Revolutionizing High Resolution Mass Spectrometry and Forensic Toxicology: Key Updates and Solutions

High-resolution mass spectrometry (HRMS) has become the technique of choice for screening applications in forensic and doping laboratories. The Forensic Toxicology Screening Application Solution from Waters was first released in 2015 and has continued to evolve over the years; the current system comprises an ACQUITY UPLC I-Class and Xevo G3 QTof Mass Spectrometer together with a dedicated application package for forensic toxicology and brings the power of high resolution and accurate mass data to the routine laboratory.

The current solution is powered by an application-based software package, waters_connect which provides a single platform for LC and LC-MS applications that accelerates end-to-end scientific workflows, realizing new standards of usability, scientific outcome and compliance.

In addition to the current solution with the Xevo G3 QTof, Waters have recently launched the Xevo MRT, an ultra-high resolution mass spectrometer, achieving mass resolution of up to 100K and mass accuracies typically less than 500 parts-per-billion. With the introduction of this new technology into the forensic and toxicology arena, it has the capabilities to change the way we view mass accuracy for targeted analysis, providing even more assurance when reporting results, but also the extra confidence when performing discovery type analysis, in search of novel psychoactive substances.

Key learning objectives:

• Learn about the development and advancement of the Waters Forensic Screening Application Solution.
• Recognize the benefits of using a single platform for improved usability, scientific outcomes and compliance.
• Assess the significance of Xevo MRT’s ultra-high resolution and mass accuracy in forensic and toxicology applications.

For Forensic Toxicology Use only.

Presenter: Nayan Mistry (Senior Clinical Application Scientist, Forensic Toxicology, Research & Development, Waters Corporation)

Nayan Mistry is a Senior Application Scientist at Waters Corporation. Nayan joined Waters in 2009 and is part of a global team dedicated to performing research and development of applications and analytical solutions for Forensic Toxicology.

Nayan’s key focus is on toxicology screening and he has expertise with both nominal mass and accurate mass-based screening using UNIFI and Waters_Connect application software. Nayan plays a key role in the development of these solutions and in the expansion of associated libraries. Currently Nayan is playing a key role in the development and support of the recently launched Xevo G3 QTof mass spectrometer in addition to other responsibilities for the nominal mass applications. His favourite aspect of the role is customer support - Nayan is greatly involved in global on-site customer support and training and has presented his work at conferences worldwide.