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Characterizing Weak Binding Events with Two Advanced Biophysical Techniques:  Hydrogen Deuterium Exchange (HDX-MS) and Differential Scanning Calorimetry (DSC)
1 PhD Dile Holton, Colette Quin, PhD.1 Characterizing Weak Binding Events with Two Advanced Biophysical Techniques: Hydrogen Deuterium Exchange (HDX-MS) and Differential Scanning Calorimetry (DSC) 1 2 Ahn Joomi 2 Asish Chakraborty 2 Ying Qing Yu, PhD – TA Instruments,…
Klíčová slova
hdx, hdxdsc, dscbinding, bindingweak, weakchanges, changesmutated, mutatedcalorimetry, calorimetrysites, sitesdeuterium, deuteriumstructure, structurevariant, variantasish, asishchakraborty, chakrabortyjoomi, joomiremovals
LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1  BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRY
LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1 BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRY Joomi Ahn 1, Xiaojun Lu2, Colette Quinn3, St John Skilton1, Ying Qing Yu1, and Jihong Wang2 1 Waters Corporation, 2 MedImmune, 3TA Instruments…
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mutated, mutatedpeptide, peptidedeuterium, deuteriumhdx, hdxconformational, conformationaluptake, uptakechanges, changesdeuteration, deuterationdynamx, dynamxplgs, plgscontrol, controlmhp, mhpsite, siteuptakes, uptakesdeuterated
Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry
Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…
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deuterium, deuteriumcalmodulin, calmodulinhdx, hdxconformational, conformationalapo, apoholo, holoexchange, exchangehydrogen, hydrogenprotein, proteinuptake, uptakepep, peppepsin, pepsinnanoacquity, nanoacquitycharacterization, characterizationspectrometry
Driving Native Mass Spectrometry of Membrane Proteins for Pharmaceutical Research
20 30 Conjugation Site (ADC) 40 32 0 340 20 350 0 10 10 0 350 20 340 CASE STUDY 0 3 Oxford Mass Technologies 20 0 50 33 0 31 3 40 0 0 0 0 31 30 60…
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omass, omassnative, nativeprotein, proteinproteins, proteinsbinding, bindingmass, massmembrane, membranetechnologies, technologiesuhmr, uhmrdrug, drugmational, mationalresearch, researchtechnology, technologybasic, basicpharmaceutical
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