Advanced Agilent QTOF Acquisition Utilities

The Agilent QTOF’s have several utilities that increase the efficiency of the AutoMSMS experiment for small molecules. These utilities enhance the selectivity of the AutoMSMS experiment and dramatically increase the duty cycle for MSMS precursors of interest. The use of QRAI and the novel application of the Agilent Preferred List with Mass Defect guided acquisition will be discussed.

Presenter: Jim Lau, Ph.D. (HRAMS LCMS Application Engineer, Agilent Technologies, Inc.)

Jim Lau received his Ph.D. From the University of Colorado. There he worked in the laboratories of Peter Albersheim and Robert Shapiro. This work involved the structure elucidation of plant natural products and, in particular, elucidating the structures of oligosaccharides derived from plant cell wall polysaccharides. This work was done in the early days of LCMS and made use of DLI-LCMS and (at the time) recently invented Thermospray-LCMS.
After the completion of his Ph.D., Jim joined Hewlett-Packard to work on LCMS ionization techniques with Paul Goodley during the early days of Electrospray-LCMS. He then moved to work on field applications and collaborations with Hewlett-Packard’s LCMS customers. More than 30 years later, Jim continues to work with Agilent’s customers in High Resolution Accurate Mass applications of LCMS. While involved in many areas of HRAMS LC/MS, his recent work has focused on the area of Screening/Qual&Quant of small molecules and on the high throughput confirmation of oligonucleotide synthesis.