MALDI Guided SpatialOMx uncovers proteomic profiles in tumor subpopulations of breast cancer
Aplikace | 2020 | BrukerInstrumentace
Iontová mobilita, MALDI, MS Imaging, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
ZaměřeníProteomika, Klinická analýza
VýrobceBruker
Klíčová slovatumor, subpopulations, timstof, maldi, imaging, subpopulation, segmentation, flex, pasef, lmd, breast, proteomics, spatialomx, proteomic, were, boundary, bruker, section, rois, coregistered, microextracted, segmenting, unsupervised, slides, image, naphthalate, regiospecific, tissue, areas, leica, clustering, dissected, annotated, teach, hematoxylin, depth, scils, sections, cancer, data, small, biological, stained, means, using, coordinates, process, developmental, parallel, pen
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Bruker timsTOF fleX - MALDI Guided SpatialOMx
2020|Bruker|Příručky
timsTOF MALDI Guided SpatialOMx Innovation with Integrity TIMS-MALDI MS MALDI Guided SpatialOMx The tumor microenvironment is a highly variable ecosystem, giving it an intrinsic temporal character. De-coding the cellular communication within the tumor microenvironment via label-free MALDI Imaging and x-omics…
Klíčová slova
maldi, malditimstof, timstofspatialomx, spatialomxflex, fleximaging, imagingbruker, brukerlaunches, launchesscils, scilstumor, tumorpasef, pasefmicroenvironment, microenvironmenttissue, tissueomics, omicslab, labtims
CCS-aware SpatialOMx® enables highly confident and automatic lipid annotations with regiospecific context
2021|Bruker|Aplikace
Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…
Klíčová slova
ccs, ccsmaldi, maldispatialomx, spatialomximaging, imagingaware, awareannotation, annotationtims, timsmobility, mobilityannotated, annotatedannotations, annotationspasef, pasefbucket, bucketlipid, lipidsegmentation, segmentationlipids
Novel MALDI Imaging solution empowered by a timsTOF fleX and dedicated bioinformatics pipeline for identification of lipids from tissue
2019|Bruker|Aplikace
Novel MALDI Imaging solution empowered by a timsTOF fleX and dedicated bioinformatics pipeline for identification of lipids from tissue MALDI Imaging spectra can be used to investigate how compounds are localized across tissue samples. In this application note, we present…
Klíčová slova
scils, scilsimaging, imagingmaldi, malditimstof, timstofflex, flexmetaboscape, metaboscapetissue, tissueannotations, annotationslab, labannotation, annotationbruker, brukerdata, dataroi, roiannotated, annotatedmolecules
Tumor heterogeneity of glioblastoma analyzed via SpatialOMx and HiPLEX-IHC MALDI Imaging
2023|Bruker|Postery
ASMS 2023 Tumor heterogeneity of glioblastoma analyzed via SpatialOMx and HiPLEX-IHC MALDI Imaging Corinna Henkel1, Signe Frost Frederiksen1, Matthias Szesny1, Jörg Bartsch2, Katherine Stumpo3, Melanie Föll4, Oliver Schilling4 1Bruker Daltonics GmbH & Co.KG, 28359 Bremen, Germany 2Department of Neurosurgery/Lab, Faculty…
Klíčová slova
hiplex, hiplexihc, ihcmaldi, malditumor, tumorimaging, imagingglioblastoma, glioblastomaheterogeneity, heterogeneityspatialomx, spatialomxmicroenvironment, microenvironmentlipid, lipidastrocytoma, astrocytomagbm, gbmspecific, specifictissue, tissuecells
