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Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass Spectrometer

Postery | 2015 | Thermo Fisher ScientificInstrumentace
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Zaměření
Klinická analýza
Výrobce
Thermo Fisher Scientific
Klíčová slova
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Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping
APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…
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chain, chainheavy, heavypeptide, peptideadc, adcmass, massintact, intactnative, nativesetting, settingmapping, mappingconjugation, conjugationdrug, drugemtansine, emtansinelinker, linkerantibody, antibodylysine
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Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher…
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herceptin, herceptinchain, chainadc, adcnative, nativeantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrrelative, relativesigma, sigmacharacterization, characterizationmab, mabmonoclonal
Complete characterization of monoclonal antibodies under native and denaturing conditions
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intact, intacttrastuzumab, trastuzumabnative, nativehcd, hcdmass, massmab, mabsubunit, subunitthermo, thermodown, downdeconvolution, deconvolutionscientific, scientificsubunits, subunitspeptide, peptidemiddle, middleheavy
Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC) on a Hybrid Quadrupole-Orbitrap Mass Spectrometer
Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC) on a Hybrid Quadrupole-Orbitrap Mass Spectrometer Xiaoxi Zhang1, Kristina Srzentić2 and Min Du2, Thermo Fisher Scientific 1 Shanghai, China; 2 Cambridge, Massachusetts, US Purpose: In-depth characterization of an antibody cysteine-fluorophore conjugate standard…
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abundance, abundancerelative, relativelinker, linkerpeptide, peptideintact, intactdrug, drugftms, ftmsadc, adctvaptecs, tvaptecsconjugate, conjugatemapping, mappingdenatured, denaturedscdk, scdkantibody, antibodymin
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