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DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAY FOR OLIGONUCLEOTIDES

Postery | 2020 | WatersInstrumentace
Příprava vzorků, Spotřební materiál, LC/MS, LC/MS/MS, LC/QQQ
Zaměření
Klinická analýza
Výrobce
Waters
Klíčová slova
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Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
Application Note Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology Kathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. Rainville Waters Corporation Abstract The demand for highly selective and sensitive LC-MS bioanalytical assays in support of research and development…
Klíčová slova
oligonucleotide, oligonucleotidespe, speacquity, acquityxevo, xevomaxpeak, maxpeakyielded, yieldeduplc, uplctargetlynx, targetlynxbioanalytical, bioanalyticalpremier, premiertea, teaassays, assaysquantification, quantificationdemand, demandrecovery
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer Suma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MA Introduction Results Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes has been of…
Klíčová slova
oligonucleotide, oligonucleotideaccuracy, accuracyoligonucleotides, oligonucleotidesosts, ostsperformance, performanceantisense, antisensequantitation, quantitationlloq, lloqbioanalytical, bioanalyticalpolythymidine, polythymidinestd, stdpremier, premierconc, conconts, ontswaters
Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape
[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…
Klíčová slova
bioanalysis, bioanalysisimaging, imagingoligonucleotide, oligonucleotidetherapeutics, therapeuticsbioanalytical, bioanalyticalpeptide, peptidemolecules, moleculesprotein, proteintargeted, targetedtools, toolshighlights, highlightsread, readquantitative, quantitativequantification, quantificationsmall
Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides
Application Note Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides Suma Veeramachineni, Mark D. Wrona Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for…
Klíčová slova
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
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LabRulez s.r.o. Všechna práva vyhrazena. Obsah dostupný pod licencí CC BY-SA 4.0 Uveďte původ-Zachovejte licenci.