From Antibody Drug Conjugates to Lipid Nanoparticles: Complex Therapeutic Characterization using Light Scattering

Dynamic light scattering (DLS) and multi-angle light (MALS) are non-destructive techniques that provide multi-attribute quantification (MAQ) in a single analysis. They play a critical role in product and process development, as well as quality control.

In this virtual user meeting, we will cover case studies where light scattering is used in the characterization of complex therapeutics, such as antibody drug conjugates (ADCs), protein-conjugate vaccines (PCVs), and lipid nanoparticles (LNPs).

Registration is free for this event.

Key Takeaways:

• SEC-MALS provides native state characterization of binary conjugates
• Coupled to liquid chromatography, MALS can be used to calculate DAR, % aggregate, and % free mAb for ADCs
• Bulk characterization of ADCs using DLS can be critical for determining analyte stability
• DLS and MALS can be used for high throughput screening and high-resolution characterization of LNPs, respectively

Who should attend:

• Anyone interested in learning more about light scattering and its applications to complex/conjugated therapeutic characterization