Drug Discovery

Understanding how quickly proteins are renewed in cells is fundamental for maintaining proteostasis and for the successful development of modern protein targeting medicines such as PROTACs, covalent inhibitors, and molecular glues. This webinar will introduce the ProteinTurnoverAtlas™ a comprehensive resource generated with the TurnoverScout™ platform that combines pulsed SILAC labeling, high coverage LC-MS/MS and rigorous kinetic modeling. 

The atlas currently provides protein half-lives for more than fifteen thousand proteins across approximately fifty cellular systems, including primary cells, iPSC derived neurons and a broad range of cancer models. In addition, we will introduce a complementary MouseTurnoverAtlas™ offered as a dedicated in vivo resource across multiple organs and biofluids, which extends the ProteinTurnoverAtlas™ concept beyond cell systems and provides a physiological frame of reference for interpreting protein stability in cellular models.

We will outline the experimental design and data processing workflow, highlight quality control criteria and benchmarks against published datasets, and share case studies where baseline turnover directly informed target selection, compound design, and dosing strategies. Attendees will gain practical guidance on how to query and interpret turnover data for their own projects and integrate it with other proteomics and genomic readouts.

Learning points

• Understand how the Protein Turnover Atlas is generated, from pulsed SILAC labeling and LC-MS/MS measurement to kinetic modeling and assignment of confidence classes for protein half lives
• See how baseline protein turnover information can be applied in drug discovery, for example to support target selection, modality choice for degraders and covalent inhibitors, and the design of cellular assays and dosing schemes
• Take away concrete ideas for how to enhance your own drug discovery workflows and decision-making with protein turnover information and the Protein Turnover Atlas

Who should attend?

• Scientists in drug discovery who work with PROTACs, molecular glues or covalent inhibitors and want to understand their targets in a proteome wide context
• Proteomics and mass spectrometry specialists interested in implementing pSILAC based turnover studies or in benchmarking their own datasets against a large reference atlas
• Project leaders and portfolio managers who need intuitive guidance on how protein half-life impacts development timelines, dosing concepts, and biomarker strategies

If you cannot attend this webinar please register to receive a link to the On Demand version the following day.

Presenter: Christin Zasada (Head of Bioinformatics, OmicScouts (a Momentum company))

Presenter: Götz Hagemann (Head of Chemical Biology and Biochemistry, OmicScouts (a Momentum company))