Overcoming LC Analytical Challenges in Small Molecule Kinase Inhibitor Development

Currently there are over 80 FDA approved kinase inhibitors across several sub-types. Each kinase inhibitor can present its own unique challenges based on the molecular structure and functional groups present, however some of the challenges associated with these compounds is common across the entire class. 

This webinar will look at existing solutions to the development and characterization of kinase inhibitors with examples of purifying them from biological fluids, improving analyte recovery and detection, and finally allowing for high-resolution MS detection by eliminating complex mobile phase additives.

Presenter: Kenneth D. Berthelette (Principal Scientist, Chemistry Research and Development, Waters Corporation)

Ken earned his Bachelor of Science degree in Professional Chemistry from Bridgewater State University in Bridgewater, Massachusetts, in 2010. He has been with Waters Corporation since March 2012 and has contributed to several product launches, including CORTECS columns, UPC² Torus and Trefoil columns, and the Atlantis Premier BEH Z-HILIC column. In 2021, he transitioned to supporting Chemistry Aftermarket initiatives such as Indomitable. Ken’s focus on applications and customer education has led to numerous seminars and webinars on topics including method development, modernization and transfer, and HILIC separation techniques.