Cyclic IMS in Action: The Powerful Combination with HDX

Join us to find out why the powerful combination of Hydrogen Deuterium Exchange (HDX) with the SELECT SERIES Cyclic IMS has sparked a lot of interest. See a demonstration of this technology in action, experience the latest software for data acquisition, visualization, and interpretation.

Explore how increased ion mobility and ToF resolution on the Cyclic IMS enable researchers to increase sequence coverage after deuterium incorporation and expand scientific knowledge.

Malcolm will also show some additional Cyclic IMS benefits, such as increased sensitivity allows access to sparsely available sample, high dynamic range detector enables a wider range of peptide intensities to be utilised , while maintaining the fidelity of isotope distributions and finally the higher quality raw data enables significant improvement in automatic data processing.

The session will conclude with a live Q&A where Malcolm Anderson and members of the Waters IMS-MS team will be on hand to answer all of your questions.  

Key Learning Objectives:

• Discover how we are pushing the boundaries of the SELECT SERIES Cyclic IMS in combination with HDX

• See the Cyclic IMS in action and the HDX analysis workflow 

• Explore how increased ion mobility and ToF resolution on the Cyclic IMS enable researchers to increase sequence coverage after deuterium incorporation and expand scientific knowledge.

Presenter: Malcolm Anderson (Principal Applications Chemist, Waters Corporation)

Malcolm joined Waters in 2012 after twenty one years in drug discovery research at AstraZeneca. His background there covered all aspects of recombinant protein science, from construct design, cloning and expression, through purification, detailed characterisation, and then their application to small molecule drug discovery using biophysical techniques. Since joining Waters, Malc has become experienced in many aspects of high resolution mass spectrometry as applied to proteins and peptides, initially in the field of proteomics but then transitioning to more biopharma-focused applications. As part of this, he has become one of Waters experts in hydrogen deuterium exchange (HDX) analysis.

Presenter: Owen Cornwell (Senior Applications Chemist, Waters Corporation)

Owen completed his PhD in structural mass spectrometry at the University of Leeds in 2019, specializing in the structural characterization of aggregation-prone proteins using MS methods. Following a postdoctoral position at AstraZeneca focusing on structural characterisaiton of biopharmaceuticals, Owen joined Waters in June 2021 as a senior applications chemist in the Demo lab in Wilmslow.