Host Cell Protein (HCP) Profiling and Quantitation in Gene Therapy Products with the Orbitrap Astral Mass Spectrometer

Learn how you can achieve confident, sensitive and reproducible AAV HCP identification.

This webinar will demonstrate approaches to overcome key challenges with AAV HCP analysis, such as the highly complex proteome background and large dynamic range which necessitate the need for high sensitivity enabling the detection and quantification of low abundant HCPs, essential for safe and efficacious production of these advanced biotherapeutics.

In this webinar you’ll learn:

• How to overcome challenges in HCP analysis of AAV based gene therapies
• How to ensure you accurately profile and quantify critical HCP contaminants in the sub ppm range
• How the new Thermo Scientific Orbitrap Astral Mass Spectrometer can aid your HCP analysis

Presenter: (Jonathan Bones, Principal Investigator, Characterization and Comparability Group, NIBRT)

Professor Bones obtained his BS in Analytical Science (Chemistry) and PhD in Analytical Chemistry from Dublin City University (DCU). Jonathan joined Prof. Pauline M. Rudds group at NIBRT in 2007.