Comprehensive and easy-to-use workflows for oligonucleotide sequence confirmation
Workflows for the analysis of oligonucleotides by high-resolution liquid chromatography-mass spectrometry (LC-MS) to support therapeutic drug development can often cover a wide range of modalities, ranging from heavily modified sequences to very large chains that exceed more than 50 nucleotide bases. The analytical need to support such complex and varied oligonucleotide sequences requires both high-quality LC-MS data, as well as comprehensive and easy-to-use data processing tools.
In this webinar, we will explore the data quality produced by the high-resolution LC-MS analysis of a range of oligonucleotides sequences, as well as the setup and processing of the subsequent results. Tools and workflows designed to automatically identify and confirm both full length product as well as product impurities will be discussed, including data processing and visual display capabilities intended to simplify sample analysis streamline data review.
Key learning objectives
- Discover new end-to-end LC-MS workflows for oligonucleotide analysis
- Learn how to identify and confirm full length oligonucleotides and product impurities
- Understand how easy-to-use software tools allow comprehensive analysis of a range of oligonucleotides
Who should attend?
- Biopharmaceutical research scientists
- Analytical scientists from biopharma companies working on, or interested in, oligonucleotide-based therapies
- PhD students in any field of biotherapeutic drug development
- Scientists looking to advance their knowledge of oligonucleotide analysis
Presenter: Keeley Murphy (Thermo Fisher Scientific, Inc.)
Keeley Murphy is a Software Product Manager with over 20 years’ experience working in the fields of pharmaceutical and analytical science. Over the past 10 years, he has worked within the BioPharma Marketing group at Thermo Fisher Scientific (MA, USA), providing global support for key customer collaborations and promoting the use of high-resolution mass spectrometry for quantitative bioanalysis. Recently transitioning to the role of Software Product Manager, he is currently responsible for the development of software solutions to support LC–MS quantitation and screening workflows.
Presenter: Georgina Wynne Hughes (Editorial Team)
Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
