Single-cell spatial metabolomics and lipidomics using AP-SMALDI and Orbitrap technology

Rebroadcast of the Live from the Lab: Solutions for Multi-Omics Research from June 13, 2024

Single-cell spatial metabolomics and lipidomics using AP-SMALDI and Orbitrap technology

In this session, Max A. Müller (TransMIT GmbH) discusses the importance of investigating single cells using mass spectrometry imaging. He explains how single cells come in various shapes and sizes, and how studying them at a bulk level may not provide accurate insights due to differences between cell phenotypes. Mass spectrometry imaging allows for high-resolution analysis, capturing the intricate details of single cells.

Max delves into the technical aspects of mass spectrometry imaging, including the use of a specialized objective lens and the importance of high lateral resolution and mass resolving power. He showcases several examples, such as investigating schistosomiasis and its impact on liver tissue, exploring the biochemical processes of apoptosis in intestinal organoids, and analyzing microglial cells in the central nervous system.

Don't miss this opportunity to learn from Max's expertise and gain insights into the cutting-edge field of mass spectrometry imaging.

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Presenter: Dr. Max A. Müller (TransMIT GmbH)