RT-MALS: Real-Time PAT for biologics, gene vectors and vaccines in downstream processing
While much effort has been invested in process analytics for upstream bioprocess, downstream operations still suffer from a lack of technologies suitable for inline/online monitoring of product attributes with rapid response times. Such a technology is real-time multi-angle light scattering (RT-MALS), which can be integrated inline with chromatographic purification or online with UF/DF and homogenization equipment.
RT-MALS determines biophysical attributes such as molecular weight and size of proteins, nucleic acids and polysaccharides, as well as size and particle concentration of lipid nanoparticles or viral vectors. Molecular weight and size discriminate product from impurities such as residual DNA or aggregates. For small vectors such as AAV, RT-MALS also determines empty and full titers and the full:total capsid ratio.
This webinar will cover the technology and implementation of RT-MALS in process development and process control, with case studies from the realm of monoclonal antibodies, proteins and viral vectors.
Key Learning Objectives:
- How RT-MALS accelerates bioprocess DSP development
- How RT-MALS controls downstream bioprocesses to enhance yield and lot consistency
- How RT-MALS integrates with continuous manufacturing of monoclonal antibodies
Who Should Attend:
- PAT experts for biologics, vaccines and gene therapies
- Biopharm process development scientists
- Downstream bioprocess engineers
- Biopharm MSAT leaders
