Ion Mobility Mass Spec - A 4th Dimension Gets More Information Faster Than Ever Before
Ion mobility is fast becoming mainstream. In this webinar, you will learn how Ion Mobility addresses current problems in the characterization of complex biomolecules. Ion Mobility adds another dimension of separation, allowing the detection of different molecular structural elements that would remain unseen by conventional mass spectrometry alone.
This webinar will demonstrate unique capabilities in separation and analysis using a low-field drift-tube based separation with Collision-induced unfolding (CIU), and the novel SLIM (Structures for Lossless Ion Manipulations) technology with highest full spectrum Ion Mobility resolution by incorporating a 13m non-linear ion path into a benchtop instrument. Focusing on Biopharma applications, this webinar will show how utilizing Ion Mobility can be used to obtain an in-depth understanding of the most challenging analyses.
Key Learning Objectives:
- Principles of Ion Mobility and the separation by shape
- Drift tube ion mobility
- Structures for Lossless Ion Manipulation (SLIM) technology and high-resolution ion mobility (HRIM)
- Collisional Cross Section (CCS) as an inherent chemical property to measure and exploit
- Collision induced unfolding (CIU) to understand protein stability and changes
- Fast separation and characterization of Glycans
- Ultra-high resolution Ion Mobility by miniaturized SLIM technology
- Separation of deamidated peptides using high-resolution Ion Mobility
- Validated workflows for MOBIE, highlighting real-world data
- Intact/subunit protein analysis
- Peptide analysis
- Released glycan analysis
- Targeted lipid analysis
- Benefit of adding a new separation dimension to MS workflows
- Reduced reliance on traditional chromatography
- High-throughput analysis of biologically relevant molecules in seconds
- High resolution separation of isobaric and isomeric species
Who Should Attend:
- Biopharma Analytical Scientists
- Lab Managers
- Principle Investigators
- Life Science Researchers
- Directors of biopharma research
- Discovery/R&D research scientists
- Early development/analytical development scientists
- Process development, process analytical support scientists
- Mass Spectrometry core lab directors, scientists, and technicians
- Professors, post-docs, and graduate students utilizing mass spectrometry
Presenter: Chris Klein (LC/Q-TOF Product Manager, Agilent Technologies)
Presenter: Tom Doherty (Senior Product Manager, MOBIE®, MOBILion Systems, Inc.)
Presenter: Kelly McSweeney (Contributing Editor, C&EN Media Group)
