An approach to streamline and simplify the identification of crucial metabolites from targeted protein degraders
The identification of drug metabolites is a critical step in drug development due to their impact on drug efficacy and safety. LC-MS platforms provide good selectivity and sensitivity making it the preferred technique for metabolite identification.
Here, metabolite identification was performed using unique fragments from EAD and CID spectra. Fragment information from EAD and CID spectra were processed in a single result file to achieve confident structure assignment of and localization of metabolites.
Webinar Learning Objectives:
- Options to achieve more accurate structure assignments to gain a competitive edge in identifying drug metabolites
- How to enhance signal sensitivity for confident metabolite identification with Zeno trap technology
- Learn about a streamlined path from data acquisition to processing for metabolite identification using Molecule Profiler software
Presenter: Ebru Selin Selen (Biologics Applications Scientist, SCIEX)
Ebru Selen completed her doctoral degree at the University of Wisconsin-Madison before joining the Johns Hopkins School of Medicine for postdoctoral training. During the academic years, Ebru developed mass spectrometry and nuclear magnetic resonance spectroscopy methods to unravel the metabolic roles of well-known but underexplored liver-specific enzymes and pathways. The results of her projects and collaborative efforts have been published in high-impact journals such as the Journal of Proteome Research, Journal of Biological Chemistry, Cell Reports, and Cell Metabolism. Ebru Selen is currently a Biopharma Application Scientist at SCIEX. She specializes in applying new mass spectrometry technologies in pharma workflows for small and large molecules. She is collaborating with thought leaders in the pharma and biopharma community to provide solutions to analytical challenges.
