Hydrophobic Interaction Chromatography as a Platform for Characterizing ADCs

Christian Rohrer, Director Sales and Marketing at Tosoh Bioscience GmbH, will present the next edition of Tosoh Tuesday, a webinar series held by Chromatography Experts.

On Tuesday, April 16, Corey Meadows, Product Specialist Bioanalysis at Tosoh Bioscience, dives into the analysis of antibody-drug conjugates and their drug-antibody ratio by hydrophobic interaction chromatography.

Antibody-drug conjugates (ADCs) are dual-action cancer biotherapeutics, where monoclonal antibodies carrying tumor-killing payloads specifically bind to cancer cells and accelerate cancer cell death. Characterizing the ratio of tumor-killing payload to cancer-binding antibody (DAR) is a critical quality attribute needed to determine the potential potency of a given ADC candidate. This webinar features HIC as a solution for quantifying DARs in ADC biotherapeutics. An overview of ADC and HIC fundamentals will be presented, targeting analytical method development scientists seeking insights for mobile-phase and stationary-phase selections for separating variable conjugated ADC variants.

After the webinar, ask your questions during the live Q&A session.

Presenter: Christian Rohrer (Director Sales and Marketing at Tosoh Bioscience GmbH)

Presenter: Corey Meadows (Product Specialist Bioanalysis at Tosoh Bioscience)