Carboxen® Synthetic Carbon: A Derivatized Resin for Process and Preparative Chromatography

Activated carbons are widely used for purification and separation applications. However, they are not employable as chromatography media due to the lack of chemical purity, irregular shape, poor mechanical integrity, and lack of reproducibility.

Carboxen® synthetic carbon adsorbents are a synthetic form of activated carbon. These synthetic carbons are derivatized resins. Due to their high purity, spherical shape, and outstanding mechanical properties, Carboxen® synthetic carbon adsorbents are well suited for use in low-pressure liquid chromatography (LPLC) applications. This chromatography media can withstand pressures up to 110 MPa, which is several orders of magnitude greater than other LPLC media. The tapered pores improve the adsorbent’s kinetic and thermodynamic efficiency, enabling greater capacity while operating at increased throughputs. The highly engineered, derivatized resins bring value in both adsorption and hydrophobic interaction chromatography.

These media bring value to a wide range of LPLC applications for both small and large molecule separations. As example, these adsorbents are used for clearance of high-risk impurities in biochemical purifications such as host cell proteins, trace metals, and extractables and leachables. These synthetic carbons have been trusted by NASA on several missions including their use on the International Space Station.

By attending this presentation you will...

• learn about the features, advantages, and benefits of synthetic carbon separation media
• understand how a carbon media derived from resin offers a unique stationary phase
• discover several applications in both liquid and gas purifications where synthetic carbons bring value.

Presenter: Joe Abrahamson (Global Product Manager, Carbon Adsorbents and LPLC, MilliporeSigma)

Dr. Joe Abrahamson received his Ph.D. from Penn State, where he studied carbon materials and engineering. Before joining MilliporeSigma, Joe spent several years in the carbon and materials industries as an R&D scientist. Presently, Joe is the Global Product Manager for Carbon Adsorbents and LPLC at MilliporeSigma. Joe enjoys splitting his time between product management and product development.