Automation Strategies for Bioanalytical Method Development with Oasis HLB

Bioanalytical solid-phase extraction (SPE) method development often struggles with recovery variability, complex workflows, and the pressure to deliver robust results on tight timelines. This webinar will share how Waters’ Oasis HLB SPE protocols can be optimized to simplify wash/elution conditions to ensure high recovery and cleanliness across diverse analytes using a strategic approach. We will demonstrate how automating these workflows with the Andrew+ Robot reduces manual variability, saves analyst time, and accelerates protocol optimization. Application examples on high-value therapeutics nearing patent expiration, such as Palbociclib and Sitagliptin, will be highlighted.

• Identify practical strategies to overcome recovery variability, matrix effects issues, and development complexity in SPE workflows.
• Learn how to streamline Oasis HLB SPE method development using the 20 Bottle Optimization approach for best-fit SPE protocols across a variety of molecule types.
• See how automation with Andrew+ Pipetting Robot and OneLab Software simplifies SPE method execution, reduces manual variability, and accelerates development timelines.
• Demonstrate robust SPE protocol performance across diverse analytes using real-world applications on high-value therapeutics nearing patent expiration (e.g., Palbociclib, Sitagliptin).

Presenter: Chelsea Plummer, PhD (Principal Product Marketing Manager, Waters Corporation)

Chelsea Plummer, PhD, is a Principal Product Marketing Manager at Waters Corporation with a background in bioanalytical mass spectrometry, specializing in small molecule and peptide analysis. At Waters for 9 years, she is now part of the sample preparation and automation team, leading product initiatives focused on solid-phase extraction (SPE) workflows to support pharmaceutical, food, and environmental applications. Chelsea is passionate about delivering solutions that help scientists achieve high-quality, reproducible results across complex sample matrices.

Presenter: Maggie Christian (Principal Chemistry Market Development Manager, Waters Corporation)

Maggie Christian holds a BS in Analytical Chemistry from Colorado State University and an MBA from Vlerick Business School. With over 15 years of industry experience, she brings a strategic, customer-focused approach to her work. Maggie began her career at Waters as an instrument sales representative before transitioning into a business development role, where she forges cross-industry partnerships, raises awareness of innovative techniques, and supports clients with deep product knowledge and a passion for impactful solutions.