Validation of Parameters for Karl Fischer Titration
Three Webinars and a Roundtable with Experts from Merck KGaA, Darmstadt, Germany, Metrohm & Mettler Toledo
A Week Dedicated to Karl Fischer Titration!
Karl Fischer titration is still the most used, most accurate, and fastest method to determine water content in all kinds of sample matrices. This titration week covers different aspects that need to be considered when determining the water content in products, raw materials, and other substances. Experts from the life science business of Merck KGaA, Darmstadt, Germany, Metrohm AG, and Mettler Toledo will present and discuss different steps of the Karl Fischer titration process and how to improve it. Learnings include:
- Karl Fischer titration process and tips for how to improve it
- Karl Fischer oven method and its advantages
- Reference materials to use for titer determination, instrument check, and result verification
- Parameters needed to validate a Karl Fischer titration application
- News and future aspects of Karl Fischer titration
Validation of Parameters for Karl Fischer Titration
Validation of parameters for a Karl Fischer titration method is an essential prerequisite for laboratories. Performance characteristics of the procedure need to meet the requirements for its intended purpose. You will learn typical analytical performance parameters that should be considered in the validation of the Karl Fischer titration procedures. The objective of this session is to present the requirements for a titration process.
By attending this presentation, you will learn about:
- General aspects of validation
- Required validation parameters
- How to verify the suitability and accuracy of a titration method
- An overview of the parameters described in ICH (International Council for Harmonization) guidance Q2(R1) and USP general chapter <1225> (selectivity, linearity, accuracy & reproducibility)
Presenter: Angela Schwehn (Laboratory Scientist in the R&D Department of the life science business of Merck KGaA, Darmstadt, Germany)
