Elevating Oligonucleotide Bioanalysis: LOQ, Dynamic Range, and Innovative Sample Preparation Techniques
In this presentation, we will explore groundbreaking advancements in the bioanalysis of antisense oligonucleotides (ASO), achieving remarkable sub ng/mL limits of quantitation (LOQ). We’ll dive into practical and scalable solutions that ensure precise quantitation of these complex molecules.
Discover innovative sample preparation techniques designed to maximize recovery, enhance repeatability, and boost LC-MS sensitivity. Additionally, we’ll showcase the latest LC-MS hardware from Waters, which not only delivers industry-leading negative ionization efficiency, but also saves valuable bench space and reduces utility usage compared to competitors.
Key Learning Objectives:
- Explore scalable solutions for quantifying complex oligonucleotides across a wide range of concentrations.
- Discover practical approaches that enhance recovery, repeatability, and LC‑MS sensitivity.
- Take advantage of the opportunity to attend the presentation live, where you'll have the chance to ask questions, engage, clarify, and deepen your understanding of the latest innovations in bioanalysis.
Presenter: Andrew Leightner (Senior Principal Market Development Manager, Pharmaceuticals and Biopharmaceuticals, Waters Corporation)
Andy Leightner has over 10 years of experience serving the pharma market from contract research organizations. He specialized in method development and validation leveraging LC, GC, and mass spectrometry to meet complex client needs. He supports pharmaceutical and biopharmaceutical discovery and development in the Americas for Waters Corporation. Andy received a bachelors degree in biology from the University of Wisconsin-Madison.
