Lipid Imaging Mass Spectrometry and Multi-Omics Integration
Discover the Future of Lipid Imaging and Multi-Omics Integration
We’re excited to partner with the University of Pittsburgh to bring you an exclusive webinar with Dr. Brian Hoffmann from The Jackson Laboratory. Join us as we introduce cutting-edge technologies which combine highly-sensitive LC-MS and spatial mass spectrometry imaging (MSI) capabilities to offer new possibilities for metabolomics and lipidomics research.
Following an introduction to the timsTOF fleX by the Bruker application team, Dr. Hoffmann will present on how he utilizes traditional LC-MS with MSI at the Jackson Laboratory to target physiological changes across numerous systems. His research integrates lipidomics, metabolomics, and proteomic analyses down to the single cell level to identify specific changes in aging and Alzheimer’s Disease.
Within these studies, Dr. Hoffmann utilizes MSI (down to 5 micron resolution) on the timsTOF fleX platform to characterize the spatial distribution of diverse molecular classes, with a focus on lipidomics, to reveal critical relationships that drive aging and neurodegenerative processes. As the spatial lipid distribution defines the physiology of the brain across conditions in these studies, he utilizes the MSI lipidomics data to further determine specific regions of interest to follow-up with complementary multi-omics analyses.
Key Learning Objectives:
- Introduce Mass Spectrometry Imaging (MSI)
- Understand the value in combining spatial MSI with traditional bulk LC-MS data
- Explore ways researchers leverage multi-omics studies on the timsTOF fleX to draw new insights from complex disease and biological systems
Who should attend?
- Scientists and researchers interested in expanding their metabolomics and lipidomics workflows to the spatial dimension
- Those interested in multi-omics and next-generation mass spectrometry applications
- Anyone interested in learning more about Mass Spectrometry Imaging
Don’t miss this opportunity to gain expert insights and stay ahead in the field of multi-omics research.
Presenter: Brian R. Hoffmann, Ph.D. (Director of Protein Sciences and Mass Spectrometry Services, The Jackson Laboratory, Bar Harbor, ME, USA)
Brian Hoffmann, Ph.D., is the Director of Protein Sciences and Mass Spectrometry Services at The Jackson Laboratory. He obtained his doctorate degree from the University of Wisconsin-Madison in Molecular and Cellular Pharmacology, with a focus on protein interactions and modifications in the extracellular matrix. During this time he also received formal and informal mass spectrometry training on a variety of mass spectrometry instruments. This training was then furthered through a postdoctoral position at the Medical College of Wisconsin in stem cell physiology and proteomics. While at the Medical College of Wisconsin he received a NIH NIDDK K01 grant related to the influence of hyperglycemia on the cardiovascular system and transitioned to an Assistant Professor position in the Department of Biomedical Engineering.
In late 2020, he was recruited to The Jackson Laboratory as a Scientist to build up the mass spectrometry capabilities and has since transitioned to his current position managing the Mass Spectrometry Service. In his laboratory the team utilizes multi-omics mass spectrometry-based approaches for molecular phenotyping of a variety of models.
