How HPLC-CAD Analysis Can Allow You to See Hidden Extractable Oligomers
Join us for an informative webinar where we'll unveil our innovative in-house method for studying Extractables and Leachables (E&L) substances in common medical and pharmaceutical-grade plastics.
We'll dive into the analysis of nylon, polyurethane, and PVC (epoxidized soybean oil) oligomers, showcasing our approach that leverages multiple advanced detectors to analyze a wide range of analytes with diverse chemical properties.
Our method incorporates an ingenious inverse gradient technique, fine-tuned with an in-line mixer and optimized gradient delay times. We'll demonstrate the application of a previously published calculation to determine analyte behavior, classifying them as non-volatiles or semi-volatiles using CAD (Charged Aerosol Detection).
By attending, you'll discover how our approach minimizes inter-analyte response factor variation, enhancing quantitative accuracy and reducing uncertainty in setting analytical evaluation thresholds. Ultimately, our method is designed to meet crucial requirements in E&L studies, ensuring efficient and cost-effective protection against potentially harmful substances. Don't miss this opportunity to stay at the forefront of E&L research.
Learning points:
determine which analytes behave as non-volatiles with CAD and can therefore be accurately quantified using surrogate standards
improve quantification accuracy and reduce response factor variation using an inverse gradient
use an in-line mixer to combine the analytical and inverse gradients and improve response uniformity
Who should attend:
Laboratory managers and directors
Technology leaders
Principal scientists
Laboratory analyst
Presenter: Katherine Lovejoy (Product Applications Specialist, Thermo Fisher Scientific)
Katherine Lovejoy, Ph.D. has been an application chemist focusing on charged aerosol detection at the Thermo Fisher Scientific HPLC factory site since 2016 and has a Ph.D. in inorganic chemistry from the Massachusetts Institute of Technology. She has experience as a chemist reviewer at the FDA and as a scientist at Los Alamos National Laboratory.
Presenter: Chris Tuczemskyi (Moderator, Product Marketing Manager, Thermo Fisher Scientific)
Chris Tuczemskyi is a chromatography specialist at Thermo Fisher Scientific, based in Cambridge, UK. After spending a number of years building up his experience with chromatography instruments in a water testing laboratory, he joined Thermo Fisher Scientific in 2014 as a chromatography service engineer for Unity Lab Services. Here he developed his passion for supporting customers using HPLC and in 2018 moved into the application specialist team. More recently, in 2022 he made the move to Product Marketing to help ensure we meet and exceed our customers expectation. In 2009, Chris graduated from the University of Essex in Biochemistry (Bsc Hons).
