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Kinase inhibition screening by label-free mass spectrometry employing the MALDI PharmaPulse HTS solution

 

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Label-free compound profiling in K562 leukemia cells by MALDI-TOF mass spectrometry using heme B as response marker Bruker’s very fast rapifleX MALDI PharmaPulse solution has been successfully used in pharmaceutical research for compound screening in various cell-free biochemical assays that…
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maldi, maldirapiflex, rapiflexabl, ablbcr, bcrinhibitors, inhibitorslaser, laserheme, hemecells, cellsmarker, markertof, tofresponse, responseimatinib, imatinibpharmacodynamic, pharmacodynamicintensity, intensitychloroquine
Label-free drug uptake analysis of whole cells by MALDI-TOF mass spectrometry using the transport protein OATP2B1 as an example In this application note, we demonstrate a MALDI MS cellular drug uptake and inhibition assay [1]. It was conducted in HEK293…
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maldi, maldirapiflex, rapiflexreadouts, readoutsuptake, uptakeradiolabelled, radiolabelledcybio, cybiodrug, drugdroplet, droplettransport, transportcells, cellsinhibition, inhibitionscreening, screeningcell, cellinhibitors, inhibitorsassay
Profiling mammalian cell differentiation by MALDI-TOF MS: Developing a highly reproducible and robust sample preparation workflow In this application note, we present a universal workflow for mammalian cell MALDI-TOF MS analysis in order to distinguish between ground-state naïve and differentiating…
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maldi, malditof, tofrapiflex, rapiflexfreeze, freezelaser, laserpharmapulse, pharmapulsenaïve, naïvethaw, thawhts, htsassays, assayscell, cellcells, cellscellular, cellularthawing, thawingdhb
Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate Novel Synthesis Screening workflow in MALDI PharmaPulse software that was developed for screening of synthetic chemical reactions is applied to screen a custom library…
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maldi, maldisynthesis, synthesisscreening, screeningplate, platepharmapulse, pharmapulsetof, toffailed, failedultrahigh, ultrahighposition, positionruns, runsmolecule, moleculelibrary, libraryphotoredox, photoredoxnovel, novelmodule
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