Rapid, robust and reproducible host cell protein analysis with Evosep One
Uncover the power of precision in biopharmaceutical development with our upcoming webinar on Host Cell Protein (HCP) analysis. Join us to explore how Evosep’s technology is enabling researchers to meet stringent regulatory requirements by delivering reliable, high-sensitivity data.
Identification of High-Risk Host Cell Proteins for Biopharmaceutical Process Development with Advanced LC-MS-Based Proteomic Approaches
Host cell proteins (HCPs) are bioprocess impurities originating from the host cells used in biopharmaceutical manufacturing. Identifying and controlling high-risk HCPs is essential for maintaining product quality and shelf life. Notably, HCPs with hydrolase activity can degrade formulation excipient polysorbates, reducing drug stability. In this presentation, we will discuss advanced LC-MS-based proteomic approaches, including high-throughput proteomics and activity-based protein profiling (ABPP), to identify high-risk HCPs for biopharmaceutical process development.
Presenter: Shawn Li (Principal scientist, Merck)
Enhancing HCP-MS Analysis Capacity 3-10 Fold with EvoSep One
The introduction of a new USP chapter detailing the use of mass spectrometry for Host Cell Protein (HCP) analysis is set to significantly increase the demand for this type of analysis. In response to this anticipated growth, Alphalyse has investigated the application of the EvoSep One system. This system has been evaluated against the current technology used in over 600 projects, aiming to boost analysis capacity by 3 to 10 times.
Presenter: Thomas Kofoed, Ph.D. (Cofounder and CEO at Alphalyse)
